FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954588828> ?p ?o ?g. }

• W2954588828 abstract "Carcinogenesis is closely associated with abnormal regulation of gene expression, among which DNA methylation in one of the key epigenetic modifications. Therefore, several studies have been directed towards the evaluation of DNA methylation. Here, we aimed to experimentally observe the specific signal of methylated DNA in various blood cancer cell lines using terahertz (THz) radiation, which is presented as a resonance in the spectrum. THz radiations are electromagnetic waves having frequencies of 0.1−10 THz, which falls between those of infrared radiation and microwaves. Molecular low-energy motions in THz region, such as collective vibrations, torsion of molecular structures, and hydrogen bonds, is correlated with biological characteristics, i.e., vibrational modes of DNA, structural modes in proteins, cell membrane vibrations, or enzyme activity. These features are usually presented as a characteristic resonance of the modes in the THz spectrum. In our study, the degree of global DNA methylation was obtained by the quantification of the resonance around 1.7 THz, and the results were in good agreement with those obtained by enzyme-linked immunosorbent assay (ELISA). Further, DNA demethylation was performed using high-power THz radiation around the resonance frequency of 1.7 THz, which lead to a 10% to 72% decrease in the degree of DNA methylation as shown in Table 1. Thus, our data shows the feasibility of using THz radiation for the assessment and manipulation of DNA methylation. This is the first study wherein the sensing and manipulation of DNA methylation could be achieved using a non-contact and non-invasive optical technique. Use of THz radiation for the assessment of DNA methylation might be helpful for its rapid processing, while THz manipulation of DNA methylation can avoid the toxicity of chemical demethylating agents. We propose that THz radiation may be useful for the diagnosis of cancer and we expect that THz demethylation might find potential application in cancer therapy. Citation Format: Hee-Jin Yang, Hwayeong Cheon, Jin Ho Paik, Joo-Hiuk Son. Assessment and manipulation of DNA methylation in cancer cells using terahertz radiation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 817." @default.
• W2954588828 created "2019-07-12" @default.
• W2954588828 creator A5018875264 @default.
• W2954588828 creator A5022713561 @default.
• W2954588828 creator A5055005940 @default.
• W2954588828 creator A5057537444 @default.
• W2954588828 date "2019-07-01" @default.
• W2954588828 modified "2023-10-04" @default.
• W2954588828 title "Abstract 817: Assessment and manipulation of DNA methylation in cancer cells using terahertz radiation" @default.
• W2954588828 doi "https://doi.org/10.1158/1538-7445.sabcs18-817" @default.
• W2954588828 hasPublicationYear "2019" @default.
• W2954588828 type Work @default.
• W2954588828 sameAs 2954588828 @default.
• W2954588828 citedByCount "0" @default.
• W2954588828 crossrefType "proceedings-article" @default.
• W2954588828 hasAuthorship W2954588828A5018875264 @default.
• W2954588828 hasAuthorship W2954588828A5022713561 @default.
• W2954588828 hasAuthorship W2954588828A5055005940 @default.
• W2954588828 hasAuthorship W2954588828A5057537444 @default.
• W2954588828 hasConcept C104317684 @default.
• W2954588828 hasConcept C107816215 @default.
• W2954588828 hasConcept C121332964 @default.
• W2954588828 hasConcept C139210041 @default.
• W2954588828 hasConcept C150194340 @default.
• W2954588828 hasConcept C153911025 @default.
• W2954588828 hasConcept C184779094 @default.
• W2954588828 hasConcept C185592680 @default.
• W2954588828 hasConcept C190727270 @default.
• W2954588828 hasConcept C33288867 @default.
• W2954588828 hasConcept C41091548 @default.
• W2954588828 hasConcept C46141821 @default.
• W2954588828 hasConcept C49040817 @default.
• W2954588828 hasConcept C552990157 @default.
• W2954588828 hasConcept C55493867 @default.
• W2954588828 hasConcept C555283112 @default.
• W2954588828 hasConcept C86803240 @default.
• W2954588828 hasConceptScore W2954588828C104317684 @default.
• W2954588828 hasConceptScore W2954588828C107816215 @default.
• W2954588828 hasConceptScore W2954588828C121332964 @default.
• W2954588828 hasConceptScore W2954588828C139210041 @default.
• W2954588828 hasConceptScore W2954588828C150194340 @default.
• W2954588828 hasConceptScore W2954588828C153911025 @default.
• W2954588828 hasConceptScore W2954588828C184779094 @default.
• W2954588828 hasConceptScore W2954588828C185592680 @default.
• W2954588828 hasConceptScore W2954588828C190727270 @default.
• W2954588828 hasConceptScore W2954588828C33288867 @default.
• W2954588828 hasConceptScore W2954588828C41091548 @default.
• W2954588828 hasConceptScore W2954588828C46141821 @default.
• W2954588828 hasConceptScore W2954588828C49040817 @default.
• W2954588828 hasConceptScore W2954588828C552990157 @default.
• W2954588828 hasConceptScore W2954588828C55493867 @default.
• W2954588828 hasConceptScore W2954588828C555283112 @default.
• W2954588828 hasConceptScore W2954588828C86803240 @default.
• W2954588828 hasLocation W29545888281 @default.
• W2954588828 hasOpenAccess W2954588828 @default.
• W2954588828 hasPrimaryLocation W29545888281 @default.
• W2954588828 hasRelatedWork W2006384537 @default.
• W2954588828 hasRelatedWork W2017286831 @default.
• W2954588828 hasRelatedWork W2017681315 @default.
• W2954588828 hasRelatedWork W2026674035 @default.
• W2954588828 hasRelatedWork W2031269788 @default.
• W2954588828 hasRelatedWork W2097596363 @default.
• W2954588828 hasRelatedWork W2105784501 @default.
• W2954588828 hasRelatedWork W2157889483 @default.
• W2954588828 hasRelatedWork W2332547497 @default.
• W2954588828 hasRelatedWork W2537518441 @default.
• W2954588828 hasRelatedWork W2763341003 @default.
• W2954588828 hasRelatedWork W2941410036 @default.
• W2954588828 hasRelatedWork W2944231208 @default.
• W2954588828 hasRelatedWork W2981148546 @default.
• W2954588828 hasRelatedWork W2991334953 @default.
• W2954588828 hasRelatedWork W3025368697 @default.
• W2954588828 hasRelatedWork W3197656217 @default.
• W2954588828 hasRelatedWork W3204937878 @default.
• W2954588828 hasRelatedWork W2403922271 @default.
• W2954588828 hasRelatedWork W2859474665 @default.
• W2954588828 isParatext "false" @default.
• W2954588828 isRetracted "false" @default.
• W2954588828 magId "2954588828" @default.
• W2954588828 workType "article" @default.