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- W2955034138 abstract "The major histocompatibility complex (MHC) is important for adaptive immunity where the MHC molecules bind and present peptides from pathogens to T cells. The peptide binding repertoire of an individual’s MHC molecules determines what pathogens can be recognised by the immune system, and the MHC peptide binding repertoire is therefore under strong selection from pathogens. Parasite and pathogen diversity are known to increase with a decrease in latitude, and this change in pathogen community composition should hence affect the MHC repertoire of the host species. Here, I compare the diversity and divergence of both classical and non-classical MHC class I alleles between four European populations of house sparrows Passer domesticus across a latitudinal gradient, from Spain in the south, through Bulgaria and Poland, to Sweden in the north. I also look at the relationship between MHC diversity/divergence and infection status of three genera of avian malaria parasites (Plasmodium, Haemoproteus and Leucocytozoon). I found that in general, the MHC class I diversity and divergence in the four populations are very similar, while there is a large difference in patterns of selection between classical and non-classical alleles. I only found few associations between parasite infection status and MHC, and only for Plasmodium infections. Despite the considerable population differences in avian malaria infection status the classical MHC class I alleles seem to be under very similar selection, and infection status of avian malaria is unlikely to be explained by MHC class I diversity/divergence in house sparrows in Europe." @default.
- W2955034138 created "2019-07-12" @default.
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- W2955034138 date "2019-01-01" @default.
- W2955034138 modified "2023-09-26" @default.
- W2955034138 title "MHC diversity in house sparrow Passer domesticus in relation to pathogen diversity" @default.
- W2955034138 hasPublicationYear "2019" @default.
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