FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954976003> ?p ?o ?g. }

• W2954976003 abstract "Introduction: Ovarian cancer is a heterogeneous disease; each histotype has distinct molecular origins, risk factors and outcomes. While it is well established that ovarian cancer has a familial risk component, the familiality of ovarian cancer histotypes has not been well described. The Utah Population Database (UPDB) captures over 10 million individuals, including more than 5 million with a minimum of three generations of genealogy data. By linking records from the UPDB to the Utah Cancer Registry (UCR) and other statewide data sources, we sought to describe the familiality of ovarian cancer histotypes. Methods: Our study includes all ovarian cancer cases in the UPDB and leverages clinical data reported to UCR for the case histotypes. Cases were matched to controls on age, birth cohort and at least three generations of UPDB data versus not. We quantified familiality by comparing the odds of ovarian cancer occurrence among family members of cases to the odds of ovarian cancer among family members of matched controls. We calculated odds ratios for first-degree relatives, second-degree relatives, and first cousins. Results: As of September 2018, the UPDB included 3,989 ovarian cancer cases. We observed an increased risk of epithelial ovarian cancer among first-degree relatives (OR=1.62, 95%CI=1.36-1.93), second-degree relatives (OR=1.53, 95%CI=1.34-1.74), and first cousins (OR=1.38, 95%CI=1.26-1.53) of ovarian cancer cases. When we analyzed epithelial ovarian cancers by histotype, familiality was most evident for high-grade serous, mucinous, and unclassified cancers. For example, we observed a 1.62-fold increased odds (95%CI=1.14-2.29) of high-grade serous ovarian cancer among the first-degree relatives of high-grade serous cases, and a 5.59-fold increased odds (95%CI=2.09-14.92) of mucinous ovarian cancer among first-degree relatives of mucinous ovarian cancer cases. Familiality patterns were less clear among endometrioid and clear cell cases. Conclusions: The UPDB has the potential to contribute greatly to family-based studies of the genetics of ovarian cancer histotypes. Despite the possible variations in quality of histotype data across generations, preliminary results suggest some histotypes may be particularly familial and good candidates for gene mapping studies. Work is ongoing to refine the histotype assignments for cases by performing pathology review using the 2014 World Health Organization guidelines. Analyses are also in progress to stratify analyses by BRCA mutation status, and to consider the potential for shared familiality across ovarian cancer histotypes and with cancers at other sites. Citation Format: Mollie E. Barnard, Nicola J. Camp, Jennifer A. Doherty. Familiality of ovarian cancer histotypes in the Utah Population Database [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 4174." @default.
• W2954976003 created "2019-07-12" @default.
• W2954976003 creator A5064382326 @default.
• W2954976003 creator A5070882400 @default.
• W2954976003 creator A5075544315 @default.
• W2954976003 date "2019-07-01" @default.
• W2954976003 modified "2023-09-23" @default.
• W2954976003 title "Abstract 4174: Familiality of ovarian cancer histotypes in the Utah Population Database" @default.
• W2954976003 doi "https://doi.org/10.1158/1538-7445.sabcs18-4174" @default.
• W2954976003 hasPublicationYear "2019" @default.
• W2954976003 type Work @default.
• W2954976003 sameAs 2954976003 @default.
• W2954976003 citedByCount "0" @default.
• W2954976003 crossrefType "proceedings-article" @default.
• W2954976003 hasAuthorship W2954976003A5064382326 @default.
• W2954976003 hasAuthorship W2954976003A5070882400 @default.
• W2954976003 hasAuthorship W2954976003A5075544315 @default.
• W2954976003 hasConcept C121608353 @default.
• W2954976003 hasConcept C126322002 @default.
• W2954976003 hasConcept C143998085 @default.
• W2954976003 hasConcept C150173356 @default.
• W2954976003 hasConcept C156957248 @default.
• W2954976003 hasConcept C2778527826 @default.
• W2954976003 hasConcept C2780427987 @default.
• W2954976003 hasConcept C2781179581 @default.
• W2954976003 hasConcept C2908647359 @default.
• W2954976003 hasConcept C29456083 @default.
• W2954976003 hasConcept C71924100 @default.
• W2954976003 hasConcept C72563966 @default.
• W2954976003 hasConcept C99454951 @default.
• W2954976003 hasConceptScore W2954976003C121608353 @default.
• W2954976003 hasConceptScore W2954976003C126322002 @default.
• W2954976003 hasConceptScore W2954976003C143998085 @default.
• W2954976003 hasConceptScore W2954976003C150173356 @default.
• W2954976003 hasConceptScore W2954976003C156957248 @default.
• W2954976003 hasConceptScore W2954976003C2778527826 @default.
• W2954976003 hasConceptScore W2954976003C2780427987 @default.
• W2954976003 hasConceptScore W2954976003C2781179581 @default.
• W2954976003 hasConceptScore W2954976003C2908647359 @default.
• W2954976003 hasConceptScore W2954976003C29456083 @default.
• W2954976003 hasConceptScore W2954976003C71924100 @default.
• W2954976003 hasConceptScore W2954976003C72563966 @default.
• W2954976003 hasConceptScore W2954976003C99454951 @default.
• W2954976003 hasLocation W29549760031 @default.
• W2954976003 hasOpenAccess W2954976003 @default.
• W2954976003 hasPrimaryLocation W29549760031 @default.
• W2954976003 hasRelatedWork W1967147743 @default.
• W2954976003 hasRelatedWork W1983173207 @default.
• W2954976003 hasRelatedWork W2001139812 @default.
• W2954976003 hasRelatedWork W2031749863 @default.
• W2954976003 hasRelatedWork W2034016156 @default.
• W2954976003 hasRelatedWork W2123554362 @default.
• W2954976003 hasRelatedWork W2164479761 @default.
• W2954976003 hasRelatedWork W2170958906 @default.
• W2954976003 hasRelatedWork W2395438462 @default.
• W2954976003 hasRelatedWork W2417080654 @default.
• W2954976003 hasRelatedWork W2430846728 @default.
• W2954976003 hasRelatedWork W2533650779 @default.
• W2954976003 hasRelatedWork W2592924849 @default.
• W2954976003 hasRelatedWork W2785381890 @default.
• W2954976003 hasRelatedWork W2895692674 @default.
• W2954976003 hasRelatedWork W2946245940 @default.
• W2954976003 hasRelatedWork W3007602973 @default.
• W2954976003 hasRelatedWork W3008923826 @default.
• W2954976003 hasRelatedWork W3176634852 @default.
• W2954976003 hasRelatedWork W963663280 @default.
• W2954976003 isParatext "false" @default.
• W2954976003 isRetracted "false" @default.
• W2954976003 magId "2954976003" @default.
• W2954976003 workType "article" @default.