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• W2954653284 endingPage "84" @default.
• W2954653284 startingPage "74" @default.
• W2954653284 abstract "Seizure activity stimulates adult neurogenesis, the birth of new neurons, in the hippocampus. Many new neurons that develop in the presence of repeatedly induced seizures acquire abnormal morphological and functional characteristics that can promote network hyperexcitability and hippocampal dysfunction. However, the impact of seizure induced neurogenesis on behaviour remains poorly understood. In this study, we investigated whether adult-born neurons generated immediately before and during chronic seizures were capable of integration into behaviorally relevant hippocampal networks. Adult rats underwent pentylenetetrazole (PTZ) kindling for either 1 or 2 weeks. Proliferating cells were labelled with BrdU immediately before kindling commenced. Twenty-four hours after receiving their last kindling treatment, rats were placed in a novel environment and allowed to freely explore for 30 min. The rats were euthanized 90 min later to examine for behaviourally-induced immediate early gene expression (c-fos, Zif268). Using this approach, we found that PTZ kindled rats did not differ from control rats in regards to exploratory behaviour, but there was a marked attenuation in behaviour-induced expression of Fos and Zif268 for rats that received 2 weeks of PTZ kindling. Further examination revealed that PTZ kindled rats showed reduced colocalization of Fos and Zif268 in 2.5 week old BrdU + cells. The proportion of immature granule cells (doublecortin-positive) expressing behaviorally induced Zif268 was also significantly lower for PTZ kindled rats than control rats. These results suggest that chronic seizures can potentially disrupt the ability of adult-born cells to functionally integrate into hippocampal circuits important for the processing of spatial information." @default.
• W2954653284 created "2019-07-12" @default.
• W2954653284 creator A5004473163 @default.
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• W2954653284 creator A5064850937 @default.
• W2954653284 creator A5071614994 @default.
• W2954653284 creator A5082657039 @default.
• W2954653284 date "2019-10-01" @default.
• W2954653284 modified "2023-10-04" @default.
• W2954653284 title "Spatial exploration induced expression of immediate early genes Fos and Zif268 in adult-born neurons Is reduced after pentylenetetrazole kindling" @default.
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• W2954653284 doi "https://doi.org/10.1016/j.brainresbull.2019.07.003" @default.
• W2954653284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31279580" @default.

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