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- W2954544650 endingPage "194398" @default.
- W2954544650 startingPage "194398" @default.
- W2954544650 abstract "The conformation and mechanism of proteins that degrade and bind RNA, which has provided key insights into post-transcriptional gene regulation, is explored here. During the twentieth century's last decades, the characterization of ribonucleases and RNA binding domains revealed the diversity of their reaction mechanisms and modes of RNA recognition, and the bases of protein folding, substrate specificity and binding affinity. More recent research showed how these domains combine through oligomerization or genetic recombination to create larger proteins with highly specific and readily programmable ribonucleolytic activity. In the last 15 years, the study of the capacity of proteins, usually disordered, to pool RNAs into discrete, non-aqueous microdroplets to facilitate their transport, modification and degradation - analogous to cowboys herding cattle - has advanced our comprehension of gene expression. Finally, the current uses of RNA binding proteins and the future applications of protein/RNA microdroplets are highlighted." @default.
- W2954544650 created "2019-07-12" @default.
- W2954544650 creator A5006206320 @default.
- W2954544650 creator A5057284948 @default.
- W2954544650 date "2019-11-01" @default.
- W2954544650 modified "2023-09-25" @default.
- W2954544650 title "RNA binding proteins: Diversity from microsurgeons to cowboys" @default.
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