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- W2955113260 abstract "Abstract Fertilization and early embryo development are regulated by a unique maternal-gamete/embryo cross-talk within the oviduct. Recent studies have shown that extracellular vesicles (EVs) within the oviduct play important roles in mediating this developmental process. Here, we examined the influence of oviductal EVs on sperm function in the domestic cat. We demonstrated that (1) EVs are enriched in proteins related to energy metabolism, membrane modification, and reproductive function; (2) EVs bound and fused with the membranes of the acrosome and mid piece; and (3) incubating sperm with EVs improved motility, fertilizing capacity of cat spermatozoa and prevented acrosomal exocytosis in vitro . These findings indicated that oviductal EVs mediate sperm function and fertilization in the cat and provides new insights to improve sperm cryopreservation and in vitro fertilization in the domestic and wild felids and human." @default.
- W2955113260 created "2019-07-12" @default.
- W2955113260 creator A5039312791 @default.
- W2955113260 creator A5039821933 @default.
- W2955113260 creator A5061244299 @default.
- W2955113260 creator A5067432745 @default.
- W2955113260 creator A5067604175 @default.
- W2955113260 date "2019-07-01" @default.
- W2955113260 modified "2023-10-13" @default.
- W2955113260 title "Oviductal extracellular vesicles interact with the spermatozoon’s head and mid-piece and improves its motility and fertilizing ability in the domestic cat" @default.
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- W2955113260 doi "https://doi.org/10.1038/s41598-019-45857-x" @default.
- W2955113260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6603010" @default.
- W2955113260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31263184" @default.
- W2955113260 hasPublicationYear "2019" @default.
- W2955113260 type Work @default.