FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955100032> ?p ?o ?g. }

• W2955100032 endingPage "1592" @default.
• W2955100032 startingPage "1586" @default.
• W2955100032 abstract "Nonalcoholic fatty liver disease (NAFLD) is the commonest liver disease in children and adolescents in Western countries. Complex traits arise from the interplay between environmental and genetic factors in the pathogenesis of NAFLD.We examined the association between NAFLD and eleven single nucleotide polymorphisms (SNPs) at genetic loci potentially associated with liver damage (GCKR, MBOAT7, GPR120), oxidative stress (SOD2), lipid metabolism (PNPLA3, TM6SF2, LPIN1, ELOVL2, FADS2, MTTP) and fibrogenesis (KLF6) in a paediatric population. A genetic risk score (GRS) was performed taking into account both these SNPs and clinical risk factors.We recruited a cohort of 514 obese children and adolescents (mean age [±SD]: 11.2 ± 2.8 years, z-BMI 3.3 ± 0.8). NAFLD was identified by ultrasonography. Genotyping was performed by TaqMan-based RT-PCR system.The overall prevalence of NAFLD was 67.5% (347 patients). Among the eleven genotyped SNPs, the genetic variants in TM6SF2 rs58542926 (OR = 4.13, p = 0.002), GCKR rs1260326 (OR = 1.53, p = 0.003), PNPLA3 rs738409 (OR = 1.58, p = 0.004) and ELOVL2 rs2236212 (OR = 1.34, p = 0.047) were significantly associated with a higher risk of NAFLD. Addition of a 11-polymorphism GRS to established clinical risk factors significantly (albeit modestly) improved the discriminatory capability of the regression model for predicting the risk of NAFLD (with SNPs C-statistic 0.81 [95%CI 0.75-0.88] vs. 0.77 [0.70-0.84] without SNPs; p = 0.047).NAFLD was strongly associated with three genetic variants, TM6SF2 rs58542926, PNPLA3 rs738409 and GCKR rs1260326, and more slightly with ELOVL2 rs2236212, in obese children and adolescents. Addition of a 11-polymorphism GRS to clinical risk factors improved the predictability of NAFLD." @default.
• W2955100032 created "2019-07-12" @default.
• W2955100032 creator A5002417160 @default.
• W2955100032 creator A5028501748 @default.
• W2955100032 creator A5034234671 @default.
• W2955100032 creator A5036950034 @default.
• W2955100032 creator A5050497878 @default.
• W2955100032 creator A5052515311 @default.
• W2955100032 creator A5065186921 @default.
• W2955100032 creator A5071075382 @default.
• W2955100032 creator A5075103514 @default.
• W2955100032 creator A5088921771 @default.
• W2955100032 creator A5090673306 @default.
• W2955100032 date "2019-11-01" @default.
• W2955100032 modified "2023-10-16" @default.
• W2955100032 title "Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents" @default.
• W2955100032 cites W1153748316 @default.
• W2955100032 cites W155379592 @default.
• W2955100032 cites W1614032175 @default.
• W2955100032 cites W1852438813 @default.
• W2955100032 cites W1937575131 @default.
• W2955100032 cites W1965294547 @default.
• W2955100032 cites W1999473975 @default.
• W2955100032 cites W2006154918 @default.
• W2955100032 cites W2013231825 @default.
• W2955100032 cites W2031719447 @default.
• W2955100032 cites W2084967585 @default.
• W2955100032 cites W2097695579 @default.
• W2955100032 cites W2104783966 @default.
• W2955100032 cites W2125817947 @default.
• W2955100032 cites W2126285374 @default.
• W2955100032 cites W2136847524 @default.
• W2955100032 cites W2148924243 @default.
• W2955100032 cites W2156760391 @default.
• W2955100032 cites W2161633633 @default.
• W2955100032 cites W2164252555 @default.
• W2955100032 cites W2164389437 @default.
• W2955100032 cites W2164898770 @default.
• W2955100032 cites W2181968362 @default.
• W2955100032 cites W2209432850 @default.
• W2955100032 cites W2254967598 @default.
• W2955100032 cites W2262495123 @default.
• W2955100032 cites W2406424521 @default.
• W2955100032 cites W2606245614 @default.
• W2955100032 cites W2607779679 @default.
• W2955100032 cites W2760949984 @default.
• W2955100032 cites W2767801219 @default.
• W2955100032 cites W2788104827 @default.
• W2955100032 cites W2792563335 @default.
• W2955100032 cites W2795117747 @default.
• W2955100032 cites W2801918135 @default.
• W2955100032 cites W2885265365 @default.
• W2955100032 cites W2885981315 @default.
• W2955100032 cites W2901599876 @default.
• W2955100032 cites W3143409077 @default.
• W2955100032 doi "https://doi.org/10.1016/j.dld.2019.05.029" @default.
• W2955100032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31255630" @default.
• W2955100032 hasPublicationYear "2019" @default.
• W2955100032 type Work @default.
• W2955100032 sameAs 2955100032 @default.
• W2955100032 citedByCount "34" @default.
• W2955100032 countsByYear W29551000322019 @default.
• W2955100032 countsByYear W29551000322020 @default.
• W2955100032 countsByYear W29551000322021 @default.
• W2955100032 countsByYear W29551000322022 @default.
• W2955100032 countsByYear W29551000322023 @default.
• W2955100032 crossrefType "journal-article" @default.
• W2955100032 hasAuthorship W2955100032A5002417160 @default.
• W2955100032 hasAuthorship W2955100032A5028501748 @default.
• W2955100032 hasAuthorship W2955100032A5034234671 @default.
• W2955100032 hasAuthorship W2955100032A5036950034 @default.
• W2955100032 hasAuthorship W2955100032A5050497878 @default.
• W2955100032 hasAuthorship W2955100032A5052515311 @default.
• W2955100032 hasAuthorship W2955100032A5065186921 @default.
• W2955100032 hasAuthorship W2955100032A5071075382 @default.
• W2955100032 hasAuthorship W2955100032A5075103514 @default.
• W2955100032 hasAuthorship W2955100032A5088921771 @default.
• W2955100032 hasAuthorship W2955100032A5090673306 @default.
• W2955100032 hasBestOaLocation W29551000322 @default.
• W2955100032 hasConcept C104317684 @default.
• W2955100032 hasConcept C126322002 @default.
• W2955100032 hasConcept C135763542 @default.
• W2955100032 hasConcept C153209595 @default.
• W2955100032 hasConcept C2776175330 @default.
• W2955100032 hasConcept C2776954865 @default.
• W2955100032 hasConcept C2778772119 @default.
• W2955100032 hasConcept C2779134260 @default.
• W2955100032 hasConcept C2908647359 @default.
• W2955100032 hasConcept C2992519594 @default.
• W2955100032 hasConcept C54355233 @default.
• W2955100032 hasConcept C60644358 @default.
• W2955100032 hasConcept C71924100 @default.
• W2955100032 hasConcept C72563966 @default.
• W2955100032 hasConcept C86803240 @default.
• W2955100032 hasConcept C90924648 @default.
• W2955100032 hasConcept C99454951 @default.
• W2955100032 hasConceptScore W2955100032C104317684 @default.
• W2955100032 hasConceptScore W2955100032C126322002 @default.

• next