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- W2954958768 abstract "Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer clusters or super-enhancers. So far, such domains have been defined through clustering of enhancers in linear genome maps rather than in three-dimensional (3D) space. Furthermore, their target genes are often unknown. We have created promoter capture Hi-C maps in human pancreatic islets. This linked diabetes-associated enhancers to their target genes, often located hundreds of kilobases away. It also revealed >1,300 groups of islet enhancers, super-enhancers and active promoters that form 3D hubs, some of which show coordinated glucose-dependent activity. We demonstrate that genetic variation in hubs impacts insulin secretion heritability, and show that hub annotations can be used for polygenic scores that predict T2D risk driven by islet regulatory variants. Human islet 3D chromatin architecture, therefore, provides a framework for interpretation of T2D genome-wide association study (GWAS) signals." @default.
- W2954958768 created "2019-07-12" @default.
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- W2954958768 date "2019-06-28" @default.
- W2954958768 modified "2023-10-18" @default.
- W2954958768 title "Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes" @default.
- W2954958768 cites W1844405070 @default.
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- W2954958768 cites W1978824708 @default.
- W2954958768 cites W1983100478 @default.
- W2954958768 cites W1996676082 @default.
- W2954958768 cites W2004966039 @default.
- W2954958768 cites W2014744835 @default.
- W2954958768 cites W2025665777 @default.
- W2954958768 cites W2027792163 @default.
- W2954958768 cites W2036897871 @default.
- W2954958768 cites W2056198580 @default.
- W2954958768 cites W2068143018 @default.
- W2954958768 cites W2070021921 @default.
- W2954958768 cites W2074656730 @default.
- W2954958768 cites W2079407198 @default.
- W2954958768 cites W2082704080 @default.
- W2954958768 cites W2082793267 @default.
- W2954958768 cites W2087036932 @default.
- W2954958768 cites W2092043122 @default.
- W2954958768 cites W2098318348 @default.
- W2954958768 cites W2098679983 @default.
- W2954958768 cites W2102904139 @default.
- W2954958768 cites W2103393606 @default.
- W2954958768 cites W2108234281 @default.
- W2954958768 cites W2110048796 @default.
- W2954958768 cites W2116261028 @default.
- W2954958768 cites W2117757143 @default.
- W2954958768 cites W2119180969 @default.
- W2954958768 cites W2134907628 @default.
- W2954958768 cites W2139852278 @default.
- W2954958768 cites W2148212953 @default.
- W2954958768 cites W2153399820 @default.
- W2954958768 cites W2153856160 @default.
- W2954958768 cites W2153860431 @default.
- W2954958768 cites W2160856280 @default.
- W2954958768 cites W2161212572 @default.
- W2954958768 cites W2169004323 @default.
- W2954958768 cites W2170551349 @default.
- W2954958768 cites W2171678230 @default.
- W2954958768 cites W2171808845 @default.
- W2954958768 cites W2177538943 @default.
- W2954958768 cites W2186803051 @default.
- W2954958768 cites W2194368213 @default.
- W2954958768 cites W2259938310 @default.
- W2954958768 cites W2313488052 @default.
- W2954958768 cites W2345356016 @default.
- W2954958768 cites W2413234541 @default.
- W2954958768 cites W2461793432 @default.
- W2954958768 cites W2466943507 @default.
- W2954958768 cites W2511515754 @default.
- W2954958768 cites W2516036129 @default.
- W2954958768 cites W2528021625 @default.
- W2954958768 cites W2534494590 @default.
- W2954958768 cites W2553838260 @default.
- W2954958768 cites W2557097554 @default.