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- W2954711897 abstract "背景 在欧洲和中国进行Elecsys®胃泌素释放肽前体(ProGRP)免疫检测的多中心评估研究。方法 在欧洲的3个中心和中国的2个中心,在肺癌中,通过不精密度、稳定性、方法学比较和鉴别诊断能力来评价该检测法。结果 5个分析物浓度的中间不精密度范围为变异系数:2.2%-6.0%。在不同储存条件下,血浆和血清样本均显示出良好的稳定性。在血浆中Elecsys®和ARCHITECT检测(斜率1.02,截距-2.72 pg/mL)之间表现出良好的相关性。同时,Elecsys®检测在血清和血浆样本之间表现出良好的相关性(斜率0.93,截距2.35 pg/mL;相关系数0.97)。ProGRP作为不受种族、年龄、性别或吸烟史相关影响的检测手段,可鉴别小细胞和非小细胞肺癌(NSCLC);截断值为84 pg/mL时,曲线下面积为0.90,95%CI: 0.87-0.93;敏感性为78.3%,特异性为95%。ProGRP浓度中位数在良性病变(38 pg/mL)、其他恶性肿瘤(40 pg/mL)或NSCLC(39 pg/mL)中较低,而在3期以上慢性肾脏疾病中浓度较高(>100 pg/mL)。结论 Elecsys® ProGRP检测在血清和血浆中稳定性增加,较现有检测法明显更具优势。ProGRP检测在中国的首次评价在不同种族中显示出相当的鉴别能力。." @default.
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- W2954711897 date "2017-08-20" @default.
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- W2954711897 title "[Multicenter Evaluation of A New Progastrin-releasing Peptide (ProGRP) Immunoassay across Europe and China]." @default.
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- W2954711897 doi "https://doi.org/10.3779/j.issn.1009-3419.2017.08.12" @default.
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