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- W2954980260 endingPage "3186" @default.
- W2954980260 startingPage "3186" @default.
- W2954980260 abstract "The repetitive telomeric DNA at chromosome ends is protected from unwanted repair by telomere-associated proteins, which form the shelterin complex in mammals. Recent works have provided new insights into the mechanisms of how human shelterin assembles and recruits telomerase to telomeres. Inhibition of telomerase activity and telomerase recruitment to chromosome ends is a promising target for anticancer therapy. Here, we summarize results of quantitative assessments and newly emerged structural information along with the status of the most promising approaches to telomerase inhibition in cancer cells. We focus on the mechanism of shelterin assembly and the mechanisms of how shelterin affects telomerase recruitment to telomeres, addressing the conceptual dilemma of how shelterin allows telomerase action and regulates other essential processes. We evaluate how the identified critical interactions of telomerase and shelterin might be elucidated in future research of new anticancer strategies." @default.
- W2954980260 created "2019-07-12" @default.
- W2954980260 creator A5005857471 @default.
- W2954980260 creator A5040646817 @default.
- W2954980260 creator A5066400671 @default.
- W2954980260 date "2019-06-28" @default.
- W2954980260 modified "2023-10-12" @default.
- W2954980260 title "Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest Point" @default.
- W2954980260 cites W1564838069 @default.
- W2954980260 cites W1927581912 @default.
- W2954980260 cites W1965130367 @default.
- W2954980260 cites W1966149222 @default.
- W2954980260 cites W1967358203 @default.
- W2954980260 cites W1968960900 @default.
- W2954980260 cites W1970657463 @default.
- W2954980260 cites W1978002329 @default.
- W2954980260 cites W1985910710 @default.
- W2954980260 cites W1998663807 @default.
- W2954980260 cites W1999334180 @default.
- W2954980260 cites W2000971601 @default.
- W2954980260 cites W2003446723 @default.
- W2954980260 cites W2004561527 @default.
- W2954980260 cites W2005830240 @default.
- W2954980260 cites W2006606296 @default.
- W2954980260 cites W2007550449 @default.
- W2954980260 cites W2011882274 @default.
- W2954980260 cites W2012398957 @default.
- W2954980260 cites W2014414194 @default.
- W2954980260 cites W2016672919 @default.
- W2954980260 cites W2026968102 @default.
- W2954980260 cites W2030209169 @default.
- W2954980260 cites W2030594866 @default.
- W2954980260 cites W2032407757 @default.
- W2954980260 cites W2043764151 @default.
- W2954980260 cites W2044126891 @default.
- W2954980260 cites W2047582165 @default.
- W2954980260 cites W2051990601 @default.
- W2954980260 cites W2053430492 @default.
- W2954980260 cites W2053620236 @default.
- W2954980260 cites W2056916397 @default.
- W2954980260 cites W2058159423 @default.
- W2954980260 cites W2062671651 @default.
- W2954980260 cites W2069013139 @default.
- W2954980260 cites W2069114225 @default.
- W2954980260 cites W2072744580 @default.
- W2954980260 cites W2073792387 @default.
- W2954980260 cites W2077951123 @default.
- W2954980260 cites W2078786713 @default.
- W2954980260 cites W2079538965 @default.
- W2954980260 cites W2080032853 @default.
- W2954980260 cites W2080776393 @default.
- W2954980260 cites W2087011288 @default.
- W2954980260 cites W2092226916 @default.
- W2954980260 cites W2100215079 @default.
- W2954980260 cites W2102490688 @default.
- W2954980260 cites W2103899181 @default.
- W2954980260 cites W2104500293 @default.
- W2954980260 cites W2106850855 @default.
- W2954980260 cites W2109975152 @default.
- W2954980260 cites W2112110490 @default.
- W2954980260 cites W2115346781 @default.
- W2954980260 cites W2116282320 @default.
- W2954980260 cites W2123105653 @default.
- W2954980260 cites W2125343208 @default.
- W2954980260 cites W2130471407 @default.
- W2954980260 cites W2136345741 @default.
- W2954980260 cites W2136350201 @default.
- W2954980260 cites W2140944222 @default.
- W2954980260 cites W2143795940 @default.
- W2954980260 cites W2145952889 @default.
- W2954980260 cites W2146200359 @default.
- W2954980260 cites W2146975106 @default.
- W2954980260 cites W2148013194 @default.
- W2954980260 cites W2148197898 @default.
- W2954980260 cites W2149471694 @default.
- W2954980260 cites W2151468358 @default.
- W2954980260 cites W2160185049 @default.
- W2954980260 cites W2161277166 @default.
- W2954980260 cites W2164412172 @default.
- W2954980260 cites W2164449007 @default.
- W2954980260 cites W2164580633 @default.
- W2954980260 cites W2194942599 @default.
- W2954980260 cites W2464740767 @default.
- W2954980260 cites W2465907273 @default.
- W2954980260 cites W2474358581 @default.
- W2954980260 cites W2509252213 @default.
- W2954980260 cites W2555177662 @default.
- W2954980260 cites W2568069475 @default.
- W2954980260 cites W2577431949 @default.
- W2954980260 cites W2590353570 @default.
- W2954980260 cites W2591294588 @default.
- W2954980260 cites W2595940044 @default.
- W2954980260 cites W2606373966 @default.
- W2954980260 cites W2612334799 @default.
- W2954980260 cites W2755174056 @default.
- W2954980260 cites W2765080185 @default.
- W2954980260 cites W2770413225 @default.
- W2954980260 cites W2786369468 @default.