FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955065957> ?p ?o ?g. }

• W2955065957 endingPage "2306" @default.
• W2955065957 startingPage "2298" @default.
• W2955065957 abstract "BackgroundThe human genome is an under-researched area of pre-operative risk stratification. Studies of genetic polymorphisms and their associations with acute post-operative complications in gastrointestinal surgery have reported statistically significant results, but have varied in methodology, genetic variations studied, and conclusions reached. To provide clarity, we conducted a systematic review and meta-analysis of single nucleotide polymorphisms and their association with post-operative complications after major gastrointestinal surgery.MethodsWe performed a literature search using Ovid MEDLINE and Web of Science databases. Studies were included if they investigated genetic polymorphisms and their associations with post-operative complications after major gastrointestinal surgery. We extracted clinical and genetic data from each paper and assessed for quality against the STrengthening the REporting of Genetic Association Studies (STREGA) guidelines. Odds ratios were presented, with 95% confidence intervals, to assess strengths of association. We conducted a meta-analysis on TNF-α-308, which had been assessed in three papers.ResultsOur search returned 68 papers, of which 5 were included after screening and full-text review. Twenty-two different single nucleotide polymorphisms (SNPs) were investigated in these studies. We found that all papers were genetic association studies, and had selected SNPs related to inflammation. The outcome investigated was most commonly post-operative infection, but also anastomotic leak and other non-infectious complications. Statistically significant associations were found for TNF-α-308, IL-10-819, PTGS2-765 and IFN-γ-874. There was significant variability in study quality and methodology. We conducted a meta-analysis on associations between the TNF-α-308 polymorphism and post-operative infection and report an OR of 1.18 (CI 0.27–5.21).ConclusionsWe found biologically plausible associations between SNPs involved in inflammation and post-operative infection, but the available data were too limited and of insufficient quality to reach definitive conclusions. Further work is needed, including genome-wide association studies (GWAS)." @default.
• W2955065957 created "2019-07-12" @default.
• W2955065957 creator A5010892830 @default.
• W2955065957 creator A5011093165 @default.
• W2955065957 creator A5037708178 @default.
• W2955065957 creator A5081484621 @default.
• W2955065957 creator A5081721618 @default.
• W2955065957 creator A5091733390 @default.
• W2955065957 date "2019-07-03" @default.
• W2955065957 modified "2023-09-26" @default.
• W2955065957 title "Single Nucleotide Polymorphisms and Post-operative Complications Following Major Gastrointestinal Surgery: a Systematic Review and Meta-analysis" @default.
• W2955065957 cites W1552557715 @default.
• W2955065957 cites W1572664742 @default.
• W2955065957 cites W1964249139 @default.
• W2955065957 cites W1967854693 @default.
• W2955065957 cites W1976407348 @default.
• W2955065957 cites W1983526913 @default.
• W2955065957 cites W1985391068 @default.
• W2955065957 cites W1989464452 @default.
• W2955065957 cites W1989915637 @default.
• W2955065957 cites W1999790144 @default.
• W2955065957 cites W2002295754 @default.
• W2955065957 cites W2006512807 @default.
• W2955065957 cites W2013758316 @default.
• W2955065957 cites W2013856377 @default.
• W2955065957 cites W2029726196 @default.
• W2955065957 cites W2044341962 @default.
• W2955065957 cites W2047425974 @default.
• W2955065957 cites W2061542205 @default.
• W2955065957 cites W2072026981 @default.
• W2955065957 cites W2074796887 @default.
• W2955065957 cites W2076801509 @default.
• W2955065957 cites W2079476742 @default.
• W2955065957 cites W2083513831 @default.
• W2955065957 cites W2088964047 @default.
• W2955065957 cites W2091461133 @default.
• W2955065957 cites W2101984812 @default.
• W2955065957 cites W2106631668 @default.
• W2955065957 cites W2115904199 @default.
• W2955065957 cites W2136494006 @default.
• W2955065957 cites W2141380939 @default.
• W2955065957 cites W2143249342 @default.
• W2955065957 cites W2150299512 @default.
• W2955065957 cites W2150888083 @default.
• W2955065957 cites W2155047516 @default.
• W2955065957 cites W2156098321 @default.
• W2955065957 cites W2162235775 @default.
• W2955065957 cites W2280404143 @default.
• W2955065957 cites W2289421380 @default.
• W2955065957 cites W2302003756 @default.
• W2955065957 cites W2339990273 @default.
• W2955065957 cites W2396212074 @default.
• W2955065957 cites W2510715352 @default.
• W2955065957 cites W2603997054 @default.
• W2955065957 cites W2763593805 @default.
• W2955065957 cites W2772239904 @default.
• W2955065957 cites W2772627217 @default.
• W2955065957 cites W2886045313 @default.
• W2955065957 cites W2955065957 @default.
• W2955065957 cites W2991792334 @default.
• W2955065957 cites W3010375608 @default.
• W2955065957 cites W4211176474 @default.
• W2955065957 cites W4249424686 @default.
• W2955065957 cites W70909939 @default.
• W2955065957 doi "https://doi.org/10.1007/s11605-019-04300-2" @default.
• W2955065957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6831536" @default.
• W2955065957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31270721" @default.
• W2955065957 hasPublicationYear "2019" @default.
• W2955065957 type Work @default.
• W2955065957 sameAs 2955065957 @default.
• W2955065957 citedByCount "2" @default.
• W2955065957 countsByYear W29550659572019 @default.
• W2955065957 crossrefType "journal-article" @default.
• W2955065957 hasAuthorship W2955065957A5010892830 @default.
• W2955065957 hasAuthorship W2955065957A5011093165 @default.
• W2955065957 hasAuthorship W2955065957A5037708178 @default.
• W2955065957 hasAuthorship W2955065957A5081484621 @default.
• W2955065957 hasAuthorship W2955065957A5081721618 @default.
• W2955065957 hasAuthorship W2955065957A5091733390 @default.
• W2955065957 hasBestOaLocation W29550659571 @default.
• W2955065957 hasConcept C104317684 @default.
• W2955065957 hasConcept C106208931 @default.
• W2955065957 hasConcept C126322002 @default.
• W2955065957 hasConcept C135763542 @default.
• W2955065957 hasConcept C141071460 @default.
• W2955065957 hasConcept C153209595 @default.
• W2955065957 hasConcept C156957248 @default.
• W2955065957 hasConcept C186413461 @default.
• W2955065957 hasConcept C2779473830 @default.
• W2955065957 hasConcept C44249647 @default.
• W2955065957 hasConcept C54355233 @default.
• W2955065957 hasConcept C55493867 @default.
• W2955065957 hasConcept C60644358 @default.
• W2955065957 hasConcept C71924100 @default.
• W2955065957 hasConcept C86803240 @default.
• W2955065957 hasConcept C95190672 @default.
• W2955065957 hasConceptScore W2955065957C104317684 @default.
• W2955065957 hasConceptScore W2955065957C106208931 @default.

• next