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• W2954804437 endingPage "87" @default.
• W2954804437 startingPage "81" @default.
• W2954804437 abstract "Despite the major progresses in comprehending the mechanisms of tumor immunosurveillance and the role of innate and adaptive immune systems in recent years, there are still a number of obstacles hindering successful and effective immunotherapy of cancer. Such obstacles have been mainly attributed to the ability of tumors in creating a tolerant microenvironment and exploiting a plethora of immunosuppressive factors that counter effective immune responses against tumor cells. Here we represent a new insight into probable links between immune system disability with metabolism and chronic psychological stress which is beyond the other strategies recruited by tumors to thwart tumor immunosurveillance. In addition, we underscore the prominent role of improper innate immune responses as one of the underlying causes of either pro-tumorigenic capability or tumor immunosurveillance failure. However the insufficiency of stimulatory factors in immune responses is a major fact leading to tumor survival, metabolic suppression of immune cells in tumor microenvironment, as well as the negative influences of chronic stress and depression in cancer patients are important parameters amplifying disability of immune responses which have mostly been underestimated in cancer immunotherapy. Stress-related catecholamines are suggested as immunosuppressive factors. In addition, tumor cells have distinct metabolic pathways and secrete various metabolites in the tumor microenvironment which may inhibit T cells activity. We believe that simultaneous control of metabolic and psychological negative influences on the tumor immunosurveillance, along with addressing the weak aspects of innate and adaptive immune responses in cancer immunotherapy may result in more successful treatment of tumors." @default.
• W2954804437 created "2019-07-12" @default.
• W2954804437 creator A5008815285 @default.
• W2954804437 creator A5045881386 @default.
• W2954804437 creator A5064862200 @default.
• W2954804437 date "2019-08-01" @default.
• W2954804437 modified "2023-09-25" @default.
• W2954804437 title "Major fundamental factors hindering immune system in defense against tumor cells: The link between insufficiency of innate immune responses, metabolism, and neurotransmitters with effector immune cells disability" @default.
• W2954804437 cites W1498187417 @default.
• W2954804437 cites W1498931318 @default.
• W2954804437 cites W1544965678 @default.
• W2954804437 cites W1572122915 @default.
• W2954804437 cites W1604141497 @default.
• W2954804437 cites W1615432648 @default.
• W2954804437 cites W1878777740 @default.
• W2954804437 cites W1966921390 @default.
• W2954804437 cites W1969087061 @default.
• W2954804437 cites W1974056979 @default.
• W2954804437 cites W1975701262 @default.
• W2954804437 cites W1976199086 @default.
• W2954804437 cites W1977209251 @default.
• W2954804437 cites W1986354050 @default.
• W2954804437 cites W1988209623 @default.
• W2954804437 cites W1990602451 @default.
• W2954804437 cites W1994252478 @default.
• W2954804437 cites W2002820793 @default.
• W2954804437 cites W2003173977 @default.
• W2954804437 cites W2016570620 @default.
• W2954804437 cites W2019214729 @default.
• W2954804437 cites W2026429915 @default.
• W2954804437 cites W2033577259 @default.
• W2954804437 cites W2034754688 @default.
• W2954804437 cites W2035192859 @default.
• W2954804437 cites W2041858687 @default.
• W2954804437 cites W2043793366 @default.
• W2954804437 cites W2044757050 @default.
• W2954804437 cites W2046972425 @default.
• W2954804437 cites W2053763669 @default.
• W2954804437 cites W2056709367 @default.
• W2954804437 cites W2059247237 @default.
• W2954804437 cites W2060878129 @default.
• W2954804437 cites W2067971586 @default.
• W2954804437 cites W2072451938 @default.
• W2954804437 cites W2074344965 @default.
• W2954804437 cites W2086517030 @default.
• W2954804437 cites W2093585033 @default.
• W2954804437 cites W2100039832 @default.
• W2954804437 cites W2111428527 @default.
• W2954804437 cites W2111444310 @default.
• W2954804437 cites W2116554142 @default.
• W2954804437 cites W2117573747 @default.
• W2954804437 cites W2123944872 @default.
• W2954804437 cites W2127903252 @default.
• W2954804437 cites W2128838531 @default.
• W2954804437 cites W2131199230 @default.
• W2954804437 cites W2132869887 @default.
• W2954804437 cites W2133449490 @default.
• W2954804437 cites W2135530652 @default.
• W2954804437 cites W2143112776 @default.
• W2954804437 cites W2143772132 @default.
• W2954804437 cites W2146934919 @default.
• W2954804437 cites W2149437353 @default.
• W2954804437 cites W2150678612 @default.
• W2954804437 cites W2151313580 @default.
• W2954804437 cites W2153153465 @default.
• W2954804437 cites W2154280336 @default.
• W2954804437 cites W2155759076 @default.
• W2954804437 cites W2156106286 @default.
• W2954804437 cites W2161585699 @default.
• W2954804437 cites W2162119603 @default.
• W2954804437 cites W2165897342 @default.
• W2954804437 cites W2167106423 @default.
• W2954804437 cites W2196491217 @default.
• W2954804437 cites W2254024193 @default.
• W2954804437 cites W2289054941 @default.
• W2954804437 cites W2294143173 @default.
• W2954804437 cites W2320349682 @default.
• W2954804437 cites W2341604280 @default.
• W2954804437 cites W2395771897 @default.
• W2954804437 cites W2397189416 @default.
• W2954804437 cites W2407603036 @default.
• W2954804437 cites W2505201035 @default.
• W2954804437 cites W2507334943 @default.
• W2954804437 cites W2530067632 @default.
• W2954804437 cites W2536322725 @default.
• W2954804437 cites W2553747999 @default.
• W2954804437 cites W2605482562 @default.
• W2954804437 cites W2727838564 @default.
• W2954804437 cites W2748524892 @default.
• W2954804437 cites W2788268371 @default.
• W2954804437 cites W2793102213 @default.
• W2954804437 cites W2889646458 @default.
• W2954804437 cites W2889950184 @default.
• W2954804437 cites W2909218971 @default.
• W2954804437 cites W900373682 @default.
• W2954804437 doi "https://doi.org/10.1016/j.imlet.2019.06.008" @default.
• W2954804437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31260743" @default.
• W2954804437 hasPublicationYear "2019" @default.

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