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- W2955035442 abstract "In this chapter we provide an exhaustive overview of the binding modes of bile acid (BA) and non-BA ligands to the nuclear farnesoid X receptor (FXR) and the G-protein bile acid receptor 1 (GPBAR1). These two receptors play a key role in many diseases related to lipid and glucose disorders, thus representing promising pharmacological targets. We pay particular attention to the chemical and structural features of the ligand-receptor interaction, providing guidelines to achieve ligands endowed with selective or dual activity towards the receptor and paving the way to future drug design studies." @default.
- W2955035442 created "2019-07-12" @default.
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- W2955035442 date "2019-01-01" @default.
- W2955035442 modified "2023-09-25" @default.
- W2955035442 title "Structural Insight into the Binding Mode of FXR and GPBAR1 Modulators" @default.
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- W2955035442 doi "https://doi.org/10.1007/164_2019_234" @default.
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