Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954864461> ?p ?o ?g. }
- W2954864461 endingPage "487" @default.
- W2954864461 startingPage "475" @default.
- W2954864461 abstract "ProBiotic-4 is a probiotic preparation composed of Bifidobacterium lactis, Lactobacillus casei, Bifidobacterium bifidum, and Lactobacillus acidophilus. This study aims to investigate the effects of ProBiotic-4 on the microbiota–gut–brain axis and cognitive deficits, and to explore the underlying molecular mechanism using senescence-accelerated mouse prone 8 (SAMP8) mice. ProBiotic-4 was orally administered to 9-month-old SAMP8 mice for 12 weeks. We observed that ProBiotic-4 significantly improved the memory deficits, cerebral neuronal and synaptic injuries, glial activation, and microbiota composition in the feces and brains of aged SAMP8 mice. ProBiotic-4 substantially attenuated aging-related disruption of the intestinal barrier and blood–brain barrier, decreased interleukin-6 and tumor necrosis factor-α at both mRNA and protein levels, reduced plasma and cerebral lipopolysaccharide (LPS) concentration, toll-like receptor 4 (TLR4) expression, and nuclear factor-κB (NF-κB) nuclear translocation in the brain. In addition, not only did ProBiotic-4 significantly decreased the levels of γ-H2AX, 8-hydroxydesoxyguanosine, and retinoic-acid-inducible gene-I (RIG-I), it also abrogated RIG-I multimerization in the brain. These findings suggest that targeting gut microbiota with probiotics may have a therapeutic potential for the deficits of the microbiota–gut–brain axis and cognitive function in aging, and that its mechanism is associated with inhibition of both TLR4-and RIG-I-mediated NF-κB signaling pathway and inflammatory responses." @default.
- W2954864461 created "2019-07-12" @default.
- W2954864461 creator A5016645265 @default.
- W2954864461 creator A5052484642 @default.
- W2954864461 creator A5052957645 @default.
- W2954864461 creator A5068819007 @default.
- W2954864461 creator A5085696635 @default.
- W2954864461 date "2020-03-01" @default.
- W2954864461 modified "2023-10-14" @default.
- W2954864461 title "Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice" @default.
- W2954864461 cites W1524159193 @default.
- W2954864461 cites W1647551795 @default.
- W2954864461 cites W1964314628 @default.
- W2954864461 cites W1987184081 @default.
- W2954864461 cites W2005258869 @default.
- W2954864461 cites W2005911385 @default.
- W2954864461 cites W2024042582 @default.
- W2954864461 cites W2028807913 @default.
- W2954864461 cites W2032689615 @default.
- W2954864461 cites W2048830729 @default.
- W2954864461 cites W2055857680 @default.
- W2954864461 cites W2071415161 @default.
- W2954864461 cites W2088038548 @default.
- W2954864461 cites W2089510415 @default.
- W2954864461 cites W2113300154 @default.
- W2954864461 cites W2116802655 @default.
- W2954864461 cites W2116846792 @default.
- W2954864461 cites W2131536322 @default.
- W2954864461 cites W2151043086 @default.
- W2954864461 cites W2155152361 @default.
- W2954864461 cites W2159122349 @default.
- W2954864461 cites W2161062702 @default.
- W2954864461 cites W2192080449 @default.
- W2954864461 cites W2345500865 @default.
- W2954864461 cites W2404883061 @default.
- W2954864461 cites W2441277973 @default.
- W2954864461 cites W2476848306 @default.
- W2954864461 cites W2507288765 @default.
- W2954864461 cites W2508939482 @default.
- W2954864461 cites W2549210709 @default.
- W2954864461 cites W2558599134 @default.
- W2954864461 cites W2576399021 @default.
- W2954864461 cites W2588681363 @default.
- W2954864461 cites W2612886875 @default.
- W2954864461 cites W2692314407 @default.
- W2954864461 cites W2759183613 @default.
- W2954864461 cites W2762408398 @default.
- W2954864461 cites W2765279273 @default.
- W2954864461 cites W2774174162 @default.
- W2954864461 cites W2774851697 @default.
- W2954864461 cites W2789114236 @default.
- W2954864461 cites W2789765536 @default.
- W2954864461 cites W2789850150 @default.
- W2954864461 cites W2802041481 @default.
- W2954864461 cites W2802588821 @default.
- W2954864461 cites W2803442844 @default.
- W2954864461 cites W2810492961 @default.
- W2954864461 cites W2883537236 @default.
- W2954864461 cites W2887914699 @default.
- W2954864461 cites W2888837110 @default.
- W2954864461 cites W2892324900 @default.
- W2954864461 cites W2904465109 @default.
- W2954864461 cites W2908535595 @default.
- W2954864461 cites W2953191221 @default.
- W2954864461 doi "https://doi.org/10.1016/j.apsb.2019.07.001" @default.
- W2954864461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7049608" @default.
- W2954864461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32140393" @default.
- W2954864461 hasPublicationYear "2020" @default.
- W2954864461 type Work @default.
- W2954864461 sameAs 2954864461 @default.
- W2954864461 citedByCount "161" @default.
- W2954864461 countsByYear W29548644612020 @default.
- W2954864461 countsByYear W29548644612021 @default.
- W2954864461 countsByYear W29548644612022 @default.
- W2954864461 countsByYear W29548644612023 @default.
- W2954864461 crossrefType "journal-article" @default.
- W2954864461 hasAuthorship W2954864461A5016645265 @default.
- W2954864461 hasAuthorship W2954864461A5052484642 @default.
- W2954864461 hasAuthorship W2954864461A5052957645 @default.
- W2954864461 hasAuthorship W2954864461A5068819007 @default.
- W2954864461 hasAuthorship W2954864461A5085696635 @default.
- W2954864461 hasBestOaLocation W29548644611 @default.
- W2954864461 hasConcept C100544194 @default.
- W2954864461 hasConcept C177857423 @default.
- W2954864461 hasConcept C17991360 @default.
- W2954864461 hasConcept C203014093 @default.
- W2954864461 hasConcept C2776070231 @default.
- W2954864461 hasConcept C2776662696 @default.
- W2954864461 hasConcept C2776914184 @default.
- W2954864461 hasConcept C2777221637 @default.
- W2954864461 hasConcept C2778641530 @default.
- W2954864461 hasConcept C2778754761 @default.
- W2954864461 hasConcept C2780206646 @default.
- W2954864461 hasConcept C2780255968 @default.
- W2954864461 hasConcept C2780305828 @default.
- W2954864461 hasConcept C523546767 @default.
- W2954864461 hasConcept C539455810 @default.
- W2954864461 hasConcept C54355233 @default.