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• W2954650393 abstract "Purpose To extend the variably‐accelerated sensitivity encoding (vSENSE) method from 2D to 3D for fast chemical exchange saturation transfer (CEST) imaging, and prospectively implement it for clinical MRI. Methods The CEST scans were acquired from 7 normal volunteers and 15 brain tumor patients using a 3T clinical scanner. The 2D and 3D “artifact suppression” (AS) vSENSE algorithms were applied to generate sensitivity maps from a first scan acquired with conventional SENSE‐accelerated 2D and 3D CEST data. The AS sensitivity maps were then applied to reconstruct the other CEST frames at higher acceleration factors. Both retrospective and prospective acceleration in phase‐encoding and slice‐encoding dimensions were implemented. Results Applying the 2D AS vSENSE algorithm to a 2‐fold undersampled 3.5‐ppm CEST frame halved the scan time of conventional SENSE, while generating essentially identical reconstruction errors ( p ≈ 1.0). The 3D AS vSENSE algorithm permitted prospective acceleration by up to 8‐fold, in total, from phase‐encoding and slice‐encoding directions for individual source CEST images, and an overall speed‐up in scan time of 5‐fold. The resulting vSENSE‐accelerated amide proton transfer–weighted images agreed with conventional 2‐fold‐accelerated SENSE CEST results in brain tumor patients and healthy volunteers. Importantly, the vSENSE method eliminated unfolding artifacts in the slice‐encoding direction that compromised conventional SENSE CEST scans. Conclusion The vSENSE method can be extended to 3D CEST imaging to provide higher acceleration factors than conventional SENSE without compromising accuracy." @default.
• W2954650393 created "2019-07-12" @default.
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• W2954650393 date "2019-07-01" @default.
• W2954650393 modified "2023-10-14" @default.
• W2954650393 title "Fast 3D chemical exchange saturation transfer imaging with variably‐accelerated sensitivity encoding (vSENSE)" @default.
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• W2954650393 doi "https://doi.org/10.1002/mrm.27881" @default.
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