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- W2954877882 abstract "Aim: Poly(ε-caprolactone) lipid-core nanocapsules (LNCs) are efficient drug carriers and drug-free LNCs display therapeutic effects, inhibiting tumor growth and neutrophil activities. Herein, we investigated the direct actions of LNCs on human immune cells, to guide their therapeutic application. Materials & methods: LNC’s uptake, cytokine release, cell migration, proliferation and intracellular pathways under inflammatory stimulation were investigated. Results & conclusion: LNCs quickly penetrated leukocytes without cytotoxicity; inhibited mitogen-induced lymphocyte proliferation, cytokine release and leukocyte migration under inflammatory stimulation, which were associated with inhibition of the MAP kinase pathway and intracellular calcium influx. Hence, we showed LNCs as a down-regulatory agent on immune cells, suggesting that either the particles themselves or their application as a drug carrier can halt non-desired inflammatory processes." @default.
- W2954877882 created "2019-07-12" @default.
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- W2954877882 date "2019-06-01" @default.
- W2954877882 modified "2023-10-01" @default.
- W2954877882 title "Direct effects of poly(ε-caprolactone) lipid-core nanocapsules on human immune cells" @default.
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- W2954877882 doi "https://doi.org/10.2217/nnm-2018-0484" @default.
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