FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955005592> ?p ?o ?g. }

• W2955005592 endingPage "3219" @default.
• W2955005592 startingPage "3219" @default.
• W2955005592 abstract "A number of signal transduction pathways are activated during Acute Kidney Injury (AKI). Of particular interest is the Salt Inducible Kinase (SIK) signaling network, and its effects on the Renal Proximal Tubule (RPT), one of the primary targets of injury in AKI. The SIK1 network is activated in the RPT following an increase in intracellular Na+ (Na+in), resulting in an increase in Na,K-ATPase activity, in addition to the phosphorylation of Class IIa Histone Deacetylases (HDACs). In addition, activated SIKs repress transcriptional regulation mediated by the interaction between cAMP Regulatory Element Binding Protein (CREB) and CREB Regulated Transcriptional Coactivators (CRTCs). Through their transcriptional effects, members of the SIK family regulate a number of metabolic processes, including such cellular processes regulated during AKI as fatty acid metabolism and mitochondrial biogenesis. SIKs are involved in regulating a number of other cellular events which occur during AKI, including apoptosis, the Epithelial to Mesenchymal Transition (EMT), and cell division. Recently, the different SIK kinase isoforms have emerged as promising drug targets, more than 20 new SIK2 inhibitors and activators having been identified by MALDI-TOF screening assays. Their implementation in the future should prove to be important in such renal disease states as AKI." @default.
• W2955005592 created "2019-07-12" @default.
• W2955005592 creator A5007310901 @default.
• W2955005592 date "2019-06-30" @default.
• W2955005592 modified "2023-09-26" @default.
• W2955005592 title "Salt Inducible Kinase Signaling Networks: Implications for Acute Kidney Injury and Therapeutic Potential" @default.
• W2955005592 cites W1506387083 @default.
• W2955005592 cites W1516311606 @default.
• W2955005592 cites W1518814346 @default.
• W2955005592 cites W1547979311 @default.
• W2955005592 cites W1608481794 @default.
• W2955005592 cites W1970277428 @default.
• W2955005592 cites W1979954613 @default.
• W2955005592 cites W1990638016 @default.
• W2955005592 cites W1998186535 @default.
• W2955005592 cites W2005403372 @default.
• W2955005592 cites W2008776686 @default.
• W2955005592 cites W2009542985 @default.
• W2955005592 cites W2010534999 @default.
• W2955005592 cites W2015257702 @default.
• W2955005592 cites W2019010829 @default.
• W2955005592 cites W2027168735 @default.
• W2955005592 cites W2040022677 @default.
• W2955005592 cites W2042523021 @default.
• W2955005592 cites W2045987655 @default.
• W2955005592 cites W2050197131 @default.
• W2955005592 cites W2053293745 @default.
• W2955005592 cites W2067436965 @default.
• W2955005592 cites W2067463198 @default.
• W2955005592 cites W2067834064 @default.
• W2955005592 cites W2071690740 @default.
• W2955005592 cites W2072102311 @default.
• W2955005592 cites W2073656814 @default.
• W2955005592 cites W2077907378 @default.
• W2955005592 cites W2080203273 @default.
• W2955005592 cites W2083516240 @default.
• W2955005592 cites W2087656113 @default.
• W2955005592 cites W2093309398 @default.
• W2955005592 cites W2097795389 @default.
• W2955005592 cites W2099725882 @default.
• W2955005592 cites W2101264387 @default.
• W2955005592 cites W2101882540 @default.
• W2955005592 cites W2103041436 @default.
• W2955005592 cites W2103341354 @default.
• W2955005592 cites W2104723979 @default.
• W2955005592 cites W2105083182 @default.
• W2955005592 cites W2105691664 @default.
• W2955005592 cites W2107797142 @default.
• W2955005592 cites W2108779014 @default.
• W2955005592 cites W2120338011 @default.
• W2955005592 cites W2124498364 @default.
• W2955005592 cites W2128474411 @default.
• W2955005592 cites W2128611559 @default.
• W2955005592 cites W2130496164 @default.
• W2955005592 cites W2134461114 @default.
• W2955005592 cites W2134992281 @default.
• W2955005592 cites W2141284381 @default.
• W2955005592 cites W2141700579 @default.
• W2955005592 cites W2143209738 @default.
• W2955005592 cites W2144621903 @default.
• W2955005592 cites W2145800004 @default.
• W2955005592 cites W2148210939 @default.
• W2955005592 cites W2155852256 @default.
• W2955005592 cites W2156991338 @default.
• W2955005592 cites W2158748750 @default.
• W2955005592 cites W2162392154 @default.
• W2955005592 cites W2164460363 @default.
• W2955005592 cites W2165991181 @default.
• W2955005592 cites W2166629377 @default.
• W2955005592 cites W2233632661 @default.
• W2955005592 cites W2305012287 @default.
• W2955005592 cites W2501351815 @default.
• W2955005592 cites W2581605534 @default.
• W2955005592 cites W2629753272 @default.
• W2955005592 cites W2756821040 @default.
• W2955005592 cites W2767766003 @default.
• W2955005592 cites W2768553263 @default.
• W2955005592 cites W2773242491 @default.
• W2955005592 cites W2773849864 @default.
• W2955005592 cites W2777131562 @default.
• W2955005592 cites W2788835551 @default.
• W2955005592 cites W2792154144 @default.
• W2955005592 cites W2805715215 @default.
• W2955005592 cites W2806695145 @default.
• W2955005592 cites W2884356778 @default.
• W2955005592 cites W2888508916 @default.
• W2955005592 cites W2893653677 @default.
• W2955005592 cites W2898766522 @default.
• W2955005592 cites W2912964096 @default.
• W2955005592 cites W2914105091 @default.
• W2955005592 cites W2942587356 @default.
• W2955005592 cites W2981992161 @default.
• W2955005592 cites W4230156568 @default.
• W2955005592 doi "https://doi.org/10.3390/ijms20133219" @default.
• W2955005592 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6651122" @default.
• W2955005592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31262033" @default.
• W2955005592 hasPublicationYear "2019" @default.
• W2955005592 type Work @default.

• next