FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955116249> ?p ?o ?g. }

• W2955116249 abstract "The kidney is an essential organ required by the body to perform several important functions. Nephrotoxicity is one of the most prevailing kidney complications that result from exposure to an extrinsic or intrinsic toxicant, which increase the need for the acquisition of proper remedies. Recently, natural remedies are gaining great attention owed to the fact that they have fewer side effects than most conventional drugs.The current study recorded a new therapeutic role of the well-known medicinal plants for kidney stones [Ammi visnaga (AVE), Petroselinum crispum (PCE), Hordeum vulgare (HVE), and Cymbopogon schoenanthus (CSE)]. Hence, the aqueous extracts of these plants examined against CCl4-induced toxicity in mammalian kidney (Vero) cells.These extracts showed the presence of varying amounts of phenolic and triterpenoid compounds, as well as vitamin C. Owing to the antioxidant potential of these constituents, the extracts suppressed the CCl4-induced oxidative stress significantly (p < 0.05) by scavenging the reactive oxygen species and enhancing the cellular antioxidant indices. In addition, these extracts significantly (p < 0.05) reduced the CCl4-induced inflammation by inhibiting the gene expression of NF-кB, iNOS, and in turn the level of nitric oxide. Consequently, the morphological appearance of Vero cells, cellular necrosis, and the gene expression of kidney injury molecule-1 (a marker of renal injury) after these treatments were improved. The AVE improved CCl4-induced oxidative and inflammatory stress in Vero cells and showed a more potent effect than the commonly used alpha-Ketoanalogue drug (ketosteril) in most of the studied assays.Thus, the studied plant extracts, especially AVE can be considered as promising extracts in the management of nephrotoxicity and other chronic diseases associated with oxidative stress and inflammation." @default.
• W2955116249 created "2019-07-12" @default.
• W2955116249 creator A5054611309 @default.
• W2955116249 creator A5056407508 @default.
• W2955116249 creator A5069557540 @default.
• W2955116249 date "2019-06-25" @default.
• W2955116249 modified "2023-10-17" @default.
• W2955116249 title "In vitro anti-nephrotoxic potential of Ammi visnaga, Petroselinum crispum, Hordeum vulgare, and Cymbopogon schoenanthus seed or leaf extracts by suppressing the necrotic mediators, oxidative stress and inflammation" @default.
• W2955116249 cites W11028296 @default.
• W2955116249 cites W1508864823 @default.
• W2955116249 cites W1526856981 @default.
• W2955116249 cites W1590663869 @default.
• W2955116249 cites W1617495083 @default.
• W2955116249 cites W1714103394 @default.
• W2955116249 cites W1743905762 @default.
• W2955116249 cites W1970256855 @default.
• W2955116249 cites W1972949428 @default.
• W2955116249 cites W1974082153 @default.
• W2955116249 cites W1978993516 @default.
• W2955116249 cites W1983093162 @default.
• W2955116249 cites W1983310681 @default.
• W2955116249 cites W1988342712 @default.
• W2955116249 cites W1996381393 @default.
• W2955116249 cites W2000234104 @default.
• W2955116249 cites W2003729005 @default.
• W2955116249 cites W2006370393 @default.
• W2955116249 cites W2012991711 @default.
• W2955116249 cites W2021962688 @default.
• W2955116249 cites W2021988356 @default.
• W2955116249 cites W2031596649 @default.
• W2955116249 cites W2035078133 @default.
• W2955116249 cites W2035457329 @default.
• W2955116249 cites W2041683357 @default.
• W2955116249 cites W2042831098 @default.
• W2955116249 cites W2043733949 @default.
• W2955116249 cites W2054710412 @default.
• W2955116249 cites W2060194897 @default.
• W2955116249 cites W2084688412 @default.
• W2955116249 cites W2086667809 @default.
• W2955116249 cites W2088866343 @default.
• W2955116249 cites W2090177700 @default.
• W2955116249 cites W2095071219 @default.
• W2955116249 cites W2114918609 @default.
• W2955116249 cites W2128635872 @default.
• W2955116249 cites W2140300290 @default.
• W2955116249 cites W2171272027 @default.
• W2955116249 cites W2259983755 @default.
• W2955116249 cites W2297234050 @default.
• W2955116249 cites W2521574223 @default.
• W2955116249 cites W2558191198 @default.
• W2955116249 cites W2574640858 @default.
• W2955116249 cites W2610801640 @default.
• W2955116249 cites W2725743431 @default.
• W2955116249 cites W2767666478 @default.
• W2955116249 cites W2778708337 @default.
• W2955116249 cites W2789428295 @default.
• W2955116249 cites W2794344015 @default.
• W2955116249 cites W2805227313 @default.
• W2955116249 cites W2885742683 @default.
• W2955116249 cites W2911598883 @default.
• W2955116249 cites W4239280467 @default.
• W2955116249 cites W4293247451 @default.
• W2955116249 doi "https://doi.org/10.1186/s12906-019-2559-8" @default.
• W2955116249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593595" @default.
• W2955116249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31238921" @default.
• W2955116249 hasPublicationYear "2019" @default.
• W2955116249 type Work @default.
• W2955116249 sameAs 2955116249 @default.
• W2955116249 citedByCount "17" @default.
• W2955116249 countsByYear W29551162492020 @default.
• W2955116249 countsByYear W29551162492021 @default.
• W2955116249 countsByYear W29551162492022 @default.
• W2955116249 countsByYear W29551162492023 @default.
• W2955116249 crossrefType "journal-article" @default.
• W2955116249 hasAuthorship W2955116249A5054611309 @default.
• W2955116249 hasAuthorship W2955116249A5056407508 @default.
• W2955116249 hasAuthorship W2955116249A5069557540 @default.
• W2955116249 hasBestOaLocation W29551162491 @default.
• W2955116249 hasConcept C126189478 @default.
• W2955116249 hasConcept C134018914 @default.
• W2955116249 hasConcept C185592680 @default.
• W2955116249 hasConcept C2776151105 @default.
• W2955116249 hasConcept C2778004101 @default.
• W2955116249 hasConcept C2779703632 @default.
• W2955116249 hasConcept C2780091579 @default.
• W2955116249 hasConcept C48349386 @default.
• W2955116249 hasConcept C55493867 @default.
• W2955116249 hasConcept C556039675 @default.
• W2955116249 hasConcept C71924100 @default.
• W2955116249 hasConcept C86803240 @default.
• W2955116249 hasConcept C98274493 @default.
• W2955116249 hasConceptScore W2955116249C126189478 @default.
• W2955116249 hasConceptScore W2955116249C134018914 @default.
• W2955116249 hasConceptScore W2955116249C185592680 @default.
• W2955116249 hasConceptScore W2955116249C2776151105 @default.
• W2955116249 hasConceptScore W2955116249C2778004101 @default.
• W2955116249 hasConceptScore W2955116249C2779703632 @default.
• W2955116249 hasConceptScore W2955116249C2780091579 @default.
• W2955116249 hasConceptScore W2955116249C48349386 @default.
• W2955116249 hasConceptScore W2955116249C55493867 @default.

• next