FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954846543> ?p ?o ?g. }

• W2954846543 abstract "Abstract Introduction The volume of the striatal structures has been associated with disease progression in individuals with Huntington's disease (HD) from North America, Europe, and Australia. However, it is not known whether the gray matter (GM) volume in the striatum is also sensitive in differentiating vulnerability from disease manifestation in HD families from a South‐American region known to have high incidence of the disease. In addition, the association of enlarged brain perivascular spaces (PVS) with cognitive, behavioral, and motor symptoms of HD is unknown. Materials and Methods We have analyzed neuroimaging indicators of global atrophy, PVS burden, and GM tissue volume in the basal ganglia and thalami, in relation to behavioral, motor, and cognitive scores, in 15 HD patients with overt disease manifestation and 14 first‐degree relatives not genetically tested, which represent a vulnerable group, from the region of Magdalena, Colombia. Results Poor fluid intelligence as per the Raven's Standard Progressive Matrices was associated with global brain atrophy ( p = 0.002) and PVS burden ( p ≤ 0.02) in HD patients, where the GM volume in all subcortical structures, with the exception of the right globus pallidus, was associated with motor or cognitive scores. Only the GM volume in the right putamen was associated with envy and MOCA scores ( p = 0.008 and 0.015 respectively) in first‐degree relatives. Conclusion Striatal GM volume, global brain atrophy and PVS burden may serve as differential indicators of disease manifestation in HD. The Raven's Standard Progressive Matrices could be a cognitive test worth to consider in the differentiation of vulnerability versus overt disease in HD." @default.
• W2954846543 created "2019-07-12" @default.
• W2954846543 creator A5014213472 @default.
• W2954846543 creator A5017493705 @default.
• W2954846543 creator A5025285051 @default.
• W2954846543 creator A5037111555 @default.
• W2954846543 creator A5050169867 @default.
• W2954846543 creator A5055109212 @default.
• W2954846543 creator A5070531285 @default.
• W2954846543 creator A5082919366 @default.
• W2954846543 date "2019-07-05" @default.
• W2954846543 modified "2023-10-03" @default.
• W2954846543 title "Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington's disease" @default.
• W2954846543 cites W1545350032 @default.
• W2954846543 cites W1591042602 @default.
• W2954846543 cites W1595360136 @default.
• W2954846543 cites W1599493014 @default.
• W2954846543 cites W1731947656 @default.
• W2954846543 cites W1978697238 @default.
• W2954846543 cites W1981466739 @default.
• W2954846543 cites W1995119071 @default.
• W2954846543 cites W2006760403 @default.
• W2954846543 cites W2022312076 @default.
• W2954846543 cites W2027946127 @default.
• W2954846543 cites W2034297927 @default.
• W2954846543 cites W2037258163 @default.
• W2954846543 cites W2039693650 @default.
• W2954846543 cites W2047195263 @default.
• W2954846543 cites W2054509077 @default.
• W2954846543 cites W2055962836 @default.
• W2954846543 cites W2056792865 @default.
• W2954846543 cites W2059982830 @default.
• W2954846543 cites W2069914007 @default.
• W2954846543 cites W2080793083 @default.
• W2954846543 cites W2102560654 @default.
• W2954846543 cites W2104901197 @default.
• W2954846543 cites W2106849104 @default.
• W2954846543 cites W2113661629 @default.
• W2954846543 cites W2115870221 @default.
• W2954846543 cites W2117471869 @default.
• W2954846543 cites W2121684860 @default.
• W2954846543 cites W2122481791 @default.
• W2954846543 cites W2124660038 @default.
• W2954846543 cites W2129250133 @default.
• W2954846543 cites W2150921243 @default.
• W2954846543 cites W2151627270 @default.
• W2954846543 cites W2158742097 @default.
• W2954846543 cites W2163646263 @default.
• W2954846543 cites W2165317828 @default.
• W2954846543 cites W2165758561 @default.
• W2954846543 cites W2231066512 @default.
• W2954846543 cites W2333187255 @default.
• W2954846543 cites W2418434019 @default.
• W2954846543 cites W2475470216 @default.
• W2954846543 cites W2541110819 @default.
• W2954846543 cites W2586191971 @default.
• W2954846543 cites W2588265422 @default.
• W2954846543 cites W2603002581 @default.
• W2954846543 cites W2609254407 @default.
• W2954846543 cites W2611816823 @default.
• W2954846543 cites W2741564219 @default.
• W2954846543 cites W2742497781 @default.
• W2954846543 cites W2745482791 @default.
• W2954846543 cites W2757427369 @default.
• W2954846543 cites W2758326279 @default.
• W2954846543 cites W2765282570 @default.
• W2954846543 cites W2766151438 @default.
• W2954846543 cites W2783838682 @default.
• W2954846543 cites W2898913093 @default.
• W2954846543 cites W2914584287 @default.
• W2954846543 cites W4239773101 @default.
• W2954846543 doi "https://doi.org/10.1002/brb3.1343" @default.
• W2954846543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6710228" @default.
• W2954846543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31276317" @default.
• W2954846543 hasPublicationYear "2019" @default.
• W2954846543 type Work @default.
• W2954846543 sameAs 2954846543 @default.
• W2954846543 citedByCount "5" @default.
• W2954846543 countsByYear W29548465432020 @default.
• W2954846543 countsByYear W29548465432021 @default.
• W2954846543 countsByYear W29548465432023 @default.
• W2954846543 crossrefType "journal-article" @default.
• W2954846543 hasAuthorship W2954846543A5014213472 @default.
• W2954846543 hasAuthorship W2954846543A5017493705 @default.
• W2954846543 hasAuthorship W2954846543A5025285051 @default.
• W2954846543 hasAuthorship W2954846543A5037111555 @default.
• W2954846543 hasAuthorship W2954846543A5050169867 @default.
• W2954846543 hasAuthorship W2954846543A5055109212 @default.
• W2954846543 hasAuthorship W2954846543A5070531285 @default.
• W2954846543 hasAuthorship W2954846543A5082919366 @default.
• W2954846543 hasBestOaLocation W29548465431 @default.
• W2954846543 hasConcept C126838900 @default.
• W2954846543 hasConcept C142724271 @default.
• W2954846543 hasConcept C143409427 @default.
• W2954846543 hasConcept C15744967 @default.
• W2954846543 hasConcept C169760540 @default.
• W2954846543 hasConcept C169900460 @default.
• W2954846543 hasConcept C173354102 @default.
• W2954846543 hasConcept C2778187257 @default.
• W2954846543 hasConcept C2779134260 @default.

• next