FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955141070> ?p ?o ?g. }

• W2955141070 abstract "Abstract Ttriple-negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype. Enhanced TNBC cell motility is a prerequisite of TNBC cell dissemination. Here, we apply an imaging-based RNAi phenotypic cell migration screen using two highly motile TNBC cell lines (Hs578T and MDA-MB-231) to provide a repository of signaling determinants that functionally drive TNBC cell motility. We have screened ~4,200 target genes individually and discovered 133 and 113 migratory modulators of Hs578T and MDA-MB-231, respectively, which are linked to signaling networks predictive for breast cancer progression. The splicing factors PRPF4B and BUD31 and the transcription factor BPTF are essential for cancer cell migration, amplified in human primary breast tumors and associated with metastasis-free survival. Depletion of PRPF4B , BUD31 and BPTF causes primarily down regulation of genes involved in focal adhesion and ECM-interaction pathways. PRPF4B is essential for TNBC metastasis formation in vivo, making PRPF4B a candidate for further drug development." @default.
• W2955141070 created "2019-07-12" @default.
• W2955141070 creator A5013888438 @default.
• W2955141070 creator A5023698970 @default.
• W2955141070 creator A5025697366 @default.
• W2955141070 creator A5028068407 @default.
• W2955141070 creator A5032601713 @default.
• W2955141070 creator A5037254684 @default.
• W2955141070 creator A5043655122 @default.
• W2955141070 creator A5066680524 @default.
• W2955141070 creator A5066926133 @default.
• W2955141070 creator A5071991781 @default.
• W2955141070 creator A5072004430 @default.
• W2955141070 creator A5079548712 @default.
• W2955141070 creator A5081238239 @default.
• W2955141070 creator A5081295579 @default.
• W2955141070 creator A5085632952 @default.
• W2955141070 date "2019-07-05" @default.
• W2955141070 modified "2023-10-06" @default.
• W2955141070 title "Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes" @default.
• W2955141070 cites W1263857580 @default.
• W2955141070 cites W1497822707 @default.
• W2955141070 cites W1577573926 @default.
• W2955141070 cites W1940048983 @default.
• W2955141070 cites W1967066174 @default.
• W2955141070 cites W1979486580 @default.
• W2955141070 cites W1979946545 @default.
• W2955141070 cites W1990848127 @default.
• W2955141070 cites W1999728161 @default.
• W2955141070 cites W2000567082 @default.
• W2955141070 cites W2000759232 @default.
• W2955141070 cites W2009258895 @default.
• W2955141070 cites W2009707750 @default.
• W2955141070 cites W2010422325 @default.
• W2955141070 cites W2021880490 @default.
• W2955141070 cites W2027374652 @default.
• W2955141070 cites W2032240256 @default.
• W2955141070 cites W2045909049 @default.
• W2955141070 cites W2048187837 @default.
• W2955141070 cites W2049110540 @default.
• W2955141070 cites W2064455466 @default.
• W2955141070 cites W2066231767 @default.
• W2955141070 cites W2080232352 @default.
• W2955141070 cites W2082833890 @default.
• W2955141070 cites W2086011639 @default.
• W2955141070 cites W2088160256 @default.
• W2955141070 cites W2091817614 @default.
• W2955141070 cites W2098952156 @default.
• W2955141070 cites W2102278945 @default.
• W2955141070 cites W2107554012 @default.
• W2955141070 cites W2113516035 @default.
• W2955141070 cites W2116477728 @default.
• W2955141070 cites W2118413367 @default.
• W2955141070 cites W2119204091 @default.
• W2955141070 cites W2123752216 @default.
• W2955141070 cites W2128985829 @default.
• W2955141070 cites W2130410032 @default.
• W2955141070 cites W2132264780 @default.
• W2955141070 cites W2147326210 @default.
• W2955141070 cites W2150671673 @default.
• W2955141070 cites W2151014102 @default.
• W2955141070 cites W2154430605 @default.
• W2955141070 cites W2163563958 @default.
• W2955141070 cites W2165439432 @default.
• W2955141070 cites W2165734811 @default.
• W2955141070 cites W2165776880 @default.
• W2955141070 cites W2168183581 @default.
• W2955141070 cites W2170480204 @default.
• W2955141070 cites W2179438025 @default.
• W2955141070 cites W2292593918 @default.
• W2955141070 cites W2342628598 @default.
• W2955141070 cites W2344657883 @default.
• W2955141070 cites W2430731787 @default.
• W2955141070 cites W2524329031 @default.
• W2955141070 cites W2528745510 @default.
• W2955141070 cites W2571554990 @default.
• W2955141070 cites W2621021029 @default.
• W2955141070 cites W2621300471 @default.
• W2955141070 cites W2641905542 @default.
• W2955141070 cites W2739511077 @default.
• W2955141070 cites W2741508285 @default.
• W2955141070 cites W2746672093 @default.
• W2955141070 cites W2785559034 @default.
• W2955141070 cites W2807284775 @default.
• W2955141070 cites W2890052597 @default.
• W2955141070 cites W3143308366 @default.
• W2955141070 cites W4211233744 @default.
• W2955141070 doi "https://doi.org/10.1038/s41467-019-11020-3" @default.
• W2955141070 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6611796" @default.
• W2955141070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31278301" @default.
• W2955141070 hasPublicationYear "2019" @default.
• W2955141070 type Work @default.
• W2955141070 sameAs 2955141070 @default.
• W2955141070 citedByCount "51" @default.
• W2955141070 countsByYear W29551410702019 @default.
• W2955141070 countsByYear W29551410702020 @default.
• W2955141070 countsByYear W29551410702021 @default.
• W2955141070 countsByYear W29551410702022 @default.
• W2955141070 countsByYear W29551410702023 @default.
• W2955141070 crossrefType "journal-article" @default.

• next