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- W2954774578 endingPage "110649" @default.
- W2954774578 startingPage "110649" @default.
- W2954774578 abstract "Testicular aging is linked to histological, morphological and functional alterations. In the present study, we investigated whether aging affects the inflammatory and oxidative status in the testis by comparing young adult, middle-aged adult and aged hamsters. The Syrian hamster, a thoroughly studied seasonal breeder, was chosen as the experimental model since it allows further investigations on the role of photoperiod and melatonin in testicular aging with a minimal impact of the experimental intervention on the animal well-being and the subsequent results achieved. In testes of aged hamsters, we found a decrease in melatonin concentration, a thickening of the wall of the seminiferous tubules as well as a significant increase in IL-1β, NLRP3 and cyclooxygenase 2 expression, PGD2 production, macrophages numbers, lipid peroxidation and anti-oxidant enzyme catalase levels. Interestingly, when aged hamsters were transferred from a long day (LD) to a short day (SD) photoperiod for 16 weeks, testicular melatonin concentration increased while local inflammatory processes and oxidative stress were clearly reduced. Overall, these results indicate that melatonin might display anti-inflammatory and anti-oxidant capacities in the aged testes." @default.
- W2954774578 created "2019-07-12" @default.
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- W2954774578 date "2019-09-01" @default.
- W2954774578 modified "2023-10-16" @default.
- W2954774578 title "Aging in the Syrian hamster testis: Inflammatory-oxidative status and the impact of photoperiod" @default.
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- W2954774578 doi "https://doi.org/10.1016/j.exger.2019.110649" @default.
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- W2954774578 hasPublicationYear "2019" @default.
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