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• W2954807841 endingPage "691" @default.
• W2954807841 startingPage "681" @default.
• W2954807841 abstract "Introduction: Klebsiella pneumoniae (KP) are a leading cause of healthcare-associated infections. The dramatic increase in microbial resistance to third-generation cephalosporin and carbapenem 'front line' antimicrobial agents and the paucity of new antimicrobials have left clinicians with few therapeutic options and resulted in increased morbidity and mortality. Vaccines may reduce the incidence of infections thereby reducing the necessity for antimicrobials and are not subject to antimicrobial resistance mechanisms. Areas covered: We review whole cell, subunit, capsular polysaccharide (CPS), O polysaccharide (OPS) and conjugate vaccines against KP infection, as well as alternative KP vaccine platforms. Expert opinion: Vaccine-induced antibodies to KP CPS have been protective in preclinical studies, but the number of CPS types (>77) makes vaccines against this virulence factor less feasible. Since four OPS serotypes account of ~80% of invasive KP infections and anti-OPS antibodies are also protective in preclinical studies, both OPS-based conjugate and multiple antigen presenting system (MAPS) vaccines are in active development. Vaccines based on other KP virulence factors, such as outer membrane proteins, type 3 fimbriae (MrkA) and siderophores are at earlier stages of development. Novel strategies for the clinical testing of KP vaccines need to be developed." @default.
• W2954807841 created "2019-07-12" @default.
• W2954807841 creator A5003385022 @default.
• W2954807841 creator A5013629650 @default.
• W2954807841 creator A5051877443 @default.
• W2954807841 creator A5070409967 @default.
• W2954807841 date "2019-06-28" @default.
• W2954807841 modified "2023-10-10" @default.
• W2954807841 title "Progress towards the development of Klebsiella vaccines" @default.
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