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• W2954976094 abstract "The present study examined the protective effects of water chloride (Cl−) towards nitrite toxicity in Atlantic salmon parr during 84-day long nitrite exposure. Effects on growth, histology, blood indices and gene expression were studied at a fixed nominal Cl− concentration of 200 mg/L and at several water nitrite concentrations (0, 0.5, 2, 5 and 10 mg/L NO2−–N). The specific growth rate was significantly reduced during the first three weeks at a Cl:NO2−–N ratio of 21:1, suggesting the activation of coping mechanisms at the later stages of the experiment. No significant effect of nitrite on gill histology and mortality was found. Nitrite accumulated in plasma; however, a Cl:NO2−–N ratio of 104:1 or higher prevented nitrite entry. The concentration of NO2−–N in plasma was significantly reduced at the end of the study, supporting the hypothesis of coping mechanisms. Cystic fibrosis transmembrane conductance regulator (cftr)-1 showed a significant up-regulation at highest nitrite concentration on day 22, and in three of the highest exposure groups at the end of the experiment. Our findings suggest that a Cl:NO2−–N ratio above 104:1 should be maintained through episodes of nitrite accumulation in water during the production of Atlantic salmon parr." @default.
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• W2954976094 date "2019-07-01" @default.
• W2954976094 modified "2023-09-25" @default.
• W2954976094 title "Effects of chronic sub‐lethal nitrite exposure at high water chloride concentration on Atlantic salmon ( <i>Salmo salar,</i> Linnaeus 1758) parr" @default.
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• W2954976094 doi "https://doi.org/10.1111/are.14226" @default.
• W2954976094 hasPublicationYear "2019" @default.
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