FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954977219> ?p ?o ?g. }

• W2954977219 endingPage "e0217472" @default.
• W2954977219 startingPage "e0217472" @default.
• W2954977219 abstract "The Ischemic Stroke System is a novel device designed to deliver stimulation to the sphenopalatine ganglion(SPG).The SPG sends parasympathetic innervations to the anterior cerebral circulation. In rat stroke models, SPG stimulation results in increased cerebral blood flow, reduced infarct volume, protects the blood brain barrier, and improved neurological outcome. We present here the results of a prospective, multinational, single-arm, feasibility study designed to assess the safety, tolerability, and potential benefit of SPG stimulation inpatients with acute ischemic stroke(AIS).Patients with anterior AIS, baseline NIHSS 7-20 and ability to initiate treatment within 24h from stroke onset, were implanted and treated with the SPG stimulation. Patients were followed up for 90 days. Effect was assessed by comparing the patient outcome to a matched population from the NINDS rt-PA trial placebo patients.Ninety-eight patients were enrolled (mean age 57years, mean baseline NIHSS 12 and mean treatment time from stroke onset 19h). The observed mortality rate(12.2%), serious adverse events (SAE)incidence(23.5%) and nature of SAE were within the expected range for the population. The modified intention to treat cohort consisted of 84 patients who were compared to matched patients from the NINDS placebo arm. Patients treated with SPG stimulation had an average mRS lower by 0.76 than the historical controls(CMH test p = 0.001).The implantation procedure and the SPG stimulation, initiated within 24hr from stroke onset, are feasible, safe, and tolerable. The results call for a follow-up randomized trial (funded by BrainsGate; clinicaltrials.gov number, NCT03733236)." @default.
• W2954977219 created "2019-07-12" @default.
• W2954977219 creator A5010657934 @default.
• W2954977219 creator A5013719819 @default.
• W2954977219 creator A5020087029 @default.
• W2954977219 creator A5026262205 @default.
• W2954977219 creator A5028464878 @default.
• W2954977219 creator A5029575185 @default.
• W2954977219 creator A5043283447 @default.
• W2954977219 creator A5049732262 @default.
• W2954977219 creator A5052759316 @default.
• W2954977219 creator A5055320315 @default.
• W2954977219 creator A5066093005 @default.
• W2954977219 creator A5078146231 @default.
• W2954977219 creator A5084315186 @default.
• W2954977219 creator A5085115496 @default.
• W2954977219 date "2019-07-03" @default.
• W2954977219 modified "2023-09-25" @default.
• W2954977219 title "Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). A single-arm feasibility study evaluating the safety and potential benefit of the Ischemic Stroke System for treatment of acute ischemic stroke" @default.
• W2954977219 cites W1963611672 @default.
• W2954977219 cites W1963624288 @default.
• W2954977219 cites W1996689955 @default.
• W2954977219 cites W1996802760 @default.
• W2954977219 cites W1999734671 @default.
• W2954977219 cites W2019622055 @default.
• W2954977219 cites W2027739927 @default.
• W2954977219 cites W2050246367 @default.
• W2954977219 cites W2061570300 @default.
• W2954977219 cites W2080504768 @default.
• W2954977219 cites W2093072754 @default.
• W2954977219 cites W2107831538 @default.
• W2954977219 cites W2169317132 @default.
• W2954977219 cites W2171058244 @default.
• W2954977219 cites W2171165037 @default.
• W2954977219 cites W2292308933 @default.
• W2954977219 cites W2767776410 @default.
• W2954977219 cites W2787867590 @default.
• W2954977219 cites W2888906063 @default.
• W2954977219 cites W2890910536 @default.
• W2954977219 cites W4242649591 @default.
• W2954977219 cites W4255683973 @default.
• W2954977219 cites W4307833091 @default.
• W2954977219 cites W4362062050 @default.
• W2954977219 doi "https://doi.org/10.1371/journal.pone.0217472" @default.
• W2954977219 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6609146" @default.
• W2954977219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31269025" @default.
• W2954977219 hasPublicationYear "2019" @default.
• W2954977219 type Work @default.
• W2954977219 sameAs 2954977219 @default.
• W2954977219 citedByCount "3" @default.
• W2954977219 countsByYear W29549772192019 @default.
• W2954977219 countsByYear W29549772192021 @default.
• W2954977219 countsByYear W29549772192023 @default.
• W2954977219 crossrefType "journal-article" @default.
• W2954977219 hasAuthorship W2954977219A5010657934 @default.
• W2954977219 hasAuthorship W2954977219A5013719819 @default.
• W2954977219 hasAuthorship W2954977219A5020087029 @default.
• W2954977219 hasAuthorship W2954977219A5026262205 @default.
• W2954977219 hasAuthorship W2954977219A5028464878 @default.
• W2954977219 hasAuthorship W2954977219A5029575185 @default.
• W2954977219 hasAuthorship W2954977219A5043283447 @default.
• W2954977219 hasAuthorship W2954977219A5049732262 @default.
• W2954977219 hasAuthorship W2954977219A5052759316 @default.
• W2954977219 hasAuthorship W2954977219A5055320315 @default.
• W2954977219 hasAuthorship W2954977219A5066093005 @default.
• W2954977219 hasAuthorship W2954977219A5078146231 @default.
• W2954977219 hasAuthorship W2954977219A5084315186 @default.
• W2954977219 hasAuthorship W2954977219A5085115496 @default.
• W2954977219 hasBestOaLocation W29549772191 @default.
• W2954977219 hasConcept C126322002 @default.
• W2954977219 hasConcept C127413603 @default.
• W2954977219 hasConcept C141071460 @default.
• W2954977219 hasConcept C142724271 @default.
• W2954977219 hasConcept C157767197 @default.
• W2954977219 hasConcept C168563851 @default.
• W2954977219 hasConcept C188816634 @default.
• W2954977219 hasConcept C197934379 @default.
• W2954977219 hasConcept C204787440 @default.
• W2954977219 hasConcept C27081682 @default.
• W2954977219 hasConcept C2778375690 @default.
• W2954977219 hasConcept C2780645631 @default.
• W2954977219 hasConcept C2908647359 @default.
• W2954977219 hasConcept C42219234 @default.
• W2954977219 hasConcept C71924100 @default.
• W2954977219 hasConcept C78519656 @default.
• W2954977219 hasConcept C99454951 @default.
• W2954977219 hasConceptScore W2954977219C126322002 @default.
• W2954977219 hasConceptScore W2954977219C127413603 @default.
• W2954977219 hasConceptScore W2954977219C141071460 @default.
• W2954977219 hasConceptScore W2954977219C142724271 @default.
• W2954977219 hasConceptScore W2954977219C157767197 @default.
• W2954977219 hasConceptScore W2954977219C168563851 @default.
• W2954977219 hasConceptScore W2954977219C188816634 @default.
• W2954977219 hasConceptScore W2954977219C197934379 @default.
• W2954977219 hasConceptScore W2954977219C204787440 @default.
• W2954977219 hasConceptScore W2954977219C27081682 @default.
• W2954977219 hasConceptScore W2954977219C2778375690 @default.
• W2954977219 hasConceptScore W2954977219C2780645631 @default.

• next