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- W2954610613 abstract "Multiple studies have indicated that physical activity regulation may be largely controlled by central neural factors, such as dopamine (DA) signaling in the nucleus accumbens (NAc). DA signaling has been shown to be altered by nutritional interventions. The key identified proteins involved with DA signaling are DA receptors one and two (DRD1, DRD2), tyrosine hydroxylase (TH), vesicular monoamine transporter (VMAT), and DA transporter (DAT). PURPOSE: To determine if a high fat/high sugar (HFHS) diet alters DA signaling in the NAc of male and female C57Bl/6J mice. METHODS: Mice were randomly assigned to either a HFHS diet or a standard CHOW diet (C) at three weeks of age for a total of nine weeks. The C diet consisted of 4% fat, 25.2% protein, 39.5% carbohydrate, and 23.2% fiber, while the HFHS diet consisted of 45% fat, 20% protein, and 35% carbohydrate along with a 20% fructose solution replacing drinking water. Physical activity was measured using a running wheel for three days during the last week. Mice were sacrificed at 12 weeks, the NAc was dissected on ice, and flash frozen in liquid nitrogen. Immunoblotting was performed using NAc lysate probed with the following antibodies; DRD1, DRD2, TH, VMAT, DAT. Bands were analyzed after normalization using Welch’s t-tests to compare target protein densitometries between the HFHS and C diet conditions. RESULTS: There were no significant differences in protein densitometries in male mice for DRD1, TH, VMAT, DAT, or DRD2 (p= 0.85; 0.46; 0.38; 0.38; 0.36 respectively) or in female mice (p= 0.16; 0.39; 0.31; 0.33; 0.83 respectively). CONCLUSION: A HFHS diet did not alter dopaminergic receptor or transporter densities in the NAc. Previous analyses revealed the HFHS group had greater kcal consumption and decreased physical activity while the C diet group had lower kcal consumption and higher physical activity. Thus, we conclude that each group mediated DA activity via separate mechanisms; the HFHS through diet and the C through physical activity." @default.
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- W2954610613 date "2019-06-01" @default.
- W2954610613 modified "2023-09-27" @default.
- W2954610613 title "Dopaminergic Receptor and Transporter Densities in Nucleus Accumbens Are Not Altered by a Western Diet" @default.
- W2954610613 doi "https://doi.org/10.1249/01.mss.0000560813.47742.9b" @default.
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