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• W2955149575 abstract "Peroxisome proliferator-activated receptor alpha (PPAR- α ) belongs to the PPAR family and plays a critical role in inhibiting cell proliferation and tumorigenesis in various tumors. However, the role of PPAR- α in colorectal tumorigenesis is unclear. In the present study, we found that fenofibrate, a PPAR- α agonist, significantly inhibited cell proliferation and induced apoptosis in colorectal carcinoma cells. In addition, PPAR- α was expressed in the nucleus of colorectal carcinoma cells, and the expression of nuclear PPAR- α increased in colorectal carcinoma tissue compared with that of normal epithelium tissue (P<0.01). The correlation between the expression of nuclear PPAR-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi mathvariant=normal>α</mml:mi></mml:mrow></mml:math>and clinicopathological factors was evaluated in human colorectal carcinoma tissues, and the nuclear expression of PPAR- α was significantly higher in well-to-moderately differentiated adenocarcinoma than in mucinous adenocarcinoma (P<0.05). These findings indicate that activation of PPAR- α may be involved in anticancer effects in colorectal carcinomas, and nuclear expression of PPAR- α may be a therapeutic target for colorectal adenocarcinoma treatment." @default.
• W2955149575 created "2019-07-12" @default.
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• W2955149575 date "2019-07-03" @default.
• W2955149575 modified "2023-10-18" @default.
• W2955149575 title "Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma" @default.
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• W2955149575 doi "https://doi.org/10.1155/2019/7486727" @default.
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