Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955147095> ?p ?o ?g. }
- W2955147095 endingPage "1397" @default.
- W2955147095 startingPage "1389" @default.
- W2955147095 abstract "Tuberculosis ( TB ) is one of the most prevalent infections. However, anti‐ TB drugs induce adverse liver injury in up to 40% of patients. Studies on candidate genes have suggested that single‐nucleotide polymorphisms account for only a small contribution to the occurrence of anti‐TB drug‐induced liver injury ( ATLI ). In this study, whole‐genome DNA methylation analysis was performed to systematically screen the ATLI ‐associated factors in a 49 vs. 51 case‐control population. Next, 34 identified candidate probes were validated using Mass ARRAY in 296 cases and 288 controls. Our results indicated that 12 CpG sites on seven probes were positively associated with ATLI risk. Furthermore, we applied a CRISPR /Cas9‐mediated methylation modifiable cell model and demonstrated that four CpGs in or near the gene region of AK 2 , SLC 8A2 , and PSTPIP 2 affected the cellular response to rifampicin treatment. This study provides new biomarkers associated with ATLI occurrence." @default.
- W2955147095 created "2019-07-12" @default.
- W2955147095 creator A5012909927 @default.
- W2955147095 creator A5021144448 @default.
- W2955147095 creator A5030829801 @default.
- W2955147095 creator A5036755114 @default.
- W2955147095 creator A5042467158 @default.
- W2955147095 creator A5065681003 @default.
- W2955147095 creator A5070640043 @default.
- W2955147095 creator A5072211414 @default.
- W2955147095 creator A5074113584 @default.
- W2955147095 creator A5081946864 @default.
- W2955147095 creator A5084621584 @default.
- W2955147095 creator A5085629666 @default.
- W2955147095 creator A5085654086 @default.
- W2955147095 creator A5086522650 @default.
- W2955147095 creator A5091650806 @default.
- W2955147095 date "2019-08-06" @default.
- W2955147095 modified "2023-10-15" @default.
- W2955147095 title "Genome‐Wide Analysis of <scp>DNA</scp> Methylation and Antituberculosis Drug‐Induced Liver Injury in the Han Chinese Population" @default.
- W2955147095 cites W1816934998 @default.
- W2955147095 cites W1937837640 @default.
- W2955147095 cites W194745969 @default.
- W2955147095 cites W1972199218 @default.
- W2955147095 cites W1976214439 @default.
- W2955147095 cites W1979674827 @default.
- W2955147095 cites W1984561144 @default.
- W2955147095 cites W1992275101 @default.
- W2955147095 cites W2000151960 @default.
- W2955147095 cites W2002795755 @default.
- W2955147095 cites W2009165803 @default.
- W2955147095 cites W2013633540 @default.
- W2955147095 cites W2021767023 @default.
- W2955147095 cites W2025456566 @default.
- W2955147095 cites W2058293205 @default.
- W2955147095 cites W2061290402 @default.
- W2955147095 cites W2074425805 @default.
- W2955147095 cites W2082912595 @default.
- W2955147095 cites W2084250900 @default.
- W2955147095 cites W2090608172 @default.
- W2955147095 cites W2102692709 @default.
- W2955147095 cites W2131308455 @default.
- W2955147095 cites W2132464305 @default.
- W2955147095 cites W2142004616 @default.
- W2955147095 cites W2142618093 @default.
- W2955147095 cites W2154296286 @default.
- W2955147095 cites W2165311122 @default.
- W2955147095 cites W2315540614 @default.
- W2955147095 cites W2319097250 @default.
- W2955147095 cites W2342149796 @default.
- W2955147095 cites W2346829986 @default.
- W2955147095 cites W2351565907 @default.
- W2955147095 cites W2414305690 @default.
- W2955147095 cites W2473105536 @default.
- W2955147095 cites W2496726030 @default.
- W2955147095 cites W2530292798 @default.
- W2955147095 cites W2546877500 @default.
- W2955147095 cites W2551092411 @default.
- W2955147095 cites W2553009047 @default.
- W2955147095 cites W2582631391 @default.
- W2955147095 cites W2607843061 @default.
- W2955147095 cites W2615476883 @default.
- W2955147095 cites W2618549787 @default.
- W2955147095 cites W2626966859 @default.
- W2955147095 cites W2790605859 @default.
- W2955147095 cites W2884970709 @default.
- W2955147095 cites W2914963468 @default.
- W2955147095 doi "https://doi.org/10.1002/cpt.1563" @default.
- W2955147095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31247120" @default.
- W2955147095 hasPublicationYear "2019" @default.
- W2955147095 type Work @default.
- W2955147095 sameAs 2955147095 @default.
- W2955147095 citedByCount "16" @default.
- W2955147095 countsByYear W29551470952019 @default.
- W2955147095 countsByYear W29551470952020 @default.
- W2955147095 countsByYear W29551470952021 @default.
- W2955147095 countsByYear W29551470952022 @default.
- W2955147095 countsByYear W29551470952023 @default.
- W2955147095 crossrefType "journal-article" @default.
- W2955147095 hasAuthorship W2955147095A5012909927 @default.
- W2955147095 hasAuthorship W2955147095A5021144448 @default.
- W2955147095 hasAuthorship W2955147095A5030829801 @default.
- W2955147095 hasAuthorship W2955147095A5036755114 @default.
- W2955147095 hasAuthorship W2955147095A5042467158 @default.
- W2955147095 hasAuthorship W2955147095A5065681003 @default.
- W2955147095 hasAuthorship W2955147095A5070640043 @default.
- W2955147095 hasAuthorship W2955147095A5072211414 @default.
- W2955147095 hasAuthorship W2955147095A5074113584 @default.
- W2955147095 hasAuthorship W2955147095A5081946864 @default.
- W2955147095 hasAuthorship W2955147095A5084621584 @default.
- W2955147095 hasAuthorship W2955147095A5085629666 @default.
- W2955147095 hasAuthorship W2955147095A5085654086 @default.
- W2955147095 hasAuthorship W2955147095A5086522650 @default.
- W2955147095 hasAuthorship W2955147095A5091650806 @default.
- W2955147095 hasConcept C104317684 @default.
- W2955147095 hasConcept C135763542 @default.
- W2955147095 hasConcept C140173407 @default.
- W2955147095 hasConcept C141231307 @default.