FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954793899> ?p ?o ?g. }

• W2954793899 endingPage "3637" @default.
• W2954793899 startingPage "3637" @default.
• W2954793899 abstract "Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II detoxification enzymes involved in glycosylation of lipophilic endobiotics and xenobiotics, including phytoalexins. Nicotine, one of the most abundant secondary plant metabolites in tobacco, is highly toxic to herbivorous insects. Plant-herbivore competition is the major impetus for the evolution of large superfamilies of UGTs and other detoxification enzymes. However, UGT functions in green peach aphid (Myzus persicae) adaptation are unknown. In this study, we show that UGT inhibitors (sulfinpyrazone and 5-nitrouracil) significantly increased nicotine toxicity in M. persicae nicotianae, suggesting that UGTs may be involved in nicotine tolerance. In total, 101 UGT transcripts identified in the M. persicae genome/transcriptome were renamed according to the UGT Nomenclature Committee guidelines and grouped into 11 families, UGT329, UGT330, UGT339, UGT341–UGT345, and UGT348–UGT350, with UGT344 containing the most (57). Ten UGTs (UGT330A3, UGT339A2, UGT341A6, UGT342B3, UGT343C3, UGT344D5, UGT344D8, UGT348A3, UGT349A3, and UGT350A3) were highly expressed in M. persicae nicotianae compared to M. persicae sensu stricto. Knockdown of four UGTs (UGT330A3, UGT344D5, UGT348A3, and UGT349A3) significantly increased M. persicae nicotianae sensitivity to nicotine, suggesting that UGT expression in this subspecies may be associated with nicotine tolerance and thus host adaptation. This study reveals possible UGTs relevant to nicotine adaptation in tobacco-consuming M. persicae nicotianae, and the findings will facilitate further validation of the roles of these UGTs in nicotine tolerance." @default.
• W2954793899 created "2019-07-12" @default.
• W2954793899 creator A5006512159 @default.
• W2954793899 creator A5018634718 @default.
• W2954793899 creator A5036735358 @default.
• W2954793899 creator A5049950020 @default.
• W2954793899 creator A5063701397 @default.
• W2954793899 date "2019-07-25" @default.
• W2954793899 modified "2023-09-23" @default.
• W2954793899 title "Characterization of UDP-Glucuronosyltransferases and the Potential Contribution to Nicotine Tolerance in Myzus persicae" @default.
• W2954793899 cites W1577577364 @default.
• W2954793899 cites W1581177169 @default.
• W2954793899 cites W1608757365 @default.
• W2954793899 cites W1973145015 @default.
• W2954793899 cites W1983617242 @default.
• W2954793899 cites W1995727180 @default.
• W2954793899 cites W2005516932 @default.
• W2954793899 cites W2017548405 @default.
• W2954793899 cites W2025734856 @default.
• W2954793899 cites W2062046551 @default.
• W2954793899 cites W2066086354 @default.
• W2954793899 cites W2080895359 @default.
• W2954793899 cites W2081468521 @default.
• W2954793899 cites W2088002666 @default.
• W2954793899 cites W2098086227 @default.
• W2954793899 cites W2108244474 @default.
• W2954793899 cites W2119378686 @default.
• W2954793899 cites W2120083690 @default.
• W2954793899 cites W2121440246 @default.
• W2954793899 cites W2121588551 @default.
• W2954793899 cites W2132422681 @default.
• W2954793899 cites W2136314546 @default.
• W2954793899 cites W2155979538 @default.
• W2954793899 cites W2162785377 @default.
• W2954793899 cites W2266325332 @default.
• W2954793899 cites W2422335435 @default.
• W2954793899 cites W2551899720 @default.
• W2954793899 cites W2611493931 @default.
• W2954793899 cites W2760827040 @default.
• W2954793899 cites W2795478731 @default.
• W2954793899 cites W2888698178 @default.
• W2954793899 doi "https://doi.org/10.3390/ijms20153637" @default.
• W2954793899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6695686" @default.
• W2954793899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31349586" @default.
• W2954793899 hasPublicationYear "2019" @default.
• W2954793899 type Work @default.
• W2954793899 sameAs 2954793899 @default.
• W2954793899 citedByCount "24" @default.
• W2954793899 countsByYear W29547938992020 @default.
• W2954793899 countsByYear W29547938992021 @default.
• W2954793899 countsByYear W29547938992022 @default.
• W2954793899 countsByYear W29547938992023 @default.
• W2954793899 crossrefType "journal-article" @default.
• W2954793899 hasAuthorship W2954793899A5006512159 @default.
• W2954793899 hasAuthorship W2954793899A5018634718 @default.
• W2954793899 hasAuthorship W2954793899A5036735358 @default.
• W2954793899 hasAuthorship W2954793899A5049950020 @default.
• W2954793899 hasAuthorship W2954793899A5063701397 @default.
• W2954793899 hasBestOaLocation W29547938991 @default.
• W2954793899 hasConcept C169760540 @default.
• W2954793899 hasConcept C181199279 @default.
• W2954793899 hasConcept C2775976403 @default.
• W2954793899 hasConcept C2777066214 @default.
• W2954793899 hasConcept C2779547902 @default.
• W2954793899 hasConcept C2781278898 @default.
• W2954793899 hasConcept C55493867 @default.
• W2954793899 hasConcept C59822182 @default.
• W2954793899 hasConcept C86803240 @default.
• W2954793899 hasConcept C87644729 @default.
• W2954793899 hasConceptScore W2954793899C169760540 @default.
• W2954793899 hasConceptScore W2954793899C181199279 @default.
• W2954793899 hasConceptScore W2954793899C2775976403 @default.
• W2954793899 hasConceptScore W2954793899C2777066214 @default.
• W2954793899 hasConceptScore W2954793899C2779547902 @default.
• W2954793899 hasConceptScore W2954793899C2781278898 @default.
• W2954793899 hasConceptScore W2954793899C55493867 @default.
• W2954793899 hasConceptScore W2954793899C59822182 @default.
• W2954793899 hasConceptScore W2954793899C86803240 @default.
• W2954793899 hasConceptScore W2954793899C87644729 @default.
• W2954793899 hasIssue "15" @default.
• W2954793899 hasLocation W29547938991 @default.
• W2954793899 hasLocation W29547938992 @default.
• W2954793899 hasLocation W29547938993 @default.
• W2954793899 hasLocation W29547938994 @default.
• W2954793899 hasLocation W29547938995 @default.
• W2954793899 hasOpenAccess W2954793899 @default.
• W2954793899 hasPrimaryLocation W29547938991 @default.
• W2954793899 hasRelatedWork W1528149948 @default.
• W2954793899 hasRelatedWork W1550256140 @default.
• W2954793899 hasRelatedWork W1966363271 @default.
• W2954793899 hasRelatedWork W2009445263 @default.
• W2954793899 hasRelatedWork W2081937690 @default.
• W2954793899 hasRelatedWork W2103389055 @default.
• W2954793899 hasRelatedWork W2163874015 @default.
• W2954793899 hasRelatedWork W2840281824 @default.
• W2954793899 hasRelatedWork W2891213292 @default.
• W2954793899 hasRelatedWork W2970851202 @default.
• W2954793899 hasVolume "20" @default.

• next