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- W2954773114 abstract "The parameters characterizing the formation of complexes with albumin (in particular, human serum albumin (HSA)) are fundamental for the characterization of a drug for commercialization purposes and for the determination of common pharmacokinetic parameters. Electrochemical methods appear particularly attractive for the determination of the complexation constant, complex stoichiometry, and percentage of free/bound drug, due to the ease of operation and the wide availability. In this article, we propose an electrochemical method based on differential pulse voltammetry for the determination of albumin-drug interaction parameters, including the replacement of the drug-albumin adduct by a competitive compound, sulfanilamide. The formation of either single or multiple complexes between the considered drug and albumin has been considered. Typically, the method operates with a glassy carbon electrode in NaCl 0.9% as the supporting electrolyte." @default.
- W2954773114 created "2019-07-12" @default.
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- W2954773114 date "2019-06-28" @default.
- W2954773114 modified "2023-09-27" @default.
- W2954773114 title "Voltammetric Determination of Binding Constant and Stoichiometry of Albumin (Human, Bovine, Ovine)–Drug Complexes" @default.
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- W2954773114 doi "https://doi.org/10.1021/acs.analchem.9b02088" @default.
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