Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955147504> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2955147504 endingPage "S389" @default.
- W2955147504 startingPage "S389" @default.
- W2955147504 abstract "Introduction: Ticagrelor has been shown to reduce microvascular injury compared to clopidogrel in ST-elevation myocardial infarction patients. However, comparable data is lacking in NSTE-ACS. Methods: From Mar 2018-Jan 2019, patients hospitalised for NSTE-ACS were prospectively randomised 1:1 to clopidogrel (300 mg loading then 75 mg daily) or ticagrelor (180 mg loading then 90 mg twice-daily). Coronary microvascular function was assessed with index of microcirculatory resistance (IMR) in the infarct related artery (IRA) and non-IRA before and after percutaneous coronary intervention (PCI) using a standard pressure-temperature coronary wire. Results: 40 patients were included (17 clopidogrel, 23 ticagrelor). Median age 53.5 (IQR 49.0–61.5) years, 35(87.5%) were male, 11(27.5%) had diabetes, 19(47.5%) were smokers. Median peak troponin T was 527 (175–1006.5)ng/L, median GRACE score 91.5 (78.3–103.3) and median SYNTAX score 13 (6–20). Baseline characteristics were similar between the 2 groups. There was no significant difference in the median baseline IMR between the 2 groups in both the IRA (clopidogrel 14.4 [IQR 12.2–18.6] vs ticagrelor 20.8 [11.3–27.4], p = 0.22) and non-IRA (14.0 [11.0–22.0] vs 14.0 [10.0–29.5] respectively, p = 0.74). 28 patients underwent PCI to the IRA (12 clopidogrel, 16 ticagrelor). There was no significant difference in the median post-PCI IMR between the 2 groups (19.5 [14.5–24.5] vs 29.0 [19.0–35.6] respectively, p = 0.11). However, there was significant worsening of post-PCI compared with pre-PCI IMR in the clopidogrel group (19.5 vs 15.0, p = 0.049) but not in the ticagrelor group (29.0 vs 25.4, p = 0.47). Conclusion: In our NSTE-ACS patients undergoing PCI, ticagrelor resulted in less disruption of coronary microvascular function compared to clopidogrel." @default.
- W2955147504 created "2019-07-12" @default.
- W2955147504 creator A5001719682 @default.
- W2955147504 creator A5009735463 @default.
- W2955147504 creator A5010987040 @default.
- W2955147504 creator A5017226541 @default.
- W2955147504 creator A5033184241 @default.
- W2955147504 creator A5047394155 @default.
- W2955147504 creator A5051744285 @default.
- W2955147504 creator A5058237579 @default.
- W2955147504 creator A5061956602 @default.
- W2955147504 creator A5071149493 @default.
- W2955147504 date "2019-01-01" @default.
- W2955147504 modified "2023-09-27" @default.
- W2955147504 title "Clopidogrel Versus Ticagrelor on Coronary Microvascular Function After Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS): A Randomised Trial" @default.
- W2955147504 doi "https://doi.org/10.1016/j.hlc.2019.06.594" @default.
- W2955147504 hasPublicationYear "2019" @default.
- W2955147504 type Work @default.
- W2955147504 sameAs 2955147504 @default.
- W2955147504 citedByCount "0" @default.
- W2955147504 crossrefType "journal-article" @default.
- W2955147504 hasAuthorship W2955147504A5001719682 @default.
- W2955147504 hasAuthorship W2955147504A5009735463 @default.
- W2955147504 hasAuthorship W2955147504A5010987040 @default.
- W2955147504 hasAuthorship W2955147504A5017226541 @default.
- W2955147504 hasAuthorship W2955147504A5033184241 @default.
- W2955147504 hasAuthorship W2955147504A5047394155 @default.
- W2955147504 hasAuthorship W2955147504A5051744285 @default.
- W2955147504 hasAuthorship W2955147504A5058237579 @default.
- W2955147504 hasAuthorship W2955147504A5061956602 @default.
- W2955147504 hasAuthorship W2955147504A5071149493 @default.
- W2955147504 hasBestOaLocation W29551475041 @default.
- W2955147504 hasConcept C126322002 @default.
- W2955147504 hasConcept C164705383 @default.
- W2955147504 hasConcept C2777698277 @default.
- W2955147504 hasConcept C2777849778 @default.
- W2955147504 hasConcept C2780400711 @default.
- W2955147504 hasConcept C2780890252 @default.
- W2955147504 hasConcept C45393284 @default.
- W2955147504 hasConcept C500558357 @default.
- W2955147504 hasConcept C71924100 @default.
- W2955147504 hasConceptScore W2955147504C126322002 @default.
- W2955147504 hasConceptScore W2955147504C164705383 @default.
- W2955147504 hasConceptScore W2955147504C2777698277 @default.
- W2955147504 hasConceptScore W2955147504C2777849778 @default.
- W2955147504 hasConceptScore W2955147504C2780400711 @default.
- W2955147504 hasConceptScore W2955147504C2780890252 @default.
- W2955147504 hasConceptScore W2955147504C45393284 @default.
- W2955147504 hasConceptScore W2955147504C500558357 @default.
- W2955147504 hasConceptScore W2955147504C71924100 @default.
- W2955147504 hasLocation W29551475041 @default.
- W2955147504 hasOpenAccess W2955147504 @default.
- W2955147504 hasPrimaryLocation W29551475041 @default.
- W2955147504 hasRelatedWork W2790813266 @default.
- W2955147504 hasRelatedWork W3032495098 @default.
- W2955147504 hasRelatedWork W3039138000 @default.
- W2955147504 hasRelatedWork W3110571006 @default.
- W2955147504 hasRelatedWork W3134665543 @default.
- W2955147504 hasRelatedWork W3135788989 @default.
- W2955147504 hasRelatedWork W3203361566 @default.
- W2955147504 hasRelatedWork W4205730351 @default.
- W2955147504 hasRelatedWork W4224250870 @default.
- W2955147504 hasRelatedWork W4288064445 @default.
- W2955147504 hasVolume "28" @default.
- W2955147504 isParatext "false" @default.
- W2955147504 isRetracted "false" @default.
- W2955147504 magId "2955147504" @default.
- W2955147504 workType "article" @default.