Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955145714> ?p ?o ?g. }
- W2955145714 abstract "Tendinopathy, degeneration of tendon that leads to pain and dysfunction, is common in both sports and occupational settings, but the mechanisms for tendinopathy are still unknown. Many studies attribute the initiation of tendinopathy to damage initiated by mechanical loading, leading to microstructural changes. Yet, the link between mechanical loading and microstructural changes, resulting in macroscopic changes, is not fully elucidated. Thus, the objective of the dissertation was to investigate the damage mechanisms and hierarchical structure of non-load- and load-bearing rat tendons, including the tail, plantaris, and Achilles tendons. Damage is defined as an irreversible change in micro-scale deformation that is observable in tissue-scale mechanical parameters. Multi-scale mechanical testing was conducted to investigate the damage mechanisms by simultaneously quantifying tissue-scale mechanical and microstructural changes. The hierarchical structures of these tendons were studied using multiple imaging methods including histology, scanning electron microscopy (SEM), and confocal microscopy. ☐ At the tissue-scale, the transition strain, linear region modulus, and inflection point strain demonstrated strain-dependent changes in rat tail and plantaris tendons, suggesting that these metrics can be used to quantify the effect of damage. At the micro-scale, the micro-scale strain fully recovered following loading and unloading, yet the micro-scale sliding was only partially recoverable in all tendons. The non-recoverable sliding was strain-dependent in the tail and plantaris tendons, and the percentage of non-recoverable sliding was surprisingly similar between the tail and plantaris tendons. The non-recoverable sliding was related to the altered tissue-scale transition strain in the tail and plantaris tendons. Collectively, the micro-scale sliding is responsible for both loading and damage mechanisms for both non-load and load-bearing tendons. Achilles tendon demonstrated some of the mechanical responses observed in plantaris and tail tendons, yet the results were inconclusive due to its complex structure. Studying the hierarchical structure of these tendons demonstrated that fascicles are absent in rat tendons, and thus the fiber is the largest tendon subunit in rats, with the exception of rat tail tendon. We provided a structurally-based definition of fiber as a bundle of collagen fibrils that is surrounded by elongated cells, and the fiber diameters were consistently 10-50 μm, which is conserved across larger species. Understanding the mechanisms responsible for the pathogenesis and progression of tendinopathy can improve prevention and rehabilitation strategies and guide therapies and design of engineered constructs." @default.
- W2955145714 created "2019-07-12" @default.
- W2955145714 creator A5040938553 @default.
- W2955145714 date "2019-01-01" @default.
- W2955145714 modified "2023-09-27" @default.
- W2955145714 title "Tendon multi-scale structure, mechanical function, and damage" @default.
- W2955145714 cites W1004383157 @default.
- W2955145714 cites W1021610853 @default.
- W2955145714 cites W1481180598 @default.
- W2955145714 cites W1489982644 @default.
- W2955145714 cites W1504352848 @default.
- W2955145714 cites W1504756698 @default.
- W2955145714 cites W1512474466 @default.
- W2955145714 cites W1520586883 @default.
- W2955145714 cites W1558943498 @default.
- W2955145714 cites W1568247816 @default.
- W2955145714 cites W1605158933 @default.
- W2955145714 cites W162880682 @default.
- W2955145714 cites W1667085792 @default.
- W2955145714 cites W174750261 @default.
- W2955145714 cites W1858718475 @default.
- W2955145714 cites W18883367 @default.
- W2955145714 cites W1892427918 @default.
- W2955145714 cites W1900591660 @default.
- W2955145714 cites W1914541323 @default.
- W2955145714 cites W1928234825 @default.
- W2955145714 cites W1959781342 @default.
- W2955145714 cites W1963543877 @default.
- W2955145714 cites W1964253913 @default.
- W2955145714 cites W1965942838 @default.
- W2955145714 cites W1967304877 @default.
- W2955145714 cites W1969774185 @default.
- W2955145714 cites W1970499362 @default.
- W2955145714 cites W1975036994 @default.
- W2955145714 cites W1975541600 @default.
- W2955145714 cites W1977075267 @default.
- W2955145714 cites W1977820604 @default.
- W2955145714 cites W1980876292 @default.
- W2955145714 cites W1981011377 @default.
- W2955145714 cites W1981479750 @default.
- W2955145714 cites W1985133033 @default.
- W2955145714 cites W1985240333 @default.
- W2955145714 cites W1987867114 @default.
- W2955145714 cites W1988642695 @default.
- W2955145714 cites W1989066386 @default.
- W2955145714 cites W1990851605 @default.
- W2955145714 cites W1994682353 @default.
- W2955145714 cites W1994855047 @default.
- W2955145714 cites W1996075947 @default.
- W2955145714 cites W1996259670 @default.
- W2955145714 cites W1996493054 @default.
- W2955145714 cites W1996841581 @default.
- W2955145714 cites W1999028818 @default.
- W2955145714 cites W2000020862 @default.
- W2955145714 cites W2000147381 @default.
- W2955145714 cites W2001089996 @default.
- W2955145714 cites W2002412459 @default.
- W2955145714 cites W2008280378 @default.
- W2955145714 cites W2008844579 @default.
- W2955145714 cites W2011121403 @default.
- W2955145714 cites W2011575137 @default.
- W2955145714 cites W2014263075 @default.
- W2955145714 cites W2015846577 @default.
- W2955145714 cites W2016726612 @default.
- W2955145714 cites W2018041070 @default.
- W2955145714 cites W2018804148 @default.
- W2955145714 cites W2021175216 @default.
- W2955145714 cites W2023655454 @default.
- W2955145714 cites W2024118661 @default.
- W2955145714 cites W2024250498 @default.
- W2955145714 cites W2024804259 @default.
- W2955145714 cites W2025391298 @default.
- W2955145714 cites W2027019914 @default.
- W2955145714 cites W2027895936 @default.
- W2955145714 cites W2028462886 @default.
- W2955145714 cites W2031400733 @default.
- W2955145714 cites W2032040260 @default.
- W2955145714 cites W2032263402 @default.
- W2955145714 cites W2034564511 @default.
- W2955145714 cites W2035257309 @default.
- W2955145714 cites W2040526940 @default.
- W2955145714 cites W2040712419 @default.
- W2955145714 cites W2041859100 @default.
- W2955145714 cites W2047088755 @default.
- W2955145714 cites W2048325302 @default.
- W2955145714 cites W2048750629 @default.
- W2955145714 cites W2052480371 @default.
- W2955145714 cites W2054635074 @default.
- W2955145714 cites W2054705416 @default.
- W2955145714 cites W2057989196 @default.
- W2955145714 cites W2059035066 @default.
- W2955145714 cites W2059584457 @default.
- W2955145714 cites W2059934579 @default.
- W2955145714 cites W2063041370 @default.
- W2955145714 cites W2063627719 @default.
- W2955145714 cites W2064583176 @default.
- W2955145714 cites W2069197985 @default.
- W2955145714 cites W2073564287 @default.
- W2955145714 cites W2073605646 @default.
- W2955145714 cites W2079583888 @default.