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• W2954957264 abstract "Background Rosacea is a chronic disease that is characterized by facial skin inflammation and vascular abnormality. Vascular endothelial growth factor (VEGF) is a potent mediator of vascular permeability and inflammation that might play a role in the pathogenesis of rosacea. Objective This study aimed to determine the association between VEGF gene polymorphisms and rosacea. Methods A case-control study design was used to compare 100 patients with rosacea and 100 age- and gender-matched control subjects in terms of VEGF polymorphisms based on polymerase chain reaction and the serum level of VEGF and VEGF receptors based on enzyme-linked immunosorbent assay. Results Heterozygous and homozygous +405C/G polymorphism of the VEGF gene was observed to increase the risk of rosacea 1.7-fold (95% confidence interval 1.2-4.2) and 2.3-fold (95% confidence interval 1.2-4.2), respectively. There was a significant positive correlation between the severity of rosacea and +405C/G polymorphism of the VEGF gene in patients with erythematotelangiectatic rosacea. Limitations Serum VEGF and VEGF receptor levels were measured in the limited number of patients. Conclusion The present findings indicate that +405C/G polymorphism of the VEGF gene increases the risk of rosacea. Rosacea is a chronic disease that is characterized by facial skin inflammation and vascular abnormality. Vascular endothelial growth factor (VEGF) is a potent mediator of vascular permeability and inflammation that might play a role in the pathogenesis of rosacea. This study aimed to determine the association between VEGF gene polymorphisms and rosacea. A case-control study design was used to compare 100 patients with rosacea and 100 age- and gender-matched control subjects in terms of VEGF polymorphisms based on polymerase chain reaction and the serum level of VEGF and VEGF receptors based on enzyme-linked immunosorbent assay. Heterozygous and homozygous +405C/G polymorphism of the VEGF gene was observed to increase the risk of rosacea 1.7-fold (95% confidence interval 1.2-4.2) and 2.3-fold (95% confidence interval 1.2-4.2), respectively. There was a significant positive correlation between the severity of rosacea and +405C/G polymorphism of the VEGF gene in patients with erythematotelangiectatic rosacea. Serum VEGF and VEGF receptor levels were measured in the limited number of patients. The present findings indicate that +405C/G polymorphism of the VEGF gene increases the risk of rosacea." @default.
• W2954957264 created "2019-07-12" @default.
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• W2954957264 date "2019-08-01" @default.
• W2954957264 modified "2023-09-26" @default.
• W2954957264 title "Vascular endothelial growth factor gene polymorphisms in patients with rosacea: A case-control study" @default.
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• W2954957264 doi "https://doi.org/10.1016/j.jaad.2019.03.055" @default.
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