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- W2955013278 abstract "The R and S enantiomers of the antihypertensive drug carvedilol (CVD) can display remarkable miscibility in the crystalline state allowing this active pharmaceutical ingredient (API) to form a solid-solution of enantiomers (SSEs) as well as racemic compounds. Although rare and still little explored, these intriguing systems can also be used to design racemic multicomponent crystal forms toward the improvement of undesirable pharmaceutical properties of APIs. In this study, aiming to understand why there is miscibility between the enantiomers during the supramolecular recognition and crystallization processes of the CVD in the presence of salt formers, two SSEs and one racemic salt were prepared from the reaction of CVD with pharmaceutically acceptable HCl, HBr, and oxalic acids. Two monohydrated isostructural salts, hydrochloride (CVD-HCl-H2O) and hydrobromide (CVD-HBr-H2O), crystallize as racemic SSEs. These unique systems are formed from the miscibility of the R···R and S···S homochiral units that propa..." @default.
- W2955013278 created "2019-07-12" @default.
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- W2955013278 date "2019-06-27" @default.
- W2955013278 modified "2023-10-16" @default.
- W2955013278 title "Racemic Salts and Solid Solutions of Enantiomers of the Antihypertensive Drug Carvedilol" @default.
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- W2955013278 doi "https://doi.org/10.1021/acs.cgd.9b00263" @default.
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