FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954718> ?p ?o ?g. }

• W2954718 abstract "One of the major issues for antibody treatment is enhancement of efficacy. Recent studies have highlighted the important role of effector functions in improvement of antibody therapy. Among effector functions, complement-dependent cytotoxicity (CDC), which induces cell lysis by a cascade of activation triggered by the binding of C1q subunits to the Fc regions of antibodies bound to the cell surface, is part of the mechanism of several antibody therapies. CDC can be modulated by either Fc isotype engineering or Fc genetic mutations or Fc glycosylation profile modifications. To evaluate the impact of such modifications on CDC, we describe a luminescence method based on ATP measurement to estimate tumor damaged cells and a flow cytometry method to evaluate the binding of C1q on the Fc region and the binding of C4b on cell surface. The luminescence method coupled with complement protein analysis by flow cytometry encompasses all needed methods to evaluate antibody ability to trigger CDC." @default.
• W2954718 created "2016-06-24" @default.
• W2954718 creator A5020433108 @default.
• W2954718 creator A5040900281 @default.
• W2954718 creator A5091616258 @default.
• W2954718 date "2013-01-01" @default.
• W2954718 modified "2023-09-27" @default.
• W2954718 title "Evaluation of Complement-Dependent Cytotoxicity Using ATP Measurement and C1q/C4b Binding" @default.
• W2954718 cites W1589026573 @default.
• W2954718 cites W1984342356 @default.
• W2954718 cites W1985102822 @default.
• W2954718 cites W2027374210 @default.
• W2954718 cites W2027732045 @default.
• W2954718 cites W2040426470 @default.
• W2954718 cites W2052491267 @default.
• W2954718 cites W2065419141 @default.
• W2954718 cites W2068553332 @default.
• W2954718 cites W2071181996 @default.
• W2954718 cites W2105141160 @default.
• W2954718 cites W2158803162 @default.
• W2954718 cites W2168109319 @default.
• W2954718 cites W2168648203 @default.
• W2954718 cites W33733012 @default.
• W2954718 cites W60759546 @default.
• W2954718 doi "https://doi.org/10.1007/978-1-62703-327-5_20" @default.
• W2954718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23475729" @default.
• W2954718 hasPublicationYear "2013" @default.
• W2954718 type Work @default.
• W2954718 sameAs 2954718 @default.
• W2954718 citedByCount "8" @default.
• W2954718 countsByYear W29547182014 @default.
• W2954718 countsByYear W29547182016 @default.
• W2954718 countsByYear W29547182017 @default.
• W2954718 countsByYear W29547182019 @default.
• W2954718 countsByYear W29547182020 @default.
• W2954718 crossrefType "book-chapter" @default.
• W2954718 hasAuthorship W2954718A5020433108 @default.
• W2954718 hasAuthorship W2954718A5040900281 @default.
• W2954718 hasAuthorship W2954718A5091616258 @default.
• W2954718 hasConcept C109316439 @default.
• W2954718 hasConcept C111684460 @default.
• W2954718 hasConcept C125823703 @default.
• W2954718 hasConcept C1491633281 @default.
• W2954718 hasConcept C153911025 @default.
• W2954718 hasConcept C159654299 @default.
• W2954718 hasConcept C185592680 @default.
• W2954718 hasConcept C202751555 @default.
• W2954718 hasConcept C203014093 @default.
• W2954718 hasConcept C2777726029 @default.
• W2954718 hasConcept C2777991845 @default.
• W2954718 hasConcept C40677261 @default.
• W2954718 hasConcept C51785407 @default.
• W2954718 hasConcept C542903549 @default.
• W2954718 hasConcept C553184892 @default.
• W2954718 hasConcept C55493867 @default.
• W2954718 hasConcept C57409179 @default.
• W2954718 hasConcept C86803240 @default.
• W2954718 hasConcept C95444343 @default.
• W2954718 hasConceptScore W2954718C109316439 @default.
• W2954718 hasConceptScore W2954718C111684460 @default.
• W2954718 hasConceptScore W2954718C125823703 @default.
• W2954718 hasConceptScore W2954718C1491633281 @default.
• W2954718 hasConceptScore W2954718C153911025 @default.
• W2954718 hasConceptScore W2954718C159654299 @default.
• W2954718 hasConceptScore W2954718C185592680 @default.
• W2954718 hasConceptScore W2954718C202751555 @default.
• W2954718 hasConceptScore W2954718C203014093 @default.
• W2954718 hasConceptScore W2954718C2777726029 @default.
• W2954718 hasConceptScore W2954718C2777991845 @default.
• W2954718 hasConceptScore W2954718C40677261 @default.
• W2954718 hasConceptScore W2954718C51785407 @default.
• W2954718 hasConceptScore W2954718C542903549 @default.
• W2954718 hasConceptScore W2954718C553184892 @default.
• W2954718 hasConceptScore W2954718C55493867 @default.
• W2954718 hasConceptScore W2954718C57409179 @default.
• W2954718 hasConceptScore W2954718C86803240 @default.
• W2954718 hasConceptScore W2954718C95444343 @default.
• W2954718 hasLocation W29547181 @default.
• W2954718 hasLocation W29547182 @default.
• W2954718 hasOpenAccess W2954718 @default.
• W2954718 hasPrimaryLocation W29547181 @default.
• W2954718 hasRelatedWork W1032555108 @default.
• W2954718 hasRelatedWork W144773976 @default.
• W2954718 hasRelatedWork W1969824500 @default.
• W2954718 hasRelatedWork W1973718144 @default.
• W2954718 hasRelatedWork W2046596184 @default.
• W2954718 hasRelatedWork W2076400221 @default.
• W2954718 hasRelatedWork W2084452069 @default.
• W2954718 hasRelatedWork W2168313542 @default.
• W2954718 hasRelatedWork W2190603070 @default.
• W2954718 hasRelatedWork W2468616401 @default.
• W2954718 hasRelatedWork W2509039973 @default.
• W2954718 hasRelatedWork W2572862655 @default.
• W2954718 hasRelatedWork W2774572129 @default.
• W2954718 hasRelatedWork W2913777893 @default.
• W2954718 hasRelatedWork W2917197215 @default.
• W2954718 hasRelatedWork W2995155483 @default.
• W2954718 hasRelatedWork W3084412720 @default.
• W2954718 hasRelatedWork W3102332556 @default.
• W2954718 hasRelatedWork W3197031641 @default.

• next