Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954564208> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2954564208 abstract "Author(s): Liu, Eulanca Yuka | Advisor(s): Buxton, Richard B. | Abstract: The development of functional magnetic resonance imaging (fMRI) caused a paradigm shift in the study of neuroscience. However, despite the boom in research, fMRI has had a much smaller impact in the clinical setting. This is due to the complexity of the blood- oxygenation level dependent (BOLD) signal and its lack of inherent physiological meaning. Instead, cerebral blood flow (CBF) and cerebral metabolism of oxygen (CMRO2) have been proposed as physiological indicators of neural activity, and noninvasive measurement of these parameters could lead to improved applicability to clinical problems. While arterial spin labeling (ASL) techniques are well-established for measuring baseline CBF and fractional changes in CBF to a stimulus, measurements of CMRO2 are more controversial. Some methods to estimate CMRO2 involve contrast injection or administration of special gases, which could potentially prevent their use in certain patient populations.Here, the feasibility for quantitative measurements reflective of neural physiology is established. This is accomplished through a suite of tools to estimate specific physiological metrics that reflect baseline CBF and CMRO2 and their responses to a standard stimulus, without encumbering the patient. The techniques utilized are Velocity Selective Excitation and Arterial Nulling (VSEAN) to measure oxygen extraction fraction (OEF), which leads to the calculation of baseline CMRO2, and FLuid Attenuated Inversion Recovery-Gradient Echo Sampling of Spin Echo (FLAIR-GESSE) to calibrate baseline deoxyhemoglobin through R2', leading to fractional CMRO2 estimates. These, in combination with the latest BOLD/ASL acquisitions, form a toolbox that allows for full physiological quantification. Initial results demonstrate values of baseline CMRO2 that match previously reported results, as well as a close relationship between R2' data and widely-used gas method results. The toolbox is then applied to detecting changes in brain state induced by caffeine administration. Measurements in the pre- and post-caffeine states illustrate the ability of the toolbox to 1) reproduce known physiological changes due to caffeine and 2) significantly distinguish the change in brain state due to this intervention. These results demonstrate the use of physiological fMRI in providing a more detailed and reproducible picture of the human brain at work, paving the way for future clinical applications." @default.
- W2954564208 created "2019-07-12" @default.
- W2954564208 creator A5071544469 @default.
- W2954564208 date "2019-01-01" @default.
- W2954564208 modified "2023-09-24" @default.
- W2954564208 title "Establishing a foundation for physiological fMRI: How do we noninvasively quantify the human brain at work?" @default.
- W2954564208 hasPublicationYear "2019" @default.
- W2954564208 type Work @default.
- W2954564208 sameAs 2954564208 @default.
- W2954564208 citedByCount "0" @default.
- W2954564208 crossrefType "journal-article" @default.
- W2954564208 hasAuthorship W2954564208A5071544469 @default.
- W2954564208 hasConcept C101070640 @default.
- W2954564208 hasConcept C126838900 @default.
- W2954564208 hasConcept C143409427 @default.
- W2954564208 hasConcept C154945302 @default.
- W2954564208 hasConcept C15744967 @default.
- W2954564208 hasConcept C157767197 @default.
- W2954564208 hasConcept C164705383 @default.
- W2954564208 hasConcept C169760540 @default.
- W2954564208 hasConcept C180747234 @default.
- W2954564208 hasConcept C2779226451 @default.
- W2954564208 hasConcept C2779918689 @default.
- W2954564208 hasConcept C2780238834 @default.
- W2954564208 hasConcept C3017539923 @default.
- W2954564208 hasConcept C3018723549 @default.
- W2954564208 hasConcept C41008148 @default.
- W2954564208 hasConcept C58693492 @default.
- W2954564208 hasConcept C71924100 @default.
- W2954564208 hasConceptScore W2954564208C101070640 @default.
- W2954564208 hasConceptScore W2954564208C126838900 @default.
- W2954564208 hasConceptScore W2954564208C143409427 @default.
- W2954564208 hasConceptScore W2954564208C154945302 @default.
- W2954564208 hasConceptScore W2954564208C15744967 @default.
- W2954564208 hasConceptScore W2954564208C157767197 @default.
- W2954564208 hasConceptScore W2954564208C164705383 @default.
- W2954564208 hasConceptScore W2954564208C169760540 @default.
- W2954564208 hasConceptScore W2954564208C180747234 @default.
- W2954564208 hasConceptScore W2954564208C2779226451 @default.
- W2954564208 hasConceptScore W2954564208C2779918689 @default.
- W2954564208 hasConceptScore W2954564208C2780238834 @default.
- W2954564208 hasConceptScore W2954564208C3017539923 @default.
- W2954564208 hasConceptScore W2954564208C3018723549 @default.
- W2954564208 hasConceptScore W2954564208C41008148 @default.
- W2954564208 hasConceptScore W2954564208C58693492 @default.
- W2954564208 hasConceptScore W2954564208C71924100 @default.
- W2954564208 hasLocation W29545642081 @default.
- W2954564208 hasOpenAccess W2954564208 @default.
- W2954564208 hasPrimaryLocation W29545642081 @default.
- W2954564208 hasRelatedWork W1192732516 @default.
- W2954564208 hasRelatedWork W2010587277 @default.
- W2954564208 hasRelatedWork W2010736182 @default.
- W2954564208 hasRelatedWork W20224263 @default.
- W2954564208 hasRelatedWork W2024213667 @default.
- W2954564208 hasRelatedWork W2035535254 @default.
- W2954564208 hasRelatedWork W2048558734 @default.
- W2954564208 hasRelatedWork W2058352845 @default.
- W2954564208 hasRelatedWork W2102673550 @default.
- W2954564208 hasRelatedWork W2132295790 @default.
- W2954564208 hasRelatedWork W2133518341 @default.
- W2954564208 hasRelatedWork W2739367073 @default.
- W2954564208 hasRelatedWork W2778566973 @default.
- W2954564208 hasRelatedWork W2790620361 @default.
- W2954564208 hasRelatedWork W2795224682 @default.
- W2954564208 hasRelatedWork W2802909215 @default.
- W2954564208 hasRelatedWork W2921079209 @default.
- W2954564208 hasRelatedWork W2187346682 @default.
- W2954564208 hasRelatedWork W2189404344 @default.
- W2954564208 hasRelatedWork W2339396632 @default.
- W2954564208 isParatext "false" @default.
- W2954564208 isRetracted "false" @default.
- W2954564208 magId "2954564208" @default.
- W2954564208 workType "article" @default.