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• W2955120886 abstract "Objective Clinoidal meningiomas present specific characteristics related to their peculiar site of anatomic origin. Clinical series focusing on pure clinoidal meningiomas are not numerous. We performed a systematic review and meta-analysis, including our own case series, of the available literature to better identify the specific features of these tumors. Methods A systematic review and meta-analysis were performed for surgically treated pure clinoidal meningiomas using PubMed, Cochrane, and Embase databases. A retrospective review of a cohort of 18 consecutive patients treated between 2010 and 2018 in our department was also included in this meta-analysis. Results A total of 1208 patients were included in the analysis. With a weighted mean follow-up of 48.1 months, the pooled rate of gross total resection was 64.2% (95% confidence interval [CI], 57.3%–71.0%) in the overall population, 11.8% (95% CI, 2.4%–21.1%) in the Al-Mefty I subgroup, 92.6% (95% CI, 88.9%–96.3%) in the Al-Mefty II subgroup, and 84.2% (95% CI, 70.8%–97.6%) in the Al-Mefty III subgroup. Overall visual improvement after treatment was found in 48% (95% CI, 38.6%–57.4%) of patients with a pooled deterioration rate of 4.5% (95% CI, 3%–6%). Pooled overall recurrence was observed in 8.9% of patients (95% CI, 6.0%–11.8%) and mortality occurred in 1.2% (95% CI, 0.6%–1.8%). Conclusions The rate of gross total resection is proportional to the dural origin of these tumors, which is intimately related to critical neurovascular structures. Complementary radiosurgery could represent a valid treatment strategy. Postoperative visual improvement remains less satisfying compared with other suprasellar meningiomas. The introduction of skull-base techniques, such as extradural anterior clinoidectomy, has enabled improvements in visual outcome without any increase in approach-related morbidity." @default.
• W2955120886 created "2019-07-12" @default.
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• W2955120886 date "2019-09-01" @default.
• W2955120886 modified "2023-09-26" @default.
• W2955120886 title "Surgery for Clinoidal Meningiomas: Case Series and Meta-Analysis of Outcomes and Complications" @default.
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• W2955120886 doi "https://doi.org/10.1016/j.wneu.2019.05.253" @default.
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