Matches in SemOpenAlex for { <https://semopenalex.org/work/W2955166257> ?p ?o ?g. }
- W2955166257 endingPage "499" @default.
- W2955166257 startingPage "487" @default.
- W2955166257 abstract "Although the complex roles of macrophages in myocardial injury are widely appreciated, the function of neutrophils in nonischemic cardiac pathology has received relatively little attention.To examine the regulation and function of neutrophils in pressure overload-induced cardiac hypertrophy, mice underwent treatment with Ly6G antibody to deplete neutrophils and then were subjected to transverse aortic constriction.Neutrophil depletion diminished transverse aortic constriction-induced hypertrophy and inflammation and preserved cardiac function. Myeloid deficiency of Wnt5a, a noncanonical Wnt, suppressed neutrophil infiltration to the hearts of transverse aortic constriction-treated mice and produced a phenotype that was similar to the neutropenic conditions. Conversely, mice overexpressing Wnt5a in myeloid cells displayed greater hypertrophic growth, inflammation, and cardiac dysfunction. Neutrophil depletion reversed the Wnt5a overexpression-induced cardiac pathology and eliminated differences in cardiac parameters between wild-type and myeloid-specific Wnt5a transgenic mice.These findings reveal that Wnt5a-regulated neutrophil infiltration has a critical role in pressure overload-induced heart failure." @default.
- W2955166257 created "2019-07-12" @default.
- W2955166257 creator A5010504937 @default.
- W2955166257 creator A5028625157 @default.
- W2955166257 creator A5030371908 @default.
- W2955166257 creator A5030601047 @default.
- W2955166257 creator A5034311334 @default.
- W2955166257 creator A5056214696 @default.
- W2955166257 creator A5060967318 @default.
- W2955166257 creator A5078623365 @default.
- W2955166257 creator A5081105112 @default.
- W2955166257 creator A5086658590 @default.
- W2955166257 creator A5090019639 @default.
- W2955166257 creator A5090809252 @default.
- W2955166257 date "2019-08-06" @default.
- W2955166257 modified "2023-10-16" @default.
- W2955166257 title "Wnt5a-Mediated Neutrophil Recruitment Has an Obligatory Role in Pressure Overload–Induced Cardiac Dysfunction" @default.
- W2955166257 cites W1532126421 @default.
- W2955166257 cites W1925096404 @default.
- W2955166257 cites W1965575731 @default.
- W2955166257 cites W1979475230 @default.
- W2955166257 cites W1981044204 @default.
- W2955166257 cites W1987980227 @default.
- W2955166257 cites W1999210891 @default.
- W2955166257 cites W2003870922 @default.
- W2955166257 cites W2010484682 @default.
- W2955166257 cites W2011513090 @default.
- W2955166257 cites W2011813460 @default.
- W2955166257 cites W2018204780 @default.
- W2955166257 cites W2018347789 @default.
- W2955166257 cites W2018822308 @default.
- W2955166257 cites W2026335686 @default.
- W2955166257 cites W2041370293 @default.
- W2955166257 cites W2050744280 @default.
- W2955166257 cites W2087959682 @default.
- W2955166257 cites W2088893424 @default.
- W2955166257 cites W2100847015 @default.
- W2955166257 cites W2106557745 @default.
- W2955166257 cites W2119610102 @default.
- W2955166257 cites W2135287165 @default.
- W2955166257 cites W2139465513 @default.
- W2955166257 cites W2141211759 @default.
- W2955166257 cites W2163809288 @default.
- W2955166257 cites W2164012871 @default.
- W2955166257 cites W2165379056 @default.
- W2955166257 cites W2272713913 @default.
- W2955166257 cites W2280206972 @default.
- W2955166257 cites W2292493149 @default.
- W2955166257 cites W2411824278 @default.
- W2955166257 cites W2479827938 @default.
- W2955166257 cites W2522665294 @default.
- W2955166257 cites W2543016513 @default.
- W2955166257 cites W2562661149 @default.
- W2955166257 cites W2597615908 @default.
- W2955166257 cites W2606461028 @default.
- W2955166257 cites W2624251034 @default.
- W2955166257 cites W2736390263 @default.
- W2955166257 cites W2739932646 @default.
- W2955166257 cites W2771388910 @default.
- W2955166257 cites W2772869455 @default.
- W2955166257 cites W2783025516 @default.
- W2955166257 cites W2791059232 @default.
- W2955166257 cites W2791529560 @default.
- W2955166257 cites W2792454313 @default.
- W2955166257 cites W2805322110 @default.
- W2955166257 cites W2889297987 @default.
- W2955166257 cites W4321429427 @default.
- W2955166257 doi "https://doi.org/10.1161/circulationaha.118.038820" @default.
- W2955166257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6684855" @default.
- W2955166257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31170826" @default.
- W2955166257 hasPublicationYear "2019" @default.
- W2955166257 type Work @default.
- W2955166257 sameAs 2955166257 @default.
- W2955166257 citedByCount "50" @default.
- W2955166257 countsByYear W29551662572018 @default.
- W2955166257 countsByYear W29551662572019 @default.
- W2955166257 countsByYear W29551662572020 @default.
- W2955166257 countsByYear W29551662572021 @default.
- W2955166257 countsByYear W29551662572022 @default.
- W2955166257 countsByYear W29551662572023 @default.
- W2955166257 crossrefType "journal-article" @default.
- W2955166257 hasAuthorship W2955166257A5010504937 @default.
- W2955166257 hasAuthorship W2955166257A5028625157 @default.
- W2955166257 hasAuthorship W2955166257A5030371908 @default.
- W2955166257 hasAuthorship W2955166257A5030601047 @default.
- W2955166257 hasAuthorship W2955166257A5034311334 @default.
- W2955166257 hasAuthorship W2955166257A5056214696 @default.
- W2955166257 hasAuthorship W2955166257A5060967318 @default.
- W2955166257 hasAuthorship W2955166257A5078623365 @default.
- W2955166257 hasAuthorship W2955166257A5081105112 @default.
- W2955166257 hasAuthorship W2955166257A5086658590 @default.
- W2955166257 hasAuthorship W2955166257A5090019639 @default.
- W2955166257 hasAuthorship W2955166257A5090809252 @default.
- W2955166257 hasBestOaLocation W29551662571 @default.
- W2955166257 hasConcept C111566952 @default.
- W2955166257 hasConcept C121332964 @default.
- W2955166257 hasConcept C126322002 @default.
- W2955166257 hasConcept C134018914 @default.