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• W2954698528 abstract "Abstract Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from infected cells and tissues. Here, sequential long-acting slow-effective release antiviral therapy (LASER ART) and CRISPR-Cas9 demonstrate viral clearance in latent infectious reservoirs in HIV-1 infected humanized mice. HIV-1 subgenomic DNA fragments, spanning the long terminal repeats and the Gag gene, are excised in vivo, resulting in elimination of integrated proviral DNA; virus is not detected in blood, lymphoid tissue, bone marrow and brain by nested and digital-droplet PCR as well as RNAscope tests. No CRISPR-Cas9 mediated off-target effects are detected. Adoptive transfer of human immunocytes from dual treated, virus-free animals to uninfected humanized mice fails to produce infectious progeny virus. In contrast, HIV-1 is readily detected following sole LASER ART or CRISPR-Cas9 treatment. These data provide proof-of-concept that permanent viral elimination is possible." @default.
• W2954698528 created "2019-07-12" @default.
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• W2954698528 date "2019-07-02" @default.
• W2954698528 modified "2023-10-17" @default.
• W2954698528 title "Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice" @default.
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• W2954698528 doi "https://doi.org/10.1038/s41467-019-10366-y" @default.
• W2954698528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6606613" @default.

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