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- W2955054364 abstract "Objectives The aim of this study was to noninvasively evaluate changes in renal stiffness, diffusion, and oxygenation in patients with chronic, advanced stage immunoglobulin A nephropathy (IgAN) by multiparametric magnetic resonance imaging using tomoelastography, diffusion-weighted imaging (DWI), and blood oxygen level–dependent (BOLD) imaging. Materials and Methods In this prospective study, 32 subjects (16 patients with biopsy-proven IgAN and 16 age- and sex-matched healthy controls) underwent multifrequency magnetic resonance elastography with tomoelastography postprocessing at 4 frequencies from 40 to 70 Hz to generate shear wave speed (meter per second) maps reflecting tissue stiffness. In addition, DWI and BOLD imaging were performed to determine the apparent diffusion coefficient in square millimeter per second and T2* relaxation time in milliseconds, respectively. Regions including the entire renal parenchyma of both kidneys were analyzed. Areas under the receiver operating characteristic (AUCs) curve were calculated to test diagnostic performance. Clinical parameters such as estimated glomerular filtration rate and protein-to-creatinine ratio were determined and correlated with imaging findings. Results Success rates of tomoelastography, DWI, and BOLD imaging regarding both kidneys were 100%, 91%, and 87%, respectively. Shear wave speed was decreased in IgAN (−21%, P < 0.0001), accompanied by lower apparent diffusion coefficient values (−12%, P = 0.004). BOLD imaging was not sensitive to IgAN ( P = 0.12). Tomoelastography detected IgAN with higher diagnostic accuracy than DWI (area under the curve = 0.9 vs 0.8) and positively correlated with estimated glomerular filtration rate ( r = 0.66, P = 0.006). Conclusions Chronic, advanced stage IgAN is associated with renal softening and restricted water diffusion. Tomoelastography is superior to DWI and BOLD imaging in detecting IgAN." @default.
- W2955054364 created "2019-07-12" @default.
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- W2955054364 date "2019-07-01" @default.
- W2955054364 modified "2023-10-16" @default.
- W2955054364 title "Multiparametric Quantitative MRI for the Detection of IgA Nephropathy Using Tomoelastography, DWI, and BOLD Imaging" @default.
- W2955054364 cites W1914305028 @default.
- W2955054364 cites W1967769355 @default.
- W2955054364 cites W1969583173 @default.
- W2955054364 cites W1970252839 @default.
- W2955054364 cites W1973189762 @default.
- W2955054364 cites W1977132250 @default.
- W2955054364 cites W1981722890 @default.
- W2955054364 cites W1999965569 @default.
- W2955054364 cites W2008499737 @default.
- W2955054364 cites W2009435684 @default.
- W2955054364 cites W2021891251 @default.
- W2955054364 cites W2023548286 @default.
- W2955054364 cites W2035940837 @default.
- W2955054364 cites W2045595048 @default.
- W2955054364 cites W2050516721 @default.
- W2955054364 cites W2054582400 @default.
- W2955054364 cites W2055934272 @default.
- W2955054364 cites W2056112657 @default.
- W2955054364 cites W2061958482 @default.
- W2955054364 cites W2068604817 @default.
- W2955054364 cites W2069532873 @default.
- W2955054364 cites W2070059578 @default.
- W2955054364 cites W2078902399 @default.
- W2955054364 cites W2079039756 @default.
- W2955054364 cites W2085837870 @default.
- W2955054364 cites W2093107775 @default.
- W2955054364 cites W2115682581 @default.
- W2955054364 cites W2124897007 @default.
- W2955054364 cites W2128604069 @default.
- W2955054364 cites W2129066180 @default.
- W2955054364 cites W2138774205 @default.
- W2955054364 cites W2139030893 @default.
- W2955054364 cites W2152853007 @default.
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- W2955054364 cites W2155965977 @default.
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- W2955054364 cites W2165001114 @default.
- W2955054364 cites W2212745154 @default.
- W2955054364 cites W2235312129 @default.
- W2955054364 cites W2328856192 @default.
- W2955054364 cites W2330058314 @default.
- W2955054364 cites W2434506096 @default.
- W2955054364 cites W2464086980 @default.
- W2955054364 cites W2496501445 @default.
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- W2955054364 cites W2585400907 @default.
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- W2955054364 cites W2597162430 @default.
- W2955054364 cites W2602196428 @default.
- W2955054364 cites W2608947308 @default.
- W2955054364 cites W2663040675 @default.
- W2955054364 cites W2724355593 @default.
- W2955054364 cites W2727604819 @default.
- W2955054364 cites W2753098682 @default.
- W2955054364 cites W2767737989 @default.
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- W2955054364 cites W2790070377 @default.
- W2955054364 cites W2883936128 @default.
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- W2955054364 doi "https://doi.org/10.1097/rli.0000000000000585" @default.
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