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• W2954859097 abstract "Recent advances in medical engineering have enabled dialyzers for hemodialysis (HD) patients to remove larger-size molecules during HD. Dialyzers made of superhigh-flux (SHF) membranes have a potential to filtrate middle-size and larger middle-size molecules than those made of high-flux (HF) membranes. This study was conducted to clarify a beneficial effect of SHF membranes in laboratory and clinical features of patients undergoing maintenance HD. Characteristics of the dialyzers investigated in this study were as follows; both dialyzers were made of polysulfone membranes and the effective surface area, ultrafiltration coefficient and beta-2-microglobulin clearance of HF and SHF dialyzers were 1.2m², 42 ml/h/mmHg, 52 ml/min and 1.1m², 46 ml/h/mmHg, 70 ml/min, respectively. Reduction rates of serum concentrations of small-size, middle-size and larger middle-size molecules were measured at the beginning and at the end of the first-week dialysis treatments at 0, 3, 6, 9, 12 and 18 months after changing the dialyzers from HF to SHF membranes in 6 female outpatients undergoing 3-time-maintenance HD per week regularly. Serum concentrations of urea (MW; 60 Da), creatinine (MW; 113 Da) and uric acid (MW; 168 Da) as small-size molecules, beta-2-microglobulin (MW; 11,800 Da) as a middle-size molecule, alpha-1-microglobulin (MW; 33,000 Da) as a larger middle-size molecule and albumin (MW; 66,000 Da) as a large-size molecule were measured. In the same way serum concentrations of sodium (Na), potassium (K), calcium (Ca), inorganic phosphorus (iP), magnesium (Mg), choline esterase (ChE), total cholesterol (TC), triglycerides (TG) and total protein (TP) were measured at the begging of each HD mentioned above and evaluated nutritional status of HD patients. Nutritional status of HD patients were also estimated by measuring arm circumference (AC), calf circumference (CC), triceps skinfold thickness (TSFT), subscapular skinfold thickness (SSFT), mid-upper arm muscle circumference (AMC) and mid-upper arm muscle area (AMA). Subjective assessment was obtained by interviewing improvement or ingravescence of subjective symptoms in the daily lives of the HD patients. Statistical analysis was performed using JMP 9 and p<0.05 was considered to be significant. The age and the HD duration of the subjects were 73.5±6.7 years old and 97.5±61.5 months, respectively (mean±SD) and primary diseases were 2 cases of each diabetic kidney disease, chronic glomerulonephritis and nephrosclerosis. We found no significant alteration in the reduction rates of small-size and middle-size molecules, however, that of alpha-1-microglobulin, a larger middle-size molecule, was significantly increased. There was no significant alteration in the serum concentrations of Na, K, Ca, iP, Mg, ChE, TC, TG and TP. The values of AC, CC, TSFT, SSFT, AMC and AMA as anthropometric indices showed no significant alteration, which showed no significant change in nutritional status. We found no significant improvement or ingravescence of subjective symptoms in the daily lives of the HD patients. In comparison to HF dialyzers, SHF dialyzers provided a significantly higher reduction rate in a larger middle-size molecule with no decrease in a serum concentration of a large-size molecule preserving common health conditions in patients undergoing maintenance HD." @default.
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• W2954859097 date "2019-07-01" @default.
• W2954859097 modified "2023-09-27" @default.
• W2954859097 title "MON-128 COMPARISON OF LABORATORY AND CLINICL FEATURES BETWEEN HIGH- AND SUPERHIGH-FLUX MEMBRAES IN PATIENTS UNDERGOIN MAINTENANCE HEMODIALYSIS" @default.
• W2954859097 doi "https://doi.org/10.1016/j.ekir.2019.05.918" @default.
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