FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955030133> ?p ?o ?g. }

• W2955030133 abstract "ICU-acquired weakness is a debilitating consequence of prolonged critical illness that is associated with poor outcome. Recently, premorbid obesity has been shown to protect against such illness-induced muscle wasting and weakness. Here, we hypothesized that this protection was due to increased lipid and ketone availability.In a centrally catheterized, fluid-resuscitated, antibiotic-treated mouse model of prolonged sepsis, we compared markers of lipolysis and fatty acid oxidation in lean and obese septic mice (n = 117). Next, we compared markers of muscle wasting and weakness in septic obese wild-type and adipose tissue-specific ATGL knockout (AAKO) mice (n = 73), in lean septic mice receiving either intravenous infusion of lipids or standard parenteral nutrition (PN) (n = 70), and in lean septic mice receiving standard PN supplemented with either the ketone body 3-hydroxybutyrate or isocaloric glucose (n = 49).Obese septic mice had more pronounced lipolysis (p ≤ 0.05), peripheral fatty acid oxidation (p ≤ 0.05), and ketogenesis (p ≤ 0.05) than lean mice. Blocking lipolysis in obese septic mice caused severely reduced muscle mass (32% loss vs. 15% in wild-type, p < 0.001) and specific maximal muscle force (59% loss vs. 0% in wild-type; p < 0.001). In contrast, intravenous infusion of lipids in lean septic mice maintained specific maximal muscle force up to healthy control levels (p = 0.6), whereas this was reduced with 28% in septic mice receiving standard PN (p = 0.006). Muscle mass was evenly reduced with 29% in both lean septic groups (p < 0.001). Lipid administration enhanced fatty acid oxidation (p ≤ 0.05) and ketogenesis (p < 0.001), but caused unfavorable liver steatosis (p = 0.01) and a deranged lipid profile (p ≤ 0.01). Supplementation of standard PN with 3-hydroxybutyrate also attenuated specific maximal muscle force up to healthy control levels (p = 0.1), but loss of muscle mass could not be prevented (25% loss in both septic groups; p < 0.001). Importantly, this intervention improved muscle regeneration markers (p ≤ 0.05) without the unfavorable side effects seen with lipid infusion.Obesity-induced muscle protection during sepsis is partly mediated by elevated mobilization and metabolism of endogenous fatty acids. Furthermore, increased availability of ketone bodies, either through ketogenesis or through parenteral infusion, appears to protect against sepsis-induced muscle weakness also in the lean." @default.
• W2955030133 created "2019-07-12" @default.
• W2955030133 creator A5004441682 @default.
• W2955030133 creator A5026725375 @default.
• W2955030133 creator A5028461139 @default.
• W2955030133 creator A5035530316 @default.
• W2955030133 creator A5042145557 @default.
• W2955030133 creator A5043616395 @default.
• W2955030133 creator A5062448241 @default.
• W2955030133 creator A5063477895 @default.
• W2955030133 creator A5084069631 @default.
• W2955030133 creator A5084691397 @default.
• W2955030133 date "2019-07-01" @default.
• W2955030133 modified "2023-10-17" @default.
• W2955030133 title "Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones" @default.
• W2955030133 cites W1595560766 @default.
• W2955030133 cites W1840057839 @default.
• W2955030133 cites W1863136464 @default.
• W2955030133 cites W1870461993 @default.
• W2955030133 cites W1969655939 @default.
• W2955030133 cites W1976550535 @default.
• W2955030133 cites W1976715250 @default.
• W2955030133 cites W1981897621 @default.
• W2955030133 cites W1981956617 @default.
• W2955030133 cites W1984330756 @default.
• W2955030133 cites W1986132654 @default.
• W2955030133 cites W1987306333 @default.
• W2955030133 cites W1996095433 @default.
• W2955030133 cites W1999132689 @default.
• W2955030133 cites W2002233417 @default.
• W2955030133 cites W2015448195 @default.
• W2955030133 cites W2020098484 @default.
• W2955030133 cites W2036097574 @default.
• W2955030133 cites W2036329632 @default.
• W2955030133 cites W2042705095 @default.
• W2955030133 cites W2043442256 @default.
• W2955030133 cites W2051434448 @default.
• W2955030133 cites W2064362822 @default.
• W2955030133 cites W2068555870 @default.
• W2955030133 cites W2071187477 @default.
• W2955030133 cites W2076815798 @default.
• W2955030133 cites W2081262717 @default.
• W2955030133 cites W2086921193 @default.
• W2955030133 cites W2089240196 @default.
• W2955030133 cites W2090727270 @default.
• W2955030133 cites W2091837818 @default.
• W2955030133 cites W2092433027 @default.
• W2955030133 cites W2095109821 @default.
• W2955030133 cites W2101042964 @default.
• W2955030133 cites W2113621578 @default.
• W2955030133 cites W2116663073 @default.
• W2955030133 cites W2116690246 @default.
• W2955030133 cites W2117520303 @default.
• W2955030133 cites W2118240638 @default.
• W2955030133 cites W2123777536 @default.
• W2955030133 cites W2127016297 @default.
• W2955030133 cites W2127738100 @default.
• W2955030133 cites W2128501939 @default.
• W2955030133 cites W2131699531 @default.
• W2955030133 cites W2145796234 @default.
• W2955030133 cites W2145860588 @default.
• W2955030133 cites W2153413087 @default.
• W2955030133 cites W2155631120 @default.
• W2955030133 cites W2158097707 @default.
• W2955030133 cites W2162310928 @default.
• W2955030133 cites W2166952064 @default.
• W2955030133 cites W2190507182 @default.
• W2955030133 cites W2300303513 @default.
• W2955030133 cites W2307805172 @default.
• W2955030133 cites W2326471898 @default.
• W2955030133 cites W2334337188 @default.
• W2955030133 cites W2414472597 @default.
• W2955030133 cites W2418317130 @default.
• W2955030133 cites W2482292220 @default.
• W2955030133 cites W2489350571 @default.
• W2955030133 cites W2498705437 @default.
• W2955030133 cites W2517910168 @default.
• W2955030133 cites W2571040143 @default.
• W2955030133 cites W2588511379 @default.
• W2955030133 cites W2611492630 @default.
• W2955030133 cites W2616348517 @default.
• W2955030133 cites W2739936777 @default.
• W2955030133 cites W2791308801 @default.
• W2955030133 cites W2822036450 @default.
• W2955030133 cites W2890873798 @default.
• W2955030133 cites W2903904023 @default.
• W2955030133 cites W2911205605 @default.
• W2955030133 doi "https://doi.org/10.1186/s13054-019-2506-6" @default.
• W2955030133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6600878" @default.
• W2955030133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31262340" @default.
• W2955030133 hasPublicationYear "2019" @default.
• W2955030133 type Work @default.
• W2955030133 sameAs 2955030133 @default.
• W2955030133 citedByCount "45" @default.
• W2955030133 countsByYear W29550301332020 @default.
• W2955030133 countsByYear W29550301332021 @default.
• W2955030133 countsByYear W29550301332022 @default.
• W2955030133 countsByYear W29550301332023 @default.
• W2955030133 crossrefType "journal-article" @default.
• W2955030133 hasAuthorship W2955030133A5004441682 @default.

• next