FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954693755> ?p ?o ?g. }

• W2954693755 endingPage "360" @default.
• W2954693755 startingPage "355" @default.
• W2954693755 abstract "To evaluate the impact of galsulfase enzyme replacement therapy (ERT) when initiated in adulthood for patients with mucopolysaccharidosis (MPS) VI.In 2005, the multi-national, MPS VI Clinical Surveillance Program (CSP) was established to collect long-term observational data from routine clinical and laboratory assessments. A sub-analysis was performed in patients who started ERT at ≥16 years of age and had received galsulfase for ≥6 months. Urinary glycosaminoglycans (uGAG), 6-min walk test (6MWT), 3-min stair climb test (3MSCT), pulmonary function measures, cardiac function, ophthalmology measures, liver and spleen sizes, and safety were evaluated.Of 223 patients enrolled in the CSP, 51 were included in the sub-analysis. Patients were between 16 and 63 years of age at first infusion. From pre-treatment baseline, uGAG level decreased by a mean (±standard deviation [SD]) of 66 (±45)% (N = 29) after a median follow-up of 7.2 years. 6MWT distance decreased slightly by a mean of 17 (±107) meters (N = 23) after 6.6 years. Stairs/min in the 3MSCT increased by a mean of 26 (±33) (N = 14) after 2.8 years. Pulmonary function measures, forced expiratory volume in 1 second and forced vital capacity, increased by a mean of 0.06 (±0.21) L after 7.3 years and 0.05 (±0.28) L after 7.2 years, respectively (N = 19 for both measures). Overall, galsulfase was well tolerated, with most adverse events reported being MPS-related clinical manifestations and not related to galsulfase.Results of this sub-analysis of the CSP suggest that initiation of galsulfase in adulthood is well tolerated and can possibly stabilize MPS VI in the long term." @default.
• W2954693755 created "2019-07-12" @default.
• W2954693755 creator A5000891412 @default.
• W2954693755 creator A5002597500 @default.
• W2954693755 creator A5036671369 @default.
• W2954693755 creator A5045038683 @default.
• W2954693755 creator A5055779533 @default.
• W2954693755 creator A5058509591 @default.
• W2954693755 creator A5061521388 @default.
• W2954693755 creator A5081155368 @default.
• W2954693755 date "2019-08-01" @default.
• W2954693755 modified "2023-09-25" @default.
• W2954693755 title "Enzyme replacement therapy initiated in adulthood: Findings from the mucopolysaccharidosis VI Clinical Surveillance Program" @default.
• W2954693755 cites W1980579070 @default.
• W2954693755 cites W2004988832 @default.
• W2954693755 cites W2015783210 @default.
• W2954693755 cites W2022821755 @default.
• W2954693755 cites W2025554084 @default.
• W2954693755 cites W2041158844 @default.
• W2954693755 cites W2067911935 @default.
• W2954693755 cites W2068499319 @default.
• W2954693755 cites W2085987206 @default.
• W2954693755 cites W2094882071 @default.
• W2954693755 cites W2103037586 @default.
• W2954693755 cites W2136069293 @default.
• W2954693755 cites W2159320756 @default.
• W2954693755 cites W2164020569 @default.
• W2954693755 cites W2167018562 @default.
• W2954693755 cites W2171316646 @default.
• W2954693755 cites W2415339601 @default.
• W2954693755 cites W2532643135 @default.
• W2954693755 cites W2587637263 @default.
• W2954693755 cites W4211029489 @default.
• W2954693755 doi "https://doi.org/10.1016/j.ymgme.2019.06.008" @default.
• W2954693755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31324526" @default.
• W2954693755 hasPublicationYear "2019" @default.
• W2954693755 type Work @default.
• W2954693755 sameAs 2954693755 @default.
• W2954693755 citedByCount "7" @default.
• W2954693755 countsByYear W29546937552019 @default.
• W2954693755 countsByYear W29546937552020 @default.
• W2954693755 countsByYear W29546937552021 @default.
• W2954693755 countsByYear W29546937552022 @default.
• W2954693755 countsByYear W29546937552023 @default.
• W2954693755 crossrefType "journal-article" @default.
• W2954693755 hasAuthorship W2954693755A5000891412 @default.
• W2954693755 hasAuthorship W2954693755A5002597500 @default.
• W2954693755 hasAuthorship W2954693755A5036671369 @default.
• W2954693755 hasAuthorship W2954693755A5045038683 @default.
• W2954693755 hasAuthorship W2954693755A5055779533 @default.
• W2954693755 hasAuthorship W2954693755A5058509591 @default.
• W2954693755 hasAuthorship W2954693755A5061521388 @default.
• W2954693755 hasAuthorship W2954693755A5081155368 @default.
• W2954693755 hasBestOaLocation W29546937551 @default.
• W2954693755 hasConcept C126322002 @default.
• W2954693755 hasConcept C165637977 @default.
• W2954693755 hasConcept C187212893 @default.
• W2954693755 hasConcept C197934379 @default.
• W2954693755 hasConcept C2777714996 @default.
• W2954693755 hasConcept C2779134260 @default.
• W2954693755 hasConcept C2779416428 @default.
• W2954693755 hasConcept C2779969927 @default.
• W2954693755 hasConcept C3018587741 @default.
• W2954693755 hasConcept C55520419 @default.
• W2954693755 hasConcept C71924100 @default.
• W2954693755 hasConcept C75603125 @default.
• W2954693755 hasConceptScore W2954693755C126322002 @default.
• W2954693755 hasConceptScore W2954693755C165637977 @default.
• W2954693755 hasConceptScore W2954693755C187212893 @default.
• W2954693755 hasConceptScore W2954693755C197934379 @default.
• W2954693755 hasConceptScore W2954693755C2777714996 @default.
• W2954693755 hasConceptScore W2954693755C2779134260 @default.
• W2954693755 hasConceptScore W2954693755C2779416428 @default.
• W2954693755 hasConceptScore W2954693755C2779969927 @default.
• W2954693755 hasConceptScore W2954693755C3018587741 @default.
• W2954693755 hasConceptScore W2954693755C55520419 @default.
• W2954693755 hasConceptScore W2954693755C71924100 @default.
• W2954693755 hasConceptScore W2954693755C75603125 @default.
• W2954693755 hasFunder F4320310557 @default.
• W2954693755 hasIssue "4" @default.
• W2954693755 hasLocation W29546937551 @default.
• W2954693755 hasLocation W29546937552 @default.
• W2954693755 hasOpenAccess W2954693755 @default.
• W2954693755 hasPrimaryLocation W29546937551 @default.
• W2954693755 hasRelatedWork W1584581471 @default.
• W2954693755 hasRelatedWork W1978534311 @default.
• W2954693755 hasRelatedWork W2068499319 @default.
• W2954693755 hasRelatedWork W2116587201 @default.
• W2954693755 hasRelatedWork W2129772791 @default.
• W2954693755 hasRelatedWork W2171316646 @default.
• W2954693755 hasRelatedWork W2993504738 @default.
• W2954693755 hasRelatedWork W3001295157 @default.
• W2954693755 hasRelatedWork W3044107529 @default.
• W2954693755 hasRelatedWork W3082276934 @default.
• W2954693755 hasVolume "127" @default.
• W2954693755 isParatext "false" @default.
• W2954693755 isRetracted "false" @default.
• W2954693755 magId "2954693755" @default.

• next