FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954889346> ?p ?o ?g. }

• W2954889346 endingPage "101042831986072" @default.
• W2954889346 startingPage "101042831986072" @default.
• W2954889346 abstract "Colon cancer represents one of the most common cancers in the world. Despite improved treatment, mortality remains high. In order to improve the assessment of prognosis for colon cancer patients, identifying new prognostic markers remains necessary. We analyzed preoperative serum samples from 148 colon cancer patients surgically treated at Helsinki University Hospital from 1998 through 2002 using a multiplex proximity extension assay (Oncology II panel, Olink Bioscience, Uppsala, Sweden), a panel constituting 92 immunological and oncological markers. We performed univariate and multivariate analyses on these patients and calculated the disease-specific survival among patients using the log-rank test for Kaplan–Meier estimates. In the univariate survival analysis of 92 biomarkers, 26 resulted in p < 0.1. Among these, eight biomarkers emerged as statistically significant (p < 0.05). Patients with low levels of kallikrein 13 had a poor prognosis. Moreover, patients with high levels of amphiregulin, carcinoembryonic antigen-related adhesion molecule 5, interleukin 6, mucin 16, syndecan 1, transforming growth factor alpha, and vimentin also had a poor prognosis. In the multivariate analysis, kallikrein 13 and mucin 16 emerged as independent prognostic markers. The role of kallikrein 13, a member of the serine protease kallikrein biomarker family, in tumorigenesis remains unclear. Mucin 16 is also known as carbohydrate antigen 125, a well-known ovarian cancer biomarker. Patients with low levels of kallikrein 13 (hazard ratio: 0.36; 95% confidence interval: 0.14–0.92; p = 0.033) and high levels of mucin 16 (hazard ratio: 3.15; 95% confidence interval: 1.68–5.93; p < 0.005) had a poor prognosis. Mucin 16 and kallikrein 13 represent independent prognostic markers for colon cancer. Furthermore, the clinical utility of mucin 16 and kallikrein 13 serum tests warrants additional investigation." @default.
• W2954889346 created "2019-07-12" @default.
• W2954889346 creator A5035651238 @default.
• W2954889346 creator A5045989882 @default.
• W2954889346 creator A5055369999 @default.
• W2954889346 creator A5077860140 @default.
• W2954889346 creator A5080445150 @default.
• W2954889346 date "2019-07-01" @default.
• W2954889346 modified "2023-10-15" @default.
• W2954889346 title "Mucin 16 and kallikrein 13 as potential prognostic factors in colon cancer: Results of an oncological 92-multiplex immunoassay" @default.
• W2954889346 cites W1513037102 @default.
• W2954889346 cites W1671238747 @default.
• W2954889346 cites W1934094702 @default.
• W2954889346 cites W1966205227 @default.
• W2954889346 cites W1972462022 @default.
• W2954889346 cites W2010084870 @default.
• W2954889346 cites W2028909855 @default.
• W2954889346 cites W2036147404 @default.
• W2954889346 cites W2037412915 @default.
• W2954889346 cites W2041711980 @default.
• W2954889346 cites W2051278903 @default.
• W2954889346 cites W2092956762 @default.
• W2954889346 cites W2102948567 @default.
• W2954889346 cites W2153198430 @default.
• W2954889346 cites W2284843308 @default.
• W2954889346 cites W2309587111 @default.
• W2954889346 cites W2514812855 @default.
• W2954889346 cites W252266348 @default.
• W2954889346 cites W2555141263 @default.
• W2954889346 cites W2602415901 @default.
• W2954889346 cites W2611983942 @default.
• W2954889346 cites W2783198920 @default.
• W2954889346 cites W2793871274 @default.
• W2954889346 cites W2796075965 @default.
• W2954889346 cites W2889646458 @default.
• W2954889346 cites W2912891382 @default.
• W2954889346 cites W4382585727 @default.
• W2954889346 doi "https://doi.org/10.1177/1010428319860728" @default.
• W2954889346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31264534" @default.
• W2954889346 hasPublicationYear "2019" @default.
• W2954889346 type Work @default.
• W2954889346 sameAs 2954889346 @default.
• W2954889346 citedByCount "10" @default.
• W2954889346 countsByYear W29548893462020 @default.
• W2954889346 countsByYear W29548893462021 @default.
• W2954889346 countsByYear W29548893462023 @default.
• W2954889346 crossrefType "journal-article" @default.
• W2954889346 hasAuthorship W2954889346A5035651238 @default.
• W2954889346 hasAuthorship W2954889346A5045989882 @default.
• W2954889346 hasAuthorship W2954889346A5055369999 @default.
• W2954889346 hasAuthorship W2954889346A5077860140 @default.
• W2954889346 hasAuthorship W2954889346A5080445150 @default.
• W2954889346 hasBestOaLocation W29548893461 @default.
• W2954889346 hasConcept C121608353 @default.
• W2954889346 hasConcept C126322002 @default.
• W2954889346 hasConcept C142724271 @default.
• W2954889346 hasConcept C143998085 @default.
• W2954889346 hasConcept C144301174 @default.
• W2954889346 hasConcept C181199279 @default.
• W2954889346 hasConcept C207103383 @default.
• W2954889346 hasConcept C2777387746 @default.
• W2954889346 hasConcept C2781197716 @default.
• W2954889346 hasConcept C38180746 @default.
• W2954889346 hasConcept C44249647 @default.
• W2954889346 hasConcept C526805850 @default.
• W2954889346 hasConcept C52853521 @default.
• W2954889346 hasConcept C55493867 @default.
• W2954889346 hasConcept C71924100 @default.
• W2954889346 hasConcept C86803240 @default.
• W2954889346 hasConcept C90924648 @default.
• W2954889346 hasConceptScore W2954889346C121608353 @default.
• W2954889346 hasConceptScore W2954889346C126322002 @default.
• W2954889346 hasConceptScore W2954889346C142724271 @default.
• W2954889346 hasConceptScore W2954889346C143998085 @default.
• W2954889346 hasConceptScore W2954889346C144301174 @default.
• W2954889346 hasConceptScore W2954889346C181199279 @default.
• W2954889346 hasConceptScore W2954889346C207103383 @default.
• W2954889346 hasConceptScore W2954889346C2777387746 @default.
• W2954889346 hasConceptScore W2954889346C2781197716 @default.
• W2954889346 hasConceptScore W2954889346C38180746 @default.
• W2954889346 hasConceptScore W2954889346C44249647 @default.
• W2954889346 hasConceptScore W2954889346C526805850 @default.
• W2954889346 hasConceptScore W2954889346C52853521 @default.
• W2954889346 hasConceptScore W2954889346C55493867 @default.
• W2954889346 hasConceptScore W2954889346C71924100 @default.
• W2954889346 hasConceptScore W2954889346C86803240 @default.
• W2954889346 hasConceptScore W2954889346C90924648 @default.
• W2954889346 hasFunder F4320310086 @default.
• W2954889346 hasFunder F4320311816 @default.
• W2954889346 hasFunder F4320323760 @default.
• W2954889346 hasIssue "7" @default.
• W2954889346 hasLocation W29548893461 @default.
• W2954889346 hasLocation W29548893462 @default.
• W2954889346 hasLocation W29548893463 @default.
• W2954889346 hasOpenAccess W2954889346 @default.
• W2954889346 hasPrimaryLocation W29548893461 @default.
• W2954889346 hasRelatedWork W1533674099 @default.
• W2954889346 hasRelatedWork W185860436 @default.

• next