FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954710919> ?p ?o ?g. }

• W2954710919 abstract "Abstract Invasive pulmonary Aspergillosis is a leading cause of morbidity and mortality in immunosuppressed patients and treatment outcomes using oral antifungal triazoles remain suboptimal. Here we show that combining topical treatment using PC945, a novel inhaled triazole, with systemic treatment using known triazoles demonstrated synergistic antifungal effects against Aspergillus fumigatus (AF) in an in vitro human alveolus bilayer model and in the lungs of neutropenic immunocompromised mice. Combination treatment with apical PC945 and either basolateral posaconazole or voriconazole resulted in a synergistic interaction with potency improved over either compound as a monotherapy against both azole-susceptible and resistant AF invasion in vitro . Surprisingly there was little, or no synergistic interaction observed when apical and basolateral posaconazole or voriconazole were combined. In addition, repeated prophylactic treatment with PC945, but not posaconazole or voriconazole, showed superior effects to single prophylactic dose, suggesting tissue retention and/or accumulation of PC945. Furthermore, in mice infected with AF intranasally, 83% of animals treated with a combination of intranasal PC945 and oral posaconazole survived until day 7, while little protective effects were observed by either compound alone. Thus, the combination of a highly optimised topical triazole with oral triazoles potentially induces synergistic effects against AF infection." @default.
• W2954710919 created "2019-07-12" @default.
• W2954710919 creator A5004274360 @default.
• W2954710919 creator A5006005019 @default.
• W2954710919 creator A5028851882 @default.
• W2954710919 creator A5045731293 @default.
• W2954710919 creator A5049491293 @default.
• W2954710919 creator A5052004725 @default.
• W2954710919 creator A5057167410 @default.
• W2954710919 creator A5059124092 @default.
• W2954710919 creator A5072744544 @default.
• W2954710919 creator A5080770847 @default.
• W2954710919 date "2019-07-01" @default.
• W2954710919 modified "2023-10-11" @default.
• W2954710919 title "Antifungal synergy of a topical triazole, PC945, with a systemic triazole against respiratory Aspergillus fumigatus infection" @default.
• W2954710919 cites W1832443905 @default.
• W2954710919 cites W1968721620 @default.
• W2954710919 cites W1986907506 @default.
• W2954710919 cites W1989345554 @default.
• W2954710919 cites W2011819975 @default.
• W2954710919 cites W2012538966 @default.
• W2954710919 cites W2019236192 @default.
• W2954710919 cites W2037676380 @default.
• W2954710919 cites W2041015559 @default.
• W2954710919 cites W2087796927 @default.
• W2954710919 cites W2089384079 @default.
• W2954710919 cites W2114915363 @default.
• W2954710919 cites W2120068228 @default.
• W2954710919 cites W2127982840 @default.
• W2954710919 cites W2131778095 @default.
• W2954710919 cites W2141197648 @default.
• W2954710919 cites W2144677985 @default.
• W2954710919 cites W2144902349 @default.
• W2954710919 cites W2149403878 @default.
• W2954710919 cites W2285472607 @default.
• W2954710919 cites W2470291098 @default.
• W2954710919 cites W2589457164 @default.
• W2954710919 cites W2627081575 @default.
• W2954710919 cites W2697957195 @default.
• W2954710919 cites W2734590135 @default.
• W2954710919 cites W2792345387 @default.
• W2954710919 cites W2955015621 @default.
• W2954710919 doi "https://doi.org/10.1038/s41598-019-45890-w" @default.
• W2954710919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6603190" @default.
• W2954710919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31263150" @default.
• W2954710919 hasPublicationYear "2019" @default.
• W2954710919 type Work @default.
• W2954710919 sameAs 2954710919 @default.
• W2954710919 citedByCount "24" @default.
• W2954710919 countsByYear W29547109192020 @default.
• W2954710919 countsByYear W29547109192021 @default.
• W2954710919 countsByYear W29547109192022 @default.
• W2954710919 countsByYear W29547109192023 @default.
• W2954710919 crossrefType "journal-article" @default.
• W2954710919 hasAuthorship W2954710919A5004274360 @default.
• W2954710919 hasAuthorship W2954710919A5006005019 @default.
• W2954710919 hasAuthorship W2954710919A5028851882 @default.
• W2954710919 hasAuthorship W2954710919A5045731293 @default.
• W2954710919 hasAuthorship W2954710919A5049491293 @default.
• W2954710919 hasAuthorship W2954710919A5052004725 @default.
• W2954710919 hasAuthorship W2954710919A5057167410 @default.
• W2954710919 hasAuthorship W2954710919A5059124092 @default.
• W2954710919 hasAuthorship W2954710919A5072744544 @default.
• W2954710919 hasAuthorship W2954710919A5080770847 @default.
• W2954710919 hasBestOaLocation W29547109191 @default.
• W2954710919 hasConcept C178790620 @default.
• W2954710919 hasConcept C185592680 @default.
• W2954710919 hasConcept C203014093 @default.
• W2954710919 hasConcept C2776391196 @default.
• W2954710919 hasConcept C2777907353 @default.
• W2954710919 hasConcept C2778566413 @default.
• W2954710919 hasConcept C2779548794 @default.
• W2954710919 hasConcept C2779787849 @default.
• W2954710919 hasConcept C2780315139 @default.
• W2954710919 hasConcept C2780690907 @default.
• W2954710919 hasConcept C71924100 @default.
• W2954710919 hasConcept C86803240 @default.
• W2954710919 hasConcept C89423630 @default.
• W2954710919 hasConcept C98274493 @default.
• W2954710919 hasConceptScore W2954710919C178790620 @default.
• W2954710919 hasConceptScore W2954710919C185592680 @default.
• W2954710919 hasConceptScore W2954710919C203014093 @default.
• W2954710919 hasConceptScore W2954710919C2776391196 @default.
• W2954710919 hasConceptScore W2954710919C2777907353 @default.
• W2954710919 hasConceptScore W2954710919C2778566413 @default.
• W2954710919 hasConceptScore W2954710919C2779548794 @default.
• W2954710919 hasConceptScore W2954710919C2779787849 @default.
• W2954710919 hasConceptScore W2954710919C2780315139 @default.
• W2954710919 hasConceptScore W2954710919C2780690907 @default.
• W2954710919 hasConceptScore W2954710919C71924100 @default.
• W2954710919 hasConceptScore W2954710919C86803240 @default.
• W2954710919 hasConceptScore W2954710919C89423630 @default.
• W2954710919 hasConceptScore W2954710919C98274493 @default.
• W2954710919 hasIssue "1" @default.
• W2954710919 hasLocation W29547109191 @default.
• W2954710919 hasLocation W29547109192 @default.
• W2954710919 hasLocation W29547109193 @default.
• W2954710919 hasOpenAccess W2954710919 @default.
• W2954710919 hasPrimaryLocation W29547109191 @default.
• W2954710919 hasRelatedWork W1973282809 @default.

• next