Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955062357> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2955062357 abstract "Background - The ability of medical practitioners to communicate risk estimates effectively to patients diagnosed with melanoma relies on accurate information about prognostic factors and their impact on survival. This study reports the development of one of the few melanoma prognostic models, called the Melanoma Severity Index (MSI) , based on population-based cancer registry data. Methods - Data from the Queensland Cancer Registry for people (20–89 years) diagnosed with a single invasive melanoma between 1995 and 2008 (n = 28,654; 1,700 melanoma deaths). Additional clinical information about metastasis, ulceration and positive lymph nodes was manually extracted from pathology forms. Flexible parametric survival models were combined with multivariable fractional polynomial for selecting variables and transformations of continuous variables. Multiple imputation was used for missing covariate values. Results - The MSI contained the variables thickness (transformed, explained 40.6% of variation in survival), body site (additional 1.9% in variation), metastasis (1.8%), positive nodes (0.7%), ulceration (1.3%), age (1.1%). Royston and Sauerbrei’s D statistic (measure of discrimination) was 1.50 (95% CI = 1.44, 1.56) and the corresponding RD2 (measure of explained variation) was 0.47 (0.45, 0.49), demonstrating strong explanatory performance. The Harrell-C statistic was 0.88 (0.88, 0.89). Lacking an external validation dataset, we applied internal-external cross validation to demonstrate the consistency of the prognostic information across geographically-defined subsets of the cohort. Conclusions - The MSI provides good ability to predict survival for melanoma patients. Beyond the immediate clinical use, the MSI may have important public health and research applications for evaluations of public health interventions aimed at reducing deaths from melanoma." @default.
- W2955062357 created "2019-07-12" @default.
- W2955062357 creator A5006480686 @default.
- W2955062357 creator A5028302734 @default.
- W2955062357 creator A5033476831 @default.
- W2955062357 creator A5043721909 @default.
- W2955062357 creator A5064186655 @default.
- W2955062357 creator A5090853680 @default.
- W2955062357 date "2015-01-01" @default.
- W2955062357 modified "2023-09-24" @default.
- W2955062357 title "Prognostic survival model for people diagnosed with invasive cutaneous melanoma" @default.
- W2955062357 hasPublicationYear "2015" @default.
- W2955062357 type Work @default.
- W2955062357 sameAs 2955062357 @default.
- W2955062357 citedByCount "0" @default.
- W2955062357 crossrefType "journal-article" @default.
- W2955062357 hasAuthorship W2955062357A5006480686 @default.
- W2955062357 hasAuthorship W2955062357A5028302734 @default.
- W2955062357 hasAuthorship W2955062357A5033476831 @default.
- W2955062357 hasAuthorship W2955062357A5043721909 @default.
- W2955062357 hasAuthorship W2955062357A5064186655 @default.
- W2955062357 hasAuthorship W2955062357A5090853680 @default.
- W2955062357 hasConcept C10515644 @default.
- W2955062357 hasConcept C105795698 @default.
- W2955062357 hasConcept C119043178 @default.
- W2955062357 hasConcept C121608353 @default.
- W2955062357 hasConcept C126322002 @default.
- W2955062357 hasConcept C143998085 @default.
- W2955062357 hasConcept C164465091 @default.
- W2955062357 hasConcept C2777658100 @default.
- W2955062357 hasConcept C2778527826 @default.
- W2955062357 hasConcept C2908647359 @default.
- W2955062357 hasConcept C33923547 @default.
- W2955062357 hasConcept C502942594 @default.
- W2955062357 hasConcept C50382708 @default.
- W2955062357 hasConcept C71924100 @default.
- W2955062357 hasConcept C72563966 @default.
- W2955062357 hasConcept C89128539 @default.
- W2955062357 hasConcept C99454951 @default.
- W2955062357 hasConceptScore W2955062357C10515644 @default.
- W2955062357 hasConceptScore W2955062357C105795698 @default.
- W2955062357 hasConceptScore W2955062357C119043178 @default.
- W2955062357 hasConceptScore W2955062357C121608353 @default.
- W2955062357 hasConceptScore W2955062357C126322002 @default.
- W2955062357 hasConceptScore W2955062357C143998085 @default.
- W2955062357 hasConceptScore W2955062357C164465091 @default.
- W2955062357 hasConceptScore W2955062357C2777658100 @default.
- W2955062357 hasConceptScore W2955062357C2778527826 @default.
- W2955062357 hasConceptScore W2955062357C2908647359 @default.
- W2955062357 hasConceptScore W2955062357C33923547 @default.
- W2955062357 hasConceptScore W2955062357C502942594 @default.
- W2955062357 hasConceptScore W2955062357C50382708 @default.
- W2955062357 hasConceptScore W2955062357C71924100 @default.
- W2955062357 hasConceptScore W2955062357C72563966 @default.
- W2955062357 hasConceptScore W2955062357C89128539 @default.
- W2955062357 hasConceptScore W2955062357C99454951 @default.
- W2955062357 hasLocation W29550623571 @default.
- W2955062357 hasOpenAccess W2955062357 @default.
- W2955062357 hasPrimaryLocation W29550623571 @default.
- W2955062357 hasRelatedWork W1846062424 @default.
- W2955062357 hasRelatedWork W2000127918 @default.
- W2955062357 hasRelatedWork W2081984856 @default.
- W2955062357 hasRelatedWork W2103268198 @default.
- W2955062357 hasRelatedWork W2157171928 @default.
- W2955062357 hasRelatedWork W2186190716 @default.
- W2955062357 hasRelatedWork W2409050497 @default.
- W2955062357 hasRelatedWork W2460712522 @default.
- W2955062357 hasRelatedWork W2617924944 @default.
- W2955062357 hasRelatedWork W2713575692 @default.
- W2955062357 hasRelatedWork W2738161239 @default.
- W2955062357 hasRelatedWork W2887086731 @default.
- W2955062357 hasRelatedWork W2904953226 @default.
- W2955062357 hasRelatedWork W2947284867 @default.
- W2955062357 hasRelatedWork W3110458002 @default.
- W2955062357 hasRelatedWork W3115887203 @default.
- W2955062357 hasRelatedWork W3138524771 @default.
- W2955062357 hasRelatedWork W3157444782 @default.
- W2955062357 hasRelatedWork W3204588521 @default.
- W2955062357 hasRelatedWork W2742041236 @default.
- W2955062357 isParatext "false" @default.
- W2955062357 isRetracted "false" @default.
- W2955062357 magId "2955062357" @default.
- W2955062357 workType "article" @default.