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• W2954694503 abstract "People living with HIV (PLWH) often present with lower heart rate variability (HRV) than healthy counterparts. This is problematic because lower HRV has been associated with cardiovascular morbidity and mortality. Aerobic exercise has been shown to improve HRV in the general population and in those with chronic diseases but its effectiveness in PLWH is unknown. PURPOSE: To evaluate the effects of 8-week aerobic exercise in PLWH on anti-retroviral therapy. METHODS: Twenty-six participants were randomly assigned to either a control group (no exercise) or an aerobic exercise group. Twenty-three participants completed the study. Resting HRV was measured for 5 minutes through an electrocardiogram. Measures included high frequency power (HF), low frequency/high frequency ratio (LF/HF ratio), low frequency power (LF), very low frequency power (VLF), standard deviation of normal-to-normal (NN) intervals (SDNN), and the square root of the mean squared differences of successive intervals (RMSSD). Estimated VO2peak was assessed through a 6-minute walk test (6-MWT) on a treadmill. Body fat percentage (BF%) was measured through air displacement plethysmography. The training group performed aerobic exercise 3 times per week (2 lab-based sessions and 1 home-based session per week) at 65%-75% of the heart rate max. Exercise duration was 30 minutes per session during the 1st week increasing to 45 minutes for weeks 2 to 8. RESULTS: Participants were 48.4 years old with a CD4 T-cell count of 681.9 cells/μL. There were no significant differences between groups in any of the HRV indices. However, SDNN (a marker of overall autonomic function) increased significantly in the exercise group (Pre: 46.97 ± 32.70 ms vs Post: 59.49 ± 37.20 ms, p= 0.036). There was a moderate correlation between SDNN and VO2peak (r= .53; p= 0.01). There were no significant differences in VO2peak or BF% between groups. CONCLUSIONS: While differences in HRV were not observed between groups, our data suggests that overall autonomic function can improve with aerobic exercise and these changes are associated with higher levels of VO2peak. These results advocate the importance of improvements in HRV as greater levels of HRV are associated to lower risk of CVD and mortality." @default.
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• W2954694503 date "2019-06-01" @default.
• W2954694503 modified "2023-09-23" @default.
• W2954694503 title "The Effects of Aerobic Exercise on Heart Rate Variability in People Living with HIV" @default.
• W2954694503 doi "https://doi.org/10.1249/01.mss.0000563460.51684.4d" @default.
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