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- W2954952600 abstract "The liver oil from C. monstrosa (rat fish) has traditionally been used as a natural remedy in the area around Skagerrak, since it is believed to have a wound healing and analgesic effects. On its back the rat fish carries a vigorous venom spine connected to glandular cells, which secrets toxins. A previous study shows that extract from the liver and venom glands had a cytotoxic activity on A. nauplii and antibacterial activity on S. aureus. The aim of this study was therefore to investigate the bioactivity of extracted compounds and to make a second step towards identifying there character and structure. Bioactive substances where isolated, purified and further examined with bioactivity assays, LC-MSMS and NMR. Bacteria assays showed that extracts from the liver and venom glands had antibacterial activity on both S. aureus and E. coli at the concentration 7 µg/ml, and that an isolated pure substance with the mass 479 had an antibacterial activity at the concentration 40 µM. This substance is therefore an interesting antibiotic candidate. A suggested structure of the substance 479 was assembled using NMR and LC-MSMS. An Artemia assay showed that that extracts from the liver and venom glands had a cytotoxic activity at the concentration 0.2 mg/ml. The effect was lethal at the concentration 2 mg/ml and paralytic at 0.2 mg/ml. Subparts of a substance with the mass 637 were also assembled using NMR and LC-MSMS. This substance might be partly responsible for the cytotoxic activity seen in the extracts from the liver and venom glands. The antibacterial and cytotoxic compounds found in the liver and venom extracts of the fish may form part of the solution to the search for new biocides and analgesic drugs. Therefore, the examination of these need to continue until they are completely identified and described. (Less)" @default.
- W2954952600 created "2019-07-12" @default.
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- W2954952600 date "2019-01-01" @default.
- W2954952600 modified "2023-09-27" @default.
- W2954952600 title "Examination, Identification and Characterization of Bioactive Compounds Found in the Liver and Venom sac of Chimaera monstrosa" @default.
- W2954952600 hasPublicationYear "2019" @default.
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