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• W2955069509 endingPage "19.2019" @default.
• W2955069509 startingPage "ENEURO.0181" @default.
• W2955069509 abstract "Abstract During early postnatal life, speed up of signal propagation through many central and peripheral neurons has been associated with an increase in axon diameter or/and myelination. Especially in unmyelinated axons postnatal adjustments of axonal membrane conductances is potentially a third mechanism but solid evidence is lacking. Here, we show that axonal action potential (AP) conduction velocity in the Drosophila giant fiber (GF) interneuron, which is required for fast long-distance signal conduction through the escape circuit, is increased by 80% during the first day of adult life. Genetic manipulations indicate that this postnatal increase in AP conduction velocity in the unmyelinated GF axon is likely owed to adjustments of ion channel expression or properties rather than axon diameter increases. Specifically, targeted RNAi knock-down of either Para fast voltage-gated sodium, Shaker potassium ( Kv1 homologue), or surprisingly, L-type like calcium channels counteracts postnatal increases in GF axonal conduction velocity. By contrast, the calcium-dependent potassium channel Slowpoke (BK) is not essential for postnatal speeding, although it also significantly increases conduction velocity. Therefore, we identified multiple ion channels that function to support fast axonal AP conduction velocity, but only a subset of these are regulated during early postnatal life to maximize conduction velocity. Despite its large diameter (∼7 µm) and postnatal regulation of multiple ionic conductances, mature GF axonal conduction velocity is still 20–60 times slower than that of vertebrate Aβ sensory axons and α motoneurons, thus unraveling the limits of long-range information transfer speed through invertebrate circuits." @default.
• W2955069509 created "2019-07-12" @default.
• W2955069509 creator A5009763589 @default.
• W2955069509 creator A5021719922 @default.
• W2955069509 creator A5030891600 @default.
• W2955069509 date "2019-06-28" @default.
• W2955069509 modified "2023-10-16" @default.
• W2955069509 title "Postnatal Increases in Axonal Conduction Velocity of an Identified<i>Drosophila</i>Interneuron Require Fast Sodium, L-Type Calcium and Shaker Potassium Channels" @default.
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