Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954722802> ?p ?o ?g. }
- W2954722802 abstract "Abstract Cyclic AMP (cAMP) is involved in multiple biological processes. However, little is known about its role in shaping immunity. Here we show that cAMP-PKA-CREB signaling (a pattern recognition receptor [PRR]-independent) regulates conventional type-2 Dendritic Cells (cDC2s), but not cDC1s and reprograms their Th17-inducing properties via repression of IRF4 and KLF4, transcription factors (TFs) for Th2 induction. Genetic loss of IRF4 phenocopies the effects of cAMP signaling on Th17-induction, indicating that the cAMP effect is secondary to repression of IRF4. Moreover, signaling in cDC2s by a PRR-dependent microbial product, curdlan, represses IRF4 and KLF4, resulting in a pro-Th17 phenotype. These results define a novel signaling pathway by which cDC2s display plasticity and provide a new molecular basis for the novel cDC2 and cDC17 classification. In addition, the data reveal that cAMP signaling can alter DCs function and fate by repressing IRF4 and KLF4, a pathway that can be harnessed for immuno-regulation." @default.
- W2954722802 created "2019-07-12" @default.
- W2954722802 creator A5003590800 @default.
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- W2954722802 creator A5082444966 @default.
- W2954722802 creator A5088270555 @default.
- W2954722802 date "2019-06-28" @default.
- W2954722802 modified "2023-09-26" @default.
- W2954722802 title "Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses" @default.
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