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- W2955109620 endingPage "2117" @default.
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- W2955109620 abstract "Supramolecular receptors such as water‐soluble calixarenes are in development as ‘molecular glues’ for protein assembly. Here, we obtained cocrystals of sulfonato‐calix[6]arene ( sclx 6 ) and yeast cytochrome c (cyt c ) in the presence of imidazole. A crystal structure at 2.65 Å resolution reveals major structural rearrangement and disorder in imidazole‐bound cyt c . The largest protein‐calixarene interface involves 440 Å 2 of the protein surface with key contacts at Arg13, Lys73, and Lys79. These lysines participate in alkaline transitions of cyt c and are part of Ω‐loop D, which is substantially restructured in the complex with sclx 6 . The structural modification also includes Ω‐loop C, which is disordered (residues 41–55 inclusive). These results suggest the possibility of using supramolecular scaffolds to trap partially disordered proteins." @default.
- W2955109620 created "2019-07-12" @default.
- W2955109620 creator A5047743762 @default.
- W2955109620 creator A5065055607 @default.
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- W2955109620 date "2019-07-07" @default.
- W2955109620 modified "2023-09-30" @default.
- W2955109620 title "Calixarene capture of partially unfolded cytochrome <i>c</i>" @default.
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- W2955109620 doi "https://doi.org/10.1002/1873-3468.13512" @default.
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